Archives of Dermatological Research

, Volume 287, Issue 3–4, pp 289–293 | Cite as

Mechanical properties of keloids in vivo during treatment with intralesional triamcinolone acetonide

  • Thomas Krusche
  • Wolf-Ingo Worret
Original Paper


The mechanical properties of 17 keloids in 9 patients before and during treatment with intralesional triamcinolone acetonide were studied using a recently developed noninvasive suction device for measuring skin elasticity in vivo. Each keloid was treated with intralesional injections of 10 mg/ml triamcinolone acetonide without local anaesthetic at intervals of 3 weeks. A total of four measurements per keloid were performed, before treatment and 3 weeks after the first, second and third treatments. The parameters used were: immediate distension (Ue), delayed distension (Uv), immediate retraction (Ur) and final distension (Uf). Relative parameters independent of skin thickness were calculated:Uv/Ue, the ratio between the viscous and the elastic deformation of the skin, andUr/Uf, representing the ability of the skin to return to its initial position after deformation (biological elasticity). After three injections of triamcinolone acetonide a marked decrease inUv/Ue and a lesspronounced increase inUr/Uf compared with baseline values was observed. These findings indicate that the main effect of intralesional steroids on the connective tissue of keloids is a decrease in viscosity due to a loss of ground substance. This method provides a noninvasive quantitative assessment of the mechanical properties of scars and is well suited to comparative studies on the efficacy of various scar therapies.

Key words

Keloids Hypertrophic scars Skin elasticity Skin viscosity Intralesional steroids 


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Thomas Krusche
    • 1
  • Wolf-Ingo Worret
    • 1
  1. 1.Dermatologische Klinik und Poliklinik der Technischen Universität MünchenMünchenGermany

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