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Neuropsychology Review

, Volume 3, Issue 2, pp 119–169 | Cite as

Memory deficits in Alzheimer's patients: A comprehensive review

  • Giovanni A. Carlesimo
  • Marlene Oscar-Berman
Article

Abstract

Despite considerable experimental work on Alzheimer's disease (AD), the underlying cognitive mechanisms as well as the precise localization of neuropathological changes critical for memory loss remains undefined. A review of the neuropsychological literature on long-term memory deficits in AD patients suggests that AD patients display (a) a pervasive deficit of explicit memory, (b) a partial deficiency of implicit memory for verbal and visuoperceptual material (as measured by repetition priming procedures), and (c) a substantial sparing of implicit memory for visuomotor skills. The explicit memory loss is likely a result of encoding as well as consolidation difficulties. A faulty lexical-semantic knowledge structure appears responsible for deficient repetition priming effects. Since neuropathological changes diffusely affect the brain of AD patients, establishing a clear relationship between localization of cerebral lesions and memory deficits is particularly difficult. Nevertheless, data suggest that extensive involvement of the hippocampal-amygdala complex plays a major role in explicit memory loss. Damage to associative cortical areas likely is involved in repetition priming deficits. The relative integrity of primary motor and sensory cortical areas and of the basal ganglia likely subsume, by contrast, the normal learning of visuomotor skills.

Key words

Alzheimer memory cognition amnesia 

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References

  1. Albert, M. S., Butters, N., and Brandt, J. (1981). Patterns of remote memory in amnesic and demented patients.Archives of Neurology 38: 495–500.PubMedGoogle Scholar
  2. Albert, M. S., Butters, N., and Levin, J. (1979). Temporal gradients in the retrograde amnesia of patients with alcoholic Korsakoff's disease.Archives of Neurology 36: 211.PubMedGoogle Scholar
  3. Albert, M. S., Butters, N., and Levin, J. (1980). Memory for remote events in chronic alcoholics and alcoholic Korsakoff patients. In Begleiter, H. (ed.),Biological Effects of Alcohol, Plenum Press, New York, pp. 719–730.Google Scholar
  4. Amaral, D. G. (1987). Memory: Anatomical organization of candidate brain regions. In Plum, F. (ed.),The Handbook of Physiology, the Nervous System, V, Williams and Wilkins, Baltimore, MD, pp. 211–294.Google Scholar
  5. American Psychiatric Association (1980).Diagnostic and Statistical Manual of Mental Disorders (3rd ed.), Washington, DC.Google Scholar
  6. Arendt, T., Bigl, V., Arendt, A., and Tennstedt, A. (1983). Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's disease.Acta Neuropathologica 61: 101–108.PubMedGoogle Scholar
  7. Atkinson, R. C., and Shiffrin, R. M. (1968). Human memory: A proposed system and its control processes. In Spence, K.W., and Spence, J. T. (eds.),The Psychology of Learning and Motivation: Advances in Research and Theory, Vol. 2, Academic Press, New York, pp. 89–195.Google Scholar
  8. Atkinson, R. C., and Shiffrin, R. M. (1971). The control of short-term memory.Scientific American 225: 82–90.PubMedGoogle Scholar
  9. Backman, L., and Herlitz, A. (1990). The relationship between prior knowledge and face recognition memory in normal aging and Alzheimer's disease.Journal of Gerontology 45: P94-P100.PubMedGoogle Scholar
  10. Baddeley, A. D. (1976).Psychology of Memory, Basic Books, New York.Google Scholar
  11. Baddeley, A. D. (1982). Amnesia: A minimal model and an interpretation. In Cermak, L. S. (ed.),Human Memory and Amnesia, Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 305–336.Google Scholar
  12. Baddeley, A. D. (1986).Working Memory, Oxford University Press, London.Google Scholar
  13. Baddeley, A. D., and Hitch, G. (1974). Working memory. In Bower, G. H. (ed.),The Psychology of Learning and Motivation (Vol. 8), Academic Press, New York, pp. 47–90.Google Scholar
  14. Baddeley, A. D., and Scott, D. (1971). Short-term forgetting in the absence of proactive inhibition.Quarterly Journal of Experimental Psychology 23: 275–283.Google Scholar
  15. Baddeley, A. D., and Warrington, E. K. (1970). Amnesia and the distinction between long-and short-term memory.Journal of Verbal Learning and Verbal Behavior 9: 176–189.Google Scholar
  16. Baddeley, A., Logie, R., Bressi, S., Della Sala S., and Spinnler, H. (1986). Dementia and working memory.The Quarterly Journal of Experimental Psychology 38A; 603–618.Google Scholar
  17. Baso, A., Spinnler, H., Vallar, G., and Zanobio, M. E. (1982). Left hemisphere damage and selective impairment of auditory verbal short-term memory. A case study.Neuropsychologia 20: 263–274.PubMedGoogle Scholar
