Molecular and Cellular Biochemistry

, Volume 127, Issue 1, pp 51–70 | Cite as

Autophosphorylation: a salient feature of protein kinases

  • Jeffrey A. Smith
  • Sharron H. Francis
  • Jackie D. Corbin
Protein Kinases


Most protein kinases catalyze autophosphorylation, a process which is generally intramolecular and is modulated by regulatory ligands. Either serine/threonine or tyrosine serves as the phosphoacceptor, and several sites on the same kinase subunit are usually autophosphorylated. Autophosphorylation affects the functional properties of most protein kinases. Members of the protein kinase family exhibit diversity in the characteristics and functions of autophosphorylation, but certain common themes are emerging.

Key words

protein kinases autophosphorylation protein phosphorylation post-translational modification regulation SH2 domains 


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Copyright information

© Kluwer Academic Publishers 1993

Authors and Affiliations

  • Jeffrey A. Smith
    • 1
  • Sharron H. Francis
    • 1
  • Jackie D. Corbin
    • 1
  1. 1.Department of Molecular Physiology and BiophysicsVanderbilt University School of MedicineNashvilleUSA

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