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Measurement of cardiac output with first-pass determination during rubidium-82 PET myocardial perfusion imaging

Abstract

In addition to providing useful clinical information, cardiac output determined during rubidium-82 positron emission tomography (PET) myocardial perfusion studies can be used in the measurement of absolute regional myocardial blood flow using Sapirstein's method. This investigation was conducted to compare cardiac output values obtained by post-processing data acquired in a list mode PET myocardial perfusion study with those obtained using a technetium-99m-labeled red blood cell method on the same patients. Results from 14 patients showed that cardiac output can be accurately measured simultaneously in a82Rb PET myocardial study, allowing determination of multiple perfusion and functional parameters of the heart, thus improving the cost-effectiveness of the82Rb PET study.

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References

  1. 1.

    Sapirstein LA. Regional blood flow by fractional distribution of indicators.Am J Physiol 1958; 193: 161–168.

  2. 2.

    Chen EQ, MacIntyre WJ, Go RT, Wong CYO, Fouad FM, Neumann DR. Quantitative resting myocardial blood flow measurement by Rb-82 PET: Sapirstein's method compared to twocompartmental model [abstract].J Nucl Med 1995; 36: 37P.

  3. 3.

    Hamilton WF, Riley RL, Attyah AM, et al. Comparison of the Fick and dye injection methods of measuring the cardiac output in man.Am J Physiol 1958; 153: 309–321.

  4. 4.

    Thompson HK, Starmer CF, Whalen RE, et al. Indicator transit time considered as a gamma variate.Circ Res 1964; 14: 502–525.

  5. 5.

    Fouad-Tarazi FM, MacIntyre WJ. Radionuclide methods for cardiac output determination.Eur Heart J 1990; 11 Suppl 1; 33–40.

  6. 6.

    Krivokapich J, Smith GT, Huang SC, Hoffman EJ, Ratib O, Phelps ME, Schelbert HR.13N ammonia myocardial imaging as rest and with exercise in normal volunteers: quantification of absolute myocardial perfusion with dynamic positron emission tomography.Circulation 1990; 80: 1328–1337.

  7. 7.

    Mullani NA, Goldstein RA, Gould KL, Marani SK, Fisher DJ, O'Brien HA Jr, Loberg MD. Myocardial perfusion with rubidium-82. I. Measurement of extraction fraction and flow with external detectors.J Nucl Med 1983; 24: 898–906.

  8. 8.

    Chen EQ, MacIntyre WJ, Go RT, Brunken RC, Neumann DR, Fouad FM, Kaczur T. The left ventricular ejection fraction measurement using geometric volume method from ECG-gated list mode myocardial perfusion Rb-82 PET imaging [abstract].J Nucl Med 1995; 36: 91P.

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Correspondence to Eric Q. Chen.

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Chen, E.Q., Maclntyre, W.J., Fouad, F.M. et al. Measurement of cardiac output with first-pass determination during rubidium-82 PET myocardial perfusion imaging. Eur J Nucl Med 23, 993–996 (1996). https://doi.org/10.1007/BF01084378

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Key words

  • Cardiac output
  • Rubidium-82
  • Positron emission tomography