  18. Bayles, K. A., and Tomoeda, C. K. (1983). Confrontation naming in dementia.Brain and Language 19: 98–114.PubMedGoogle Scholar
  19. Beatty, W. W., Salmon, D. P., Butters, N., Heindel, W. C., and Granholm, E. L. (1988). Retrograde amnesia in patients with Alzheimer's disease or Huntington's disease.Neurobiology of Aging 9: 181–186.PubMedGoogle Scholar
  20. Becker, J. T., Boller, F., Saxton, J., and McGonigle-Gibson, K. (1987). Normal rates of forgetting of verbal and non-verbal material in Alzheimer's disease.Cortex 25: 59–72.Google Scholar
  21. Branconnier, R. J., Cole, J. O., Spera, K. F., and Devitt, D. R. (1982). Recall and recognition as diagnostic indices of malignant memory loss in senile dementia: A bayesian analysis.Experimental Ageing Research 8: 189–193.Google Scholar
  22. Brandt, J., Folstein, S. E., and Folstein, M. F. (1988). Differential cognitive impairment in Alzheimer's disease and Huntington's disease.Annals of Neurology 23: 555–561.PubMedGoogle Scholar
  23. Brandt, J., Spencer, M., McSorley, P., and Folstein, M. F. (1988). Semantic activation and implicit memory in Alzheimer disease.Alzheimer Disease and Associated Disorders 2: 112–119.PubMedGoogle Scholar
  24. Brion, S., and Mikol, J. (1978). Atteinte du noyau lateral dorsal du thalamus et syndrome de Korsakoff alcoolique.Journal of Neurological Science 38: 249–261.Google Scholar
  25. Brown, J. (1958). Some tests of the decay theory of immediate memory.Quarterly Journal of Experimental Psychology 10: 12–21.Google Scholar
  26. Brun, A., and Englund, E. (1981). Regional pattern of degeneration in Alzheimer's disease: Neuronal loss and histopathological grading.Histopathology 5: 9–564.Google Scholar
  27. Butters, N., and Miliotis, P. (1985). Amnesic disorders. In Heilman K. M., and Valenstein, E. (eds.),Clinical Neuropsychology, Oxford University Press, New York, Oxford, pp. 403–452.Google Scholar
  28. Butters, N., and Stuss, D. T. (1989). Diencephalic amnesia. In Boller, E. F., and Grafman, J. (eds.),Handbook of Neuropsychology, Vol. 3, Elsevier Science Publishers, New York, pp. 107–148.Google Scholar
  29. Butters, N., Albert, M. S., Sax, D. S., Miliotis, P., Nagode, J., and Sterste, A. (1983). The effect of verbal elaborators on the pictorial memory of brain-damaged patients.Neuropsychologia 21: 307–323.PubMedGoogle Scholar
  30. Cermak, L. S. (1972).Human Memory: Research and Theory, Ronald Press, New York.Google Scholar
  31. Cermak, L. S. (1982). The long and short of it in amnesia. In Cermak, L. S. (ed.),Human Memory and Amnesia, Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 43–60.Google Scholar
  32. Cermak, L. S., Talbot, N., Chandler, K., and Wolbarst, L. R. (1985). The perceptual priming phenomenon in amnesia.Neuropsychologia 23: 615–622.PubMedGoogle Scholar
  33. Cohen, N. J., and Corkin, S. (1981). The amnesic patient H. M.: Learning and retention of a cognitive skill.Society for Neuroscience Abstracts 7: 571.Google Scholar
  34. Cohen, N. J., and Squire, L. R. (1980). Preserved learning and retention of pattern-analyzing skill in amnesia: Dissociation of knowing how and knowing that.Science 210: 207–210.PubMedGoogle Scholar
  35. Cohen, N. J., and Squire, L. R. (1981). Retrograde amnesia and remote memory impairment.Neuropsychologia 19: 337–356.PubMedGoogle Scholar
  36. Cohen, R. L. (1981). On the generality of some memory laws.Scandinavian Journal of Psychology 22: 267–281.Google Scholar
  37. Corkin, S. (1968). Acquisition of motor skill after bilateral medical temporal-lobe excision.Neuropsychologia 6: 255–265.Google Scholar
  38. Corkin, S. (1982). Some relationship between global amnesias and the memory impairments in Alzheimer's disease. In Corkin, S., Davis, K. L., Growdon, J. H., Usdin, E., Wurtman, R. J. (eds.),Alzheimer's Disease: A Report of Progress. Aging (Vol. 19), Raven Press, New York, pp. 149–164.Google Scholar
  39. Corkin, S., Cohen, N. J., and Sagar, H. J. (1983). Memory for remote personal and public events after bilateral medial temporal lobectomy.Society for Neuroscience Abstracts 9: 28.Google Scholar
  40. Corkin, S., Growdon, J., Nissen, M. J., Huff, F. J., Freed, D. M., and Sagar, H. J. (1984). Recent advances in the neuropsychological study of Alzheimer's disease. In Wurtman, R. J., Corkin, S., and Growdon, J. (Eds.),Alzheimer's Disease: Advances in Basic Research and Therapies. Proceedings of the Third Meeting of the International Study Group on the Treatment of Memory Disorders Associated with Aging, Center for Brain Sciences and Metabolism Trust, Cambridge, MA, pp. 75–94.Google Scholar
  41. Craik, F. I. M. (1970). The fate of primary memory items in free recall.Journal of Verbal Learning and Verbal Behavior. 9: 143–148.Google Scholar
  42. Craik, F. I. M., and Lockhart, R. S. (1972). Levels of processing: A framework for memory research.Journal of Verbal Learning and Verbal Behavior 11: 671–684.Google Scholar
