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Biotechnology Letters

, Volume 10, Issue 6, pp 389–392 | Cite as

Improved stability of the continuous production of acetone-butanol by Clostridium acetobutylicum in a two-stage process

  • C. Godin
  • J. M. Engasser
Article

Abstract

A stable continuous culture has been maintained for 30 days at a high 20 g/l solvent concentration. This substantial increase in the stability of the continuous culture ofClostridium acetobutylicum at the maximal solvent level was achieved by using a two-stage process with a dilution rate of 0.1 h−1 in the first fermentor and 0.04 h−1 in the second fermentor. The two-stage continuous fermentation allows an optimal growth of cells and induction of solvent metabolism in the first stage, and a maximal production yield of solvents in the second stage.

Keywords

Fermentation Production Yield Clostridium Optimal Growth Dilution Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • C. Godin
    • 1
  • J. M. Engasser
    • 1
  1. 1.Laboratoire des Sciences du Génie ChimiqueCNRS-ENSIC-ENSAIA Institut National Polytechnique de LorraineNancy CedexFrance

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