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Survey of mycotic and bacterial keratitis in Sri Lanka

Abstract

Over a two-year period (1976–1977 and 1980–1981), 66 cases of bacterial and mycotic cases of keratitis were diagnosed in the Eye Clinic of the General Hospital in Kandy, Sri Lanka. The clinical and microbiologic aspects of these cases are described. Noteworthy was the first known human case caused byPaecilomyces farinosus, a geophilic species, commonly encountered as an insect parasite throughout the world. The bacterial and the other fungal etiologic agents isolated and identified were:Pseudomonas aeruginosa, Streptococcus pneumoniae, Aspergillus flavus, A. niger, Fusarium oxysporum, andLasiodiplodia theobromae. In vitro the fungi showed sensitivity in decreasing order to fluctytosine, nystatin, amphotericin B and econazole. Due to the out-patient status of the patients, their in-vivo response to treatment was not assessable.

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References

  1. 1.

    Chin GN, Hundiuk RA, Kwasny GP, Schultz GP. Keratomycosis in Wisconsin. Am J Ophthalmol 1975; 79: 121–25.

  2. 2.

    Nityananda K, Sivasubramaniam P, Ajello L. Mycotic keratitis caused byCurvularia lunata. Sabouraudia 1962; 2: 35–9.

  3. 3.

    Nityananda K, Sivasubramaniam P, Ajello L. A case of mycotic keratitis caused byCurvularia geniculata. Arch Ophthalmol 1964; 71: 456–8.

  4. 4.

    Cowan ST, Steel KJ. Manual for the identification of medical bacteria, 2nd ed. Cambridge: Cambridge University Press, 1974.

  5. 5.

    Casals JB. Tablet sensitivity testing of pathogenic fungi. J Clin Pathol 1979; 32: 719–22.

  6. 6.

    Jones DB. Pathogenesis of bacterial and fungal keratitis. Trans Ophthalmol Soc UK 1978; 98: 367–71.

  7. 7.

    Fedukowic HB, Stenson S. External infections of the eye. Norwalk: Appleton, Century and Crofts, 1985: 61.

  8. 8.

    Samson RA.Paecilomyces. Baarn: Centraalbureau voor Schimmelcultures, 1974.

  9. 9.

    Ferron P, Fargues J, Riba G. Fungi as microbial insecticides against pests. In: Arora DK, Ajello L, Mukerji KG, eds. Handbook of applied mycology, Vol. 2: Humans, animals and insects. New York/Basel/Hong Kong: Marcel Dekker, 1991: 665–706.

  10. 10.

    Bruno DW. Observations on a swim bladder fungal infection of farmed Atlantic salmon,Salmo salar L. Bull Assoc Eur Fish Pathol 1989; 9: 7–8.

  11. 11.

    Thygeson P, Okumoto M. Keratomycosis: A preventable disease. Trans Am Acad Ophthalmol Otolaryngol 1974; 8: 433–9.

  12. 12.

    Puttanna ST. In Trans Asia-Pacific Acad Ophthalmol 1964; 2: 298–305, cited in Ophthalmic Literature, 1965.

  13. 13.

    Kaufman E, Wood RM. Mycotic keratitis. Am J Ophthalmol 1965; 59: 993–1000.

  14. 14.

    Newmark E, Ellison AC, Kaufman HE. Pimaricin therapy ofCephalosporium andFusarium keratitis. Am J Ophthalmol 1970; 69: 458–66.

  15. 15.

    Wood TO, Williford W. Treatment of keratitis with amphotericin B 0.15%. Am J Ophthalmol 1976; 75: 847–49.

  16. 16.

    Flynn JR.Fusarium keratitis treated with cycloheximide. Am J Ophthalmol 1964; 58: 637–41.

  17. 17.

    Iwata K. Drug resistance in human pathogenic fungi. Eur J Epidemiol 1992; 8: 407–21.

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Correspondence to Professor Sarath N. Arseculeratne.

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Gonawardena, S.A.S., Ranasinghe, K.P., Arseculeratne, S.N. et al. Survey of mycotic and bacterial keratitis in Sri Lanka. Mycopathologia 127, 77–81 (1994). https://doi.org/10.1007/BF01103062

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Key words

  • Bacteria
  • Drug sensitivity
  • Fungi
  • Keratitis
  • Paecilomyces farinosus