  43. Craik, F. I. M., and Tulving, E. (1975). Depth of processing and the retention of words in episodic memory.Journal of Experimental Psychology: General 104: 268–294.Google Scholar
  44. Cushman, L. A., Como, P. G., Booth, H., and Caine, E. D. (1988). Cued recall and release from proactive interference in Alzheimer's disease.Journal of Clinical and Experimental Neuropsychology 10: 685–692.PubMedGoogle Scholar
  45. Dale, H. C. A. (1967). Familiarity and free recall.Quarterly Journal of Experimental Psychology 19: 103–108.PubMedGoogle Scholar
  46. Dall'Ora, P., Della Sala, S., and Spinnler, H. (1989). Autobiographical memory, its impairment in amnesic syndromes.Cortex 25: 197–217.PubMedGoogle Scholar
  47. Damasio, A. R., Graff-Radford, N. R., Eslinger, P. J., Damasio, H., and Kassel, N. (1985). Amnesia following basal forebrain lesions.Archives of Neurology 42: 263–271.PubMedGoogle Scholar
  48. Davies, P., Katzman, R., and Terry, R. D. (1980). Reduced somatostatine-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementia.Nature 288: 279–290.PubMedGoogle Scholar
  49. Davis, P. E., and Mumford, S. J. (1984). Cued recall and nature of the memory disorder in dementia.The British Journal of Psychiatry 144: 383–386.PubMedGoogle Scholar
  50. Deese, J. (1959). Influence of inter item associative strength upon immediate free recall.Psychological Reports 5: 305–312.Google Scholar
  51. Delis, D. C., Massman, P. J., Butters, N., Salmon, D. P., Cermak, L. S., and Kramer, J. H. (1991). Profiles of demented and amnesic patients on the California Verbal Learning Test: Implications for the assessment of memory disorders.Psychological Assessment 3: 19–26.Google Scholar
  52. Dick, M. B., Kean, M. L., and Sands, D. (1989a). Memory for internally generated words in Alzheimer-type dementia: Breakdown in encoding and semantic memory.Brain and Cognition 9: 88–108.PubMedGoogle Scholar
  53. Dick, M. B., Kean, M. L., and Sands, D. (1989b). Memory for action events in Alzheimer-type dementia: Further evidence of an encoding failure.Brain and Cognition 9: 71–87.PubMedGoogle Scholar
  54. Diesfeldt, H. F. A. (1984). The importance of encoding instructions and retrieval cues in the assessment of memory in senile dementia.Archives of Gerontology and Geriatrics 3: 51–57.PubMedGoogle Scholar
  55. Eslinger, P. J., and Damasio, A. R. (1986). Preserved motor learning in Alzheimer's disease: Implications for anatomy and behavior.The Journal of Neuroscience 6: 3006–3009.PubMedGoogle Scholar
  56. Freed, D. M., Corkin, S., and Cohen, N. J. (1987). Forgetting in H.M.: A second look.Neuropsychologia 25: 461–471.PubMedGoogle Scholar
  57. Fuld, P. A., Katzman, R., Davies, P., and Terry, R. D. (1982). Intrusions as a sign of Alzheimer dementia: Chemical and pathological verification.Annals of Neurology 11: 155–159.PubMedGoogle Scholar
  58. Gabrieli, J. D. E. (1986).Memory subsystems of the human brain: Dissociations among learning capacities in amnesia. Unpublished doctoral dissertation, Massachusetts Institute of Technology, Cambridge, MA.Google Scholar
  59. Gabrieli, J. D. E. (1991). Differential effects of aging and age-related neurological diseases on memory subsystems of the brain. In Boller, F., and Grafman, J., (eds.),The Handbook of Neuropsychology Elsevier/North Holland, Amsterdam.Google Scholar
  60. Gabrieli, J. D. E., Keane, M. M., Stanger, B. Z., Kjelgaard, M. M., Growdon, J. H., and Corkin, S. (1992). Dissociations among structural-perceptual, lexical-semantic, and eventfact memory systems in amnesic, Alzheimer's, and normal subjects.Manuscript submitted for publication.Google Scholar
  61. Gibson, A. J. (1981). A further analysis of memory loss in dementia and depression in the elderly.British Journal of Clinical Psychology 20: 179–185.PubMedGoogle Scholar
  62. Glanzer, M., and Cunitz, A. R. (1966). Two storage mechanisms in free recall.Journal of Verbal Learning and Verbal Behavior 5: 351–360.Google Scholar
  63. Gollin, E. S. (1960). Developmental studies of visual recognition of incomplete objects.Perceptual and Motor Skills 11: 289–298.Google Scholar
  64. Graf, P., Shimamura, A. P., and Squire, L. R. (1985). Priming across modalities and priming across category levels: Extending the domain of preserved function in amnesia.Journal of Experimental Psychology: Learning, Memory, and Cognition 11: 386–396.Google Scholar
  65. Graf, P., Squire, L. R., and Mandler, G. (1984). The information that amnesic patients do not forget.Journal of Experimental Psychology: Learning, Memory and Cognition 10(1): 164–178.Google Scholar
  66. Granholm, E., and Butters, N. (1988). Associative encoding and retrieval and Alzheimer's and Huntington's disease.Brain and Cognition 7: 335–347.PubMedGoogle Scholar
  67. Grober, E., and Buschke, H. (1987). Genuine memory deficits in dementia.Developmental Neuropsychology 3: 13–36.Google Scholar
