Neurosurgical Review

, Volume 20, Issue 4, pp 269–273 | Cite as

Sarcoidosis en-plaque. Report of a case and review of the literature

  • Erol Taşdemiroglu
  • Mohammed Nazek
  • Mario Zuccarello


A 31-year-old black male with sarcoidosis en-plaque of the dura mater, which is a rare morphological variant of neurosarcoidosis (NS), presented at our clinic. Magnetic resonance imaging (MRI) of the head with gadolinium showed non-specific enhancement of both tentorial leaves extending to the floor of right middle cranial fossa and cavernous sinus. The laboratory results were normal except for slightly increased serum angiotensin converting enzyme (SACE) (68 U/ml n = 4–56 U/ml) and cerebrospinal fluid (CSF) IgG index (0.57, n = 0.46). Biopsy of the intracranial dural lesion was consistent with sarcoidosis. Oral steroid therapy (Methylprednisolone 4 mg QID) was started and the patient became asymptomatic. However, MRI of the brain with gadolinium 2 months after biopsy showed progression and extension of the enhanced dural lesion. His SACE level was unchanged. We concluded that progression of the enhanced lesion seen in MRI could be recently formed scar tissue, new lesion or both. MRI findings should always be correlated with clinical findings for evaluation of NS during follow-up.


Dura mater magnetic resonance imaging neurosarcoidosis 


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Copyright information

© Walter de Gruyter & Co. 1997

Authors and Affiliations

  • Erol Taşdemiroglu
    • 1
    • 2
  • Mohammed Nazek
    • 1
  • Mario Zuccarello
    • 1
  1. 1.Veterans Affairs Medical CenterNeurosurgical ServicesCincinnatiUSA
  2. 2.Incirli CaddesiIstanbulTurkey

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