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Toxicological detection of ethylenediamine and piperazine antihistamines and their metabolites in urine by computerized gas chromatography-mass spectrometry

  • Hans Maurer
  • Karl Pfleger
Original Papers Chromatographic Methods

Summary

A gas chromatographic-mass spectrometric procedure for the detection of the following ethylenediamine and piperazine antihistamines and their metabolites in urine after acid hydrolysis, extraction and acetylation is described: Adeptolon, antazoline, bamipine, buclizine, chlorcyclizine, chloropyramine, cinnarizine, clemizole, cyclizine, etodroxizine, histapyrrodine, hydroxyzine, meclozine, mepyramine, oxatomide and tripelenamine. The acetylated extract was analysed by computerized gas chromatography-mass spectrometry. Using ion chromatography with the selective ions m/z 58, 72, 85, 125, 165, 183, 198 and 201 the possible presence of ethylenediamine or piperazine antihistamines or their metabolites was indicated. The identity of positive signals in the reconstructed ion chromatograms was then confirmed by a visual or computerized comparison of the stored full mass spectra with the reference spectra. The ion chromatograms, reference mass spectra and gas chromatographic retention indices (OV-101) are documented. The procedure presented is integrated in a general screening procedure (general unknown analysis) for several groups of drugs.

Keywords

Hydroxyzine Cinnarizine Mepyramine Oxatomide Cyclizine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Toxikologischer Nachweis von Ethylendiamin- und Piperazin-Antihistaminica und ihren Metaboliten im Urin mittels computerunterstützter Gas-Chromatographie-Massenspektrometrie

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Hans Maurer
    • 1
  • Karl Pfleger
    • 1
  1. 1.Institut für Pharmakologie und Toxikologie der Universität des SaarlandesHomburg/SaarGermany

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