  68. Grosse, D. A., Wilson, R. S., and Fox, J. H. (1990). Preserved word-stem-completion priming of semantically encoded information in Alzheimer's disease.Psychology and Aging 5: 304–306.PubMedGoogle Scholar
  69. Grosse, D. A., Wilson, R. S., and Fox, J. H. (1991). Maze learning in Alzheimer's disease.Brain and Cognition 15: 1–9.PubMedGoogle Scholar
  70. Hardy, J., Adolfsson, R., Alafuzoff, I., Bucht, G., Marcusson, J., Nyberg, P., Perdahl, E., Wester, P., and Winblad, B. (1985). Transmitter deficit in Alzheimer's disease. A review.Neurochemistry International 7: 454–563.Google Scholar
  71. Hart, R. P., Kwentus, J. A., Taylor, J. R., and Harkins, S. W. (1987). Rate of forgetting in dementia and depression.Journal of Consultant and Clinical Psychology 55: 101–105.Google Scholar
  72. Hart, S., Smith, C. M., and Swash, M. (1986). Intrusion errors in Alzheimer's disease.British Journal of Clinical Psychology 25: 149–150.PubMedGoogle Scholar
  73. Heindel, W. C., Butters, N., and Salmon, D. P. (1988). Impaired learning of a motor skill in patients with Huntington's disease.Behavioral Neuroscience 102: 141–147.PubMedGoogle Scholar
  74. Heindel, W. C., Salmon, D. P., and Butters, N. (1990). Pictorial priming and cued recall in Alzheimer's and Huntington's disease.Brain and Cognition 13: 282–295.PubMedGoogle Scholar
  75. Heindel, W. C., Salmon, D. P., and Butters, N. (1991). The biasing of weight judgments in Alzheimer's and Huntington's disease: A priming or programming phenomenon?Journal of Clinical and Experimental Neuropsychology 13: 189–203.PubMedGoogle Scholar
  76. Heindel, W. C., Salmon, D. P., Shults, C. W., Walicke, P. A., and Butters, N. (1989). Neuropsychological evidence for multiple implicit memory systems: A comparison of Alzheimer's Huntington's, and Parkinson's disease patients.The Journal of Neuroscience 9: 582–587.PubMedGoogle Scholar
  77. Helkala, E. L., Laulumaa, V., Soininen, H., and Riekkinen, P. J. (1989). Different error pattern of episodic and semantic memory in Alzheimer's and Parkinson's disease with dementia.Neuropsychologia 27: 1241–1248.PubMedGoogle Scholar
  78. Herlitz, A., Adolfsson, R., Backman, L., and Nilsson, L. (1991). Cue utilization following different forms of encoding in mildly, moderately, and severely demented patients with Alzheimer's disease.Brain and Cognition 15: 119–130.PubMedGoogle Scholar
  79. Huff, F. J., Mack, L., Mahlmann, J., and Greenberg, S. (1988). A comparison of lexical-semantic impairments in left hemisphere stroke and Alzheimer's disease.Brain and Language 34: 262–278.PubMedGoogle Scholar
  80. Hultsch, D. F., and Dixon, R. A. (1983). The role of pre-experimental knowledge in test processing in adulthood.Experimental Aging Research 9: 17–22.PubMedGoogle Scholar
  81. Huppert, F. A., and Piercy, M. (1978). Dissociation between learning and remembering in organic amnesia.Nature 275: 317–318.PubMedGoogle Scholar
  82. Huppert, F. A., and Piercy, M. (1979). Normal and abnormal forgetting in amnesia: Effect of locus of lesion.Cortex 15: 385–390.PubMedGoogle Scholar
  83. Huppert, F. A., and Piercy, M. (1982). In search of the functional locus of amnesic syndromes. In Cermak, L. S. (ed.),Human Memory and Amnesia Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 123–138.Google Scholar
  84. Hyman, B. T., Kromer, L. J., and Van Hoesen, G. W. (1987). Reinnervation of the hippocampal perforant pathway zone in Alzheimer's disease.Annals of Neurology 21: 259–267.PubMedGoogle Scholar
  85. Hyman, B. T., Van Hoesen, G. W., and Damasio, A. R. (1990). Memory related neural systems in Alzheimer's disease: An anatomic study.Neurology 40: 1721–1730.PubMedGoogle Scholar
  86. Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., and Barnes, C. L. (1984). Alzheimer's disease: Cell specific pathology isolates the hippocampal formation.Science 225: 1168–1170.PubMedGoogle Scholar
  87. Hyman, B. T., Van Hoesen, G. W., Kromer, L. J., and Damasio, A. R. (1986). Perforant pathway changes and the memory impairment of Alzheimer's disease.Annals of Neurology 20: 472–481.PubMedGoogle Scholar
  88. Jacobs, D., Salmon, D. P. Troster, A. I., and Butters, N. (1990). Intrusion errors in the figural memory of patients with Alzheimer's and Huntington's disease.Archives of Clinical Neuropsychology 5: 49–57.PubMedGoogle Scholar
  89. Jacobs, D., Troster, A. I., Butters, N., Salmon, D. P., and Cermak, L. (1990). Intrusion errors on the visual reproduction test on the Wechsler Memory Scale and the Wechsler Memory Scale-Revised: An analysis of demented and amnesic patients.The Clinical Neuropsychologist 4: 177–191.Google Scholar
  90. Jacoby, L. L. (1982). Knowing and remembering: Some parallels in the behavior of Korsakoff patients and normals. In Cermak, L. S. (ed.)Human Memory and Amnesia Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 97–122.Google Scholar
