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Mycopathologia

, Volume 131, Issue 2, pp 121–126 | Cite as

Ochratoxin A and aflatoxins in breast milk samples from Sierra Leone

  • Felixtina E. Jonsyn
  • Sheila M. Maxwell
  • Ralph G. Hendrickse
Mycotoxi Coses And Mycotoxins

Abstract

Breast milks from 113 mothers in two ‘Under-Five Clinics’ in the Southern Province of Sierra Leone, namely, Njala and Bo, were examined for their mycotoxin content. Only 10 were mycotoxin-free. Eighty-eight per cent of samples contained various aflatoxins and 35% contained ochratoxin A (OTA). Few samples (15%) had a single mycotoxin. Thirty-six (32%) had two mycotoxins and 50 (40%) had three or more. The occurrence of OTA in combination with various aflatoxins was recorded. It is concluded that infants in Sierra Leone are exposed to OTA and aflatoxins at levels which in some cases far exceed those permissible in animal feed in developed countries.

Key words

Aflatoxin Breast milk Ochratoxin A Sierra Leone 

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References

  1. 1.
    Allcroft R, Carnaghan RBA. Groundnut toxicity.Aspergillus flavus toxin (aflatoxin) in animal products: preliminary communication. Vet Rec 1962; 74: 863–64.Google Scholar
  2. 2.
    Holzapfel CW, Steyn PS, Purchase IFH. Isolation and structure of aflatoxins M1 and M2. Tetrahedron Letters 1966; 25: 2799–803.PubMedGoogle Scholar
  3. 3.
    Van Egmond HP (ed), Mycotoxin in Dairy Products. London, New York: Elsevier Applied Science, 1989.Google Scholar
  4. 4.
    Trucksess MW, Stoloff L. High performance liquid chromatography: determination of aflatoxical in milk, blood and liver. J Assoc Off Anal Chem 1981; 64: 1083–87.PubMedGoogle Scholar
  5. 5.
    Coulter JBS, Lamplugh SM, Suliman GI, Omer MIA, Hendrickse RG. Aflatoxins in human breast milk. Annals Trop Paediatr 1984; 4: 61–6.Google Scholar
  6. 6.
    Maxwell SM, Apeagyei F, De Vries HR, Mwanmut DD, Hendrickse RG. Aflatoxins in breast milk, neonatal cord blood and sera of pregnant women. J Toxicol — Toxin Reviews 1989; 8(1–2): 19–29.Google Scholar
  7. 7.
    Zarba A, Wild CP, Hall AJ, Montesano R, Hudson GJ, Groopman JD. Aflatoxin M1 in human breast milk from the Gambia, West Africa, Quantified by combined monoclonal antibody immunoaffinity chromatography and HPLC. Carcinogenesis 1992; 13: 891–94.PubMedGoogle Scholar
  8. 8.
    Yadgiri B, Reddy V, Talpule PG, Srikantia SG, Gopalan C. Aflatoxin and Indian childhood cirrhosis. Am J Clin Nutr 1970: 23: 94–8.PubMedGoogle Scholar
  9. 9.
    Campbell TC, Caedo JP, Bulatao-Jayme J, Salamet L, Engel RW. Aflatoxin M1 in human urine. Nature 1970; 227: 403–4.PubMedGoogle Scholar
  10. 10.
    Galtier P, Alvinerie M, Charpentau JL. The pharmacokenetic profiles of ochratoxin A in pigs, rabbits and chickens. Fd Cosmet Toxicol 1981; 19: 737–38.Google Scholar
  11. 11.
    Ribelin WE, Fukushima K, Still P. The toxicity of ochratoxin A to ruminants. Can J Comp Med 1978; 42: 172–76.Google Scholar
  12. 12.
    Breitholtz-Emanuelsson A, Olsen M, Oskarsson A, Palminger I, Hult K. Ochratoxin A in cow's milk and in human milk with corresponding human blood samples. J Assoc Off Anal Chem 1993; 42: 172–76.Google Scholar
  13. 13.
    Gareis M, Martlbauer E, Bauer J, Gedek B. Determination of ochratoxin A in breast milk. Z. Lebensm Unters Forsch 1988; 186: 114–17.PubMedGoogle Scholar
  14. 14.
    Micco C, Ambruzzi MA, Miraglia M, Breva C, Onori R, Benelli L. Contamination of human milk with ochratoxin A. In: Castegnaro M, Plestina R, Dirheimer G, Chernozemsky N, Bartsch H (eds), Mycotoxina, endemic nephropathy and urinary tract tumours. Lyon: IARC Scientific Publications No 115, 1991: 105–8.Google Scholar
  15. 15.
    Jonsyn FE. Seedborne fungi of sesame (Sesamun indicum L.) in Sierra Leone and their potential aflatoxin/mycotoxin production. Mycopathologia 1988; 104: 123–27.PubMedGoogle Scholar
  16. 16.
    Jonsyn FE. Fungi associated with selected fermented foods in Sierra Leone. Mircen J 1989; 5: 457–62.Google Scholar
  17. 17.
    Jonsyn FE. Mycological contamination of Ogiri (fermented sesame seeds) during production in Sierra Leone. Mycopathologia 1990;110:113–17.PubMedGoogle Scholar
  18. 18.
    Jonsyn FE, Lahai GP. Mycotoxic flora and mycotoxins in smoke-dried fish from Sierra Leone. Die Nahrung 1992; 36: 485–89.PubMedGoogle Scholar
  19. 19.
    Jonsyn FE, Maxwell SM. Detection of ochratoxin A and aflatoxin in food samples from Sierra Leone. In: Creppy EE, Castegnaro M, Dirheimer G (eds), International symposium on human ochratoxicosis and associated pathologies in Africa and developing countries. INSERM 231: Sup John Libbey and Co, 1993: 4–6.Google Scholar
  20. 20.
    Kuiper-Goodman T, Scott PM. Review-risk assessment of the mycotoxin Ochratoxin A. Biomed Environ Sci 1989; 2: 179–248.PubMedGoogle Scholar
  21. 21.
    Wild CP, Pionneau FA, Montesano R, Mutiro CF, Chetsanga CJ. Aflatoxin detected in human breast milk by immunoassay. Int J Cancer 1987; 40: 328–33.PubMedGoogle Scholar
  22. 22.
    Kane A, Diop N, Diack TS. Natural occurrence of ochratoxin A in food and feedstuffs in Senegal. In: Castegnaro M, Plestina R, Dirheimer G, Chernozemsky N, Bartsch H (eds), Mycotoxins, endemic nephropathy and urinary tract tumours. Lyon: IARC Scientific Publications No 116, 1991: 93–96.Google Scholar
  23. 23.
    Van Rensburg SJ, Cook-Mozaffari P, Van Schalkwyk CJ, Van der Watt JJ, Vincent TJ, Purchase IFH. Hepatocellular carcinoma and dietary aflatoxin in Mozambique and Transkei. Brit J Cancer 1985; 51: 713–26.PubMedGoogle Scholar
  24. 24.
    Hendrickse RG. Epidemiology and control of renal diseases in Africa. Trans Roy Soc Trop Med Hyg 1980; 74: 8–16.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1995

Authors and Affiliations

  • Felixtina E. Jonsyn
    • 1
  • Sheila M. Maxwell
    • 2
  • Ralph G. Hendrickse
    • 3
  1. 1.Department of Biological SciencesUniversity of Sierra Leone, Njala University CollegeSierra Leone
  2. 2.Liverpool John Moores UniversityLiverpoolUK
  3. 3.University of LiverpoolLiverpoolUK

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