Molecular and Cellular Biochemistry

, Volume 127, Issue 1, pp 201–209

The MAP kinase cascade. Discovery of a new signal transduction pathway

  • Natalie G. Ahn
Protein Phosphorylation in Signal Transduction


Using biochemical techniques similar to those used by Krebs and Fischer in elucidating the cAMP kinase cascade, a protein kinase cascade has been found that represents a new pathway for signal transduction. This pathway is activated in almost all cells that have been examined by many different growth and differentiations factors suggesting control of different cell responses. At this writing, four tiers of growth factor regulated kinases, each tier represented by more than one enzyme, have been reconstitutedin vitro to form the MAP kinase cascade. Preliminary findings suggesting multiple feedback or feedforward regulation of several components in the cascade predict higher complexity than a simple linear pathway.

Key words

mitogen activated protein kinase kinase cascade growth factor protein phosphorylation signal transduction 


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Copyright information

© Kluwer Academic Publishers 1993

Authors and Affiliations

  • Natalie G. Ahn
    • 1
  1. 1.Department of Chemistry and BiochemistryUniversity of ColoradoBoulderUSA

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