  91. Jacoby, L. L. (1983). Remembering the data: Analyzing interactive processes in reading.Journal of Verbal Learning and Verbal Behavior 22: 485–508.Google Scholar
  92. Jacoby, L. L., and Brooks, L. R., (1984). Nonanalytic cognition: Memory, perception, and concept learning. In Bower, G. H. (ed.),The Psychology of Learning and Motivation (Vol. 18), Academic Press, New York, pp. 1–47.Google Scholar
  93. Jacoby, L. L., and Dallas, M. (1981). On the relationship between autobiographical memory and perceptual learning.Journal of Experimental Psychology: General 110: 306–340.Google Scholar
  94. Karlsson, T., Backman, L., Herlitz, A., Nilsson, L. G., Winblad, B., and Osterlind, P. O. (1989). Memory improvement at different stages of Alzheimer's disease.Neuropsychologia 27: 737–742.PubMedGoogle Scholar
  95. Kaszniak, A. W., and Garron, D. C. (1979). Differential aspects of age and cerebral atrophy upon span of immediate recall and paired associate learning in older patients with suspected dementia.Cortex 15: 285–295.PubMedGoogle Scholar
  96. Katzman, R. (1986). Alzheimer's disease.New England Journal of Medicine 314: 964–973.PubMedGoogle Scholar
  97. Katzman, R., and Karasu, T. B. (1975). Differential diagnosis of dementia. In Fields, W. S. (ed.),Neurological and Sensory Disorders in the Elderly, Stratton, pp. 103–134.Google Scholar
  98. Keane, M. M., Gabrieli, J. D. E., Fennema, A. C., Growdon, J. H., and Corkin, S. (1991). Evidence for a dissociation between perceptual and conceptual priming in Alzheimer's disease.Behavioral Neuroscience 105: 326–342.PubMedGoogle Scholar
  99. Keane, M. M., Gabrieli, J. D. E., Growdon, J. H., and Corkin, S. (1991). Patients with Alzheimer's disease show normal priming in perceptual identification of pseudowords.Society for Neuroscience Abstracts 17: 3.Google Scholar
  100. Keppel, G., and Underwood, B. J. (1962). Proactive inhibition in short-term retention of single items.Journal of Verbal Learning and Verbal Behavior. 1: 153–161.Google Scholar
  101. Kirsner, K., Milech, D., and Stander, P. (1983). Common and modality-specific processes in the mental lexicon.Memory and Cognition 11: 621–630.Google Scholar
  102. Knopman, D. D., and Nissen, M. J. (1987). Implicit learning in patients with probable Alzheimer's disease.Neurology 37: 784–788.PubMedGoogle Scholar
  103. Kopelman, M. D. (1985). Rates of forgetting in Alzheimer-type dementia and Korsakoff's syndrome.Neuropsychologia 23: 623–638.PubMedGoogle Scholar
  104. Kopelman, M. D. (1986). The cholinergic neurotransmitter system in human memory and dementia: A review.Quarterly Journal of Experimental Psychology 38A: 535–573.Google Scholar
  105. Kopelman, M. D. (1989). Remote and autobiographical memory, temporal context memory and frontal atrophy in Korsakoff and Alzheimer patients.Neuropsychologia 27: 437–460.PubMedGoogle Scholar
  106. Kopelman, M. D., and Corn, T. H. (1988). Cholinergic ‘blockade’ as a model for cholinergic depletion.Brain 111: 1079–1110.PubMedGoogle Scholar
  107. Maragos, W. F., Greenamyre, J. T., Penney, J. B., and Young, A. B. (1987). Glutamate dysfunction in Alzheimer's disease: An hypothesis.Trends in Neuroscience 10: 65–68.Google Scholar
  108. Martin, A., Browers, P., Cox, C., and Fedio, P. (1985). On the nature of the verbal memory deficit in Alzheimer's disease.Brain and Language 25: 323–341.PubMedGoogle Scholar
  109. Martone, M., Butters, N., Payne, M., Becker, J. T., and Sax, D. S. (1984). Dissociations between skill learning and verbal recognition in amnesia and dementia.Archives of Neurology 41: 965–970.PubMedGoogle Scholar
  110. McKhan, G., Drachman, D., Folstein, M., Katzman, R., Price, D., and Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease.Neurology 34: 939–944.PubMedGoogle Scholar
  111. Miller, E. (1971). On the nature of the memory disorder in presenile dementia.Neuropsychologia 9: 75–81.PubMedGoogle Scholar
  112. Miller, E. (1972). Efficiency of coding and short-term memory deficit in presenile dementia.Neuropsychologia 10: 221–224.Google Scholar
  113. Miller, E. (1973). Short- and long-term memory in patients with presenile dementia (Alzheimer's disease).Psychological Medicine 3: 221–224.PubMedGoogle Scholar
  114. Miller, E. (1975). Impaired recall and the memory disturbance in presenile dementia.British Journal of Social and Clinical Psychology 14: 73–79.PubMedGoogle Scholar
  115. Miller, E. (1977).Abnormal Ageing, Wiley, New York.Google Scholar
  116. Miller, E. (1978). Retrieval from long-term memory in presenile dementia: two tests of an hypothesis.British Journal of Social and Clinical Psychology 17: 143–148.PubMedGoogle Scholar
  117. Miller, E., and Lewis, P. (1977). Recognition memory in elderly patients with depression and dementia: A signal detection analysis.Journal of Abnormal Psychology 86: 84–86.PubMedGoogle Scholar
  118. Miller, G. A., and Selfridge, J. A. (1950). Verbal context and the free recall of meaningful material.American Journal of Psychology 63: 176–185.PubMedGoogle Scholar
  119. Mishkin, M. (1982). A memory system in the monkey.Philosophical Transactions of the Royal Society (London B) 298: 85–95.Google Scholar
  120. Mitchell, D. B., Hunt, R. S., and Schmitt, F. A. (1986). The generation effect and reality monitoring: Evidence from dementia and normal aging.Journal of Gerontology 4: 79–84.Google Scholar
  121. Morris, R. G. (1984). Dementia and the functioning of the articulatory loop system.Cognitive Neuropsychology 1: 143–157.Google Scholar
  122. Morris, R. G. (1986). Short-term forgetting in senile dementia of the Alzheimer's type.Cognitive Neuropsychology 3: 77–97.Google Scholar
  123. Morris, R. G. (1987a). Articulatory rehearsal in Alzheimer-type dementia.Brain and Language 30: 351–362.PubMedGoogle Scholar
  124. Morris, R. G. (1987b). The effect of concurrent articulation on memory span in Alzheimertype dementia.British Journal of Clinical Psychology 26: 233–234.PubMedGoogle Scholar
  125. Morris, R. G., Wheatley, J., and Britton, P. (1983). Retrieval from long-term memory in senile dementia: Cued recall revisited.British Journal of Clinical Psychiatry 22: 141–142.Google Scholar
  126. Moscovitch, M. (1982). A neuropsychological approach to perception and memory in normal and pathological aging. In Craik, F. I. M., and Trehub, S. (eds.),Aging and Cognitive Processes, Plenum Press, New York, pp. 55–79.Google Scholar
  127. Moss, M. B., Albert, M. S., Butters, N., and Payne, M. (1986). Differential patterns of memory loss among patients with Alzheimer's disease, Huntington's disease and alcoholic Korsakoff's syndrome.Archives of Neurology 43: 239–246.PubMedGoogle Scholar
  128. Murdock, B. B. (1967). Auditory and visual stores in short-term memory.Acta Psychologica 27: 316–324.PubMedGoogle Scholar
  129. Nebes, R. D. (1989). Semantic memory in Alzheimer's disease.Psychological Bulletin 106: 377–394.PubMedGoogle Scholar
  130. Nebes, R. D., Brady, C. B., and Huff, F. J. (1989). Automatic and attentional mechanisms of semantic priming in Alzheimer's disease.Journal of Clinical and Experimental Neuropsychology 11: 219–230.PubMedGoogle Scholar
  131. Nebes, R. D., Martin, D. C., and Horn, L. C. (1984). Sparing of semantic memory in Alzheimer's disease.Journal of Abnormal Psychology 93: 312–330.PubMedGoogle Scholar
  132. Ober, B. A., and Shenaut, G. K. (1988). Lexical decision and priming in Alzheimer's disease.Neuropsychologia 26: 273–286.PubMedGoogle Scholar
  133. Ober, B. A., Koss, E., Friedland, R. P., and Delis, D. C. (1985). Processes of verbal memory failure in Alzheimer-type dementia.Brain and Cognition 4: 90–103.PubMedGoogle Scholar
  134. Orsini, A., Trojano, L., Chiaccio, L., and Grossi, D. (1888). Immediate memory span in dementia.Perceptual and Motor Skills 67: 267–272.Google Scholar
  135. Oscar-Berman, M. (1973). Hypothesis testing and focusing behavior during concept formation by amnesic Korsakoff patients.Neuropsychologia 11: 191–198.PubMedGoogle Scholar
  136. Oscar-Berman, M. (1980). Neuropsychological consequences of long-term chronic alcoholism.American Scientist 68: 410–419.PubMedGoogle Scholar
  137. Oscar-Berman, M., McNamara, P., and Freedman, M. (1991). Delayed response tasks: Parallels between experimental ablation studies and findings in patients with frontal lesions. In Levin, H. S., Eisenberg, H. M., and Benton, A. L. (eds.),Frontal Lobe Function and Injury, Oxford University Press, New York.Google Scholar
  138. Paivio, A. (1969). Mental imagery in associative learning and memory.Psychological Review 76: 241–263.Google Scholar
  139. Paivio, A. (1971).Imagery and Verbal Processes, Holt, Rinehart & Winston, New York.Google Scholar
  140. Partridge, F. M., Knight, R. G., and Feehan, M. (1990). Direct nd indirect memory performance in patients with senile dementia.Psychological Medicine 20: 111–118.PubMedGoogle Scholar
  141. Pearson, R. C. A., Esiri, M. M., Hiorns, R. W., Wilcock, G. K., and Powell, T. P. S. (1985). Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease.Proceedings of the National Academy of Science USA 82: 4531–4534.Google Scholar
  142. Perry, E. K., and Perry R. H. (1986). A review of neuropathological and neurochemical correlates of the Alzheimer's disease.Danish Medical Bulletin 32, (suppl. 1): 27–34.Google Scholar
  143. Petersen, S. E., Fox, P. T. Snyder, A. Z., and Raichle, M. E. (1990). Activation of extrastriate and frontal cortical areas by visual words and word-like stimuli.Science 249: 1041–1044.PubMedGoogle Scholar
  144. Peterson, L. R., and Peterson, M. J. (1959). Short-term retention of individual verbal items.Journal of Experimental Psychology 58: 193–198.PubMedGoogle Scholar
  145. Richardson-Klavehn, A., and Bjork, R. A. (1988). Measures of memory.Annual Review of Psychology 39: 475–543.Google Scholar
  146. Rissenberg, M., and Glanzer, M. (1986). Picture superiority in free recall: The effect of normal aging and primary degenerative dementia.Journal of Gerontology 41: 64–71.PubMedGoogle Scholar
  147. Rissenberg, M., and Glanzer, M. (1987). Free recall and word finding ability in normal aging and senile dementia of the Alzheimer's type: the effect of item concreteness.Journal of Gerontology 42: 318–322.PubMedGoogle Scholar
  148. Roediger, H. L. (1990). Implicit memory. Retention without remembering.American Psychologist 45: 1043–1056.PubMedGoogle Scholar
  149. Roediger, H. L., Weldon, M. S., and Challis, B. H. (1989). Explaining dissociations between implicit and explicit measures of retention: A processing account. In Roediger, H. L., and Craik, F. I. M. (eds.),Varieties of Memory and Consciousness: Essays in Honour of Endel Tulving, Erlbaum, Hillsdale, NJ, pp. 3–41.Google Scholar
  150. Rossor, M. N., Iversen, L. L., Reynolds, G. P., Mountjoy, C. Q., and Roth, M. (1984). Neurochemical characteristics of early and late onset types of Alzheimer's disease.British Medical Journal 288: 961–964.PubMedGoogle Scholar
  151. Sagar, H. J., Cohen, N. J., Sullivan, E. V., Corkin, S., and Growdon, J. H. (1988). Remote memory function in Alzheimer's disease and Parkinson's disease.Brain 111: 525–539.PubMedGoogle Scholar
  152. Salmon, D. P., Granholm, E., McCullough, D., Butters, N., and Grant, I. (1989). Recognition memory span mildly and moderately demented patients with Alzheimer's disease.Journal of Clinical and Experimental Neuropsychology 11: 429–443.PubMedGoogle Scholar
  153. Salmon, D. P., Shimamura, A. P., Butters, N., and Smith, S. (1988). Lexical and semantic priming deficits in patients with Alzheimer's disease.Journal of Clinical and Experimental Neuropsychology 10: 477–494.PubMedGoogle Scholar
  154. Schacter, D. L. (1990). Perceptual representation systems and implicit memory: Toward a resolution of the multiple memory systems debate. In Diamond A. (ed.),Developmental and Neural Bases of Higher Cognitive Function, New York Academy of Sciences, New York, pp. 543–571.Google Scholar
  155. Schultz, K. A., Schmitt, F. A., Logue, P. E., and Rubin, D. C. (1986). Unit analysis of prose memory in clinical and elderly populations.Developmental Neuropsychology 2: 77–87.Google Scholar
  156. Scoville, W. B., and Milner, B. (1957). Loss of recent memory after bilateral hippocampal lesions.Journal of Neurology, Neurosurgery and Psychiatry 20: 11–21.Google Scholar
  157. Shallice, T., and Warrington, E. K. (1970). Independent functioning of verbal memory stores: A neuropsychological study.Quarterly Journal of Experimental Psychology 22: 261–273.PubMedGoogle Scholar
  158. Shiffrin, R. M. (1970). Forgetting: Trace erosion or retrieval failure?Science 168: 1601–1603.PubMedGoogle Scholar
  159. Shimamura, A. P. (1986). Priming effects in amnesia: Evidence for a dissociable memory function.The Quarterly Journal of Experimental Psychology 38A: 619–644.Google Scholar
  160. Shimamura, A. P. (1990). Forms of memory: Issues and directions. In McCaugh, J. L., Weinberger, N. M., and Lynch, G. (eds.),Brain Organization and Memory. Cells, Systems, and Circuits Oxford University Press, New York, Oxford, pp. 159–176.Google Scholar
  161. Shimamura, A. P., and Squire, L. R. (1984). Paired-associate learning and priming effects in amnesia: A neuropsychological study.Journal of Experimental Psychology: General 113: 556–570.Google Scholar
  162. Shimamura, A. P., and Squire, L. R. (1987). A neuropsychological study of fact memory and source amnesia.Journal of Experimental Psychology: Learning Memory and Cognition 13: 464–473.Google Scholar
  163. Shimamura, A. P., Salmon, D. P., Squire, L. R., and Butters, N. (1987). Memory dysfunction and word priming in dementia and amnesia.Behavioral Neuroscience 101: 347–351.PubMedGoogle Scholar
  164. Slamecka, N. J., and Graf, P. (1978). The generation effect: Delineation of a phenomenon.Journal of Experimental Psychology: Human Learning and Memory 4: 592–604.Google Scholar
  165. Spinnler, H., Della Sala, S., Bandera, R., and Baddeley, A. (1988). Dementia, aging, and the structure of human memory.Cognitive Neuropsychology 5: 193–211.Google Scholar
  166. Squire, L. R. (1981). Two forms of human amnesia: An analysis of forgetting.Journal of Neuroscience 1: 635–640.PubMedGoogle Scholar
  167. Squire, L. R. (1982). Comparison between forms of amnesia: Some deficits are unique to Korsakoff's syndrome.Journal of Experimental Psychology: Human Learning and Memory 8: 560–571.Google Scholar
  168. Squire, L. R. (1987).Memory and Brain, Oxford University Press, New York, Oxford.Google Scholar
  169. Squire, L. R., and Cohen, N. J. (1982). Remote memory, retrograde amnesia and the neuropsychology of memory. In Cermak, L. S. (ed.),Human Memory and Amnesia, Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 275–303.Google Scholar
  170. Strauss, M. E., Weingartner, H., and Thompson, K. (1985). Remembering words and how often they occurred in memory-impaired patients.Memory and Cognition 13: 507–510.Google Scholar
  171. Terry, R. D., Katzman, R. (1984). Senile dementia of the Alzheimer type.Annals of Neurology 14: 497–506.Google Scholar
  172. Thomson, D. M., and Tulving, E. (1970). Associative encoding and retrieval: weak and strong cues.Journal of Experimental Psychology 86: 255–262.Google Scholar
  173. Tomlinson, B. E., Blessed, G., and Roth, M. (1970). Observations on the brain of demented old people.Journal of Neurological Sciences 11: 205–242.Google Scholar
  174. Tulving, E. (1968). Theoretical issues in free recall. In Dixon, T. R., Horton, D. L. (eds.),Verbal Behavior and General Behavior Theory, Prentice-Hall, Englewood Cliffs, NJ.Google Scholar
  175. Tulvin, E. (1983).Elements of Episodic Memory, Oxford University Press, Oxford.Google Scholar
  176. Tulving, E. (1972). Episodic and semantic memory. In Tulving, E., Donaldson, W. (eds.),Organization of Memory, Academic Press, New York, pp. 381–403.Google Scholar
  177. Tulving, E., and Schacter, D. L. (1990). Priming and human memory systems.Science 247: 301–306.PubMedGoogle Scholar
  178. Vallar, G., and Baddeley, A. D. (1984). Fractionation of working memory: neuropsychological evidence for a phonological short-term store.Journal of Verbal Learning and Verbal Behavior 23: 151–161.Google Scholar
  179. Van Hoesen, G. W., and Damasio, A. R. (1987). Neural correlates of cognitive impairment in Alzheimer's disease. In Plum, F. (ed.),The Handbook of Physiology, The Nervous System, Vol. V, Williams and Wilkins, Baltimore, MD, pp. 871–898.Google Scholar
  180. Victor, M., Adams, R. D., and Collins, G. H. (1971).The Wernicke-Korsakoff Syndrome, Davis, Philadelphia, PA.Google Scholar
  181. Von Cramon, D. Y., Hebel, N., and Schuri, U. (1985). A contribution to the anatomical basis of thalamic amnesia.Brain 108: 993–1008.PubMedGoogle Scholar
  182. Wallin, A., Gottfries, C. G. (1990). Biochemical substrates in normal aging and Alzheimer's disease.Pharmacopsychiatry 23(Suppl. 2): 37–43.PubMedGoogle Scholar
  183. Warrington, E. K., and Weiskrantz, L. (1968). A new method of testing long-term retention with special reference to amnesic patients.Nature 217: 972–974.PubMedGoogle Scholar
  184. Warrington, E. K., and Weiskrantz, L. (1970). Amnesic syndrome: Consolidation or retrieval?Nature 228: 628–630.PubMedGoogle Scholar
  185. Weingartner, H., Kaye, W., Smallberg, S. A., Ebert, M. H., Gillan, J. C., and Sitaram, N. (1981). Memory failures in progressive idiopathic dementia.Journal of Abnormal Psychology 90: 187–196.PubMedGoogle Scholar
  186. Weingartner, H., Grafman, J., Boutelle, W., Kaye, W., and Martin, P. R. (1983). Forms of memory failure.Science 221: 380–382.PubMedGoogle Scholar
  187. Weiskrantz, L. (1982). Comparative aspects of studies in amnesia.Philosophical Transactions of the Royal Society (London) B 298: 97–109.Google Scholar
  188. Weiskrantz, L., and Warrington, E. K. (1979). Conditioning in amnesic patients.Neuropsychologia 17: 187–194.PubMedGoogle Scholar
  189. Welsh, K., Butters, N., Hughes, J., Mohs, R., and Heyman, A. (1991). Detection of abnormal memory decline in mild cases of Alzheimer's disease using CERAD neuropsychological measures.Archives of Neurology 48: 278–281.PubMedGoogle Scholar
  190. Whitehouse, P. J., Price, D. L., Struble, R. G., Clark, A. W., Coyle, J. T., and DeLong, M. R. (1982). Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain.Science 215: 1237–1239.PubMedGoogle Scholar
  191. Wilson, R. S., Kaszniak, A. W., and Fox, J. H. (1981). Remote memory in senile dementia.Cortex 17: 41–48.PubMedGoogle Scholar
  192. Wilson, R. S., Kaszniak, A. W., Bacon, L. D., and Fox, J. H. (1982). Facial recognition memory in dementia.Cortex 18: 329–336.PubMedGoogle Scholar
  193. Wilson, R. S., Bacon, L. D., Fox, J. H., and Kaszniak, A. W. (1983). Primary memory and secondary memory in dementia of the Alzheimer type.Journal of Clinical Neuropsychology 5: 337–344.PubMedGoogle Scholar
  194. Wilson, R. S., Bacon, L. D., Kramer, R. L., Fox, J. H., and Kaszniak, A. W. (1983). Word frequency effect and recognition memory in dementia of the Alzheimer type.Journal of Clinical Neuropsychology 5: 97–104.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • Giovanni A. Carlesimo
    • 1
  • Marlene Oscar-Berman
    • 2
    • 3
  1. 1.Istituto di NeurologiaII Università di RomaItaly
  2. 2.Psychology ServiceU.S. Department of Veterans Affairs Medical CenterBoston
  3. 3.Department of Neurology and Division of PsychiatryBoston University School of MedicineBoston

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