The American Journal of Digestive Diseases

, Volume 18, Issue 6, pp 455–459 | Cite as

Bile acid secretion and biliary bile acid composition altered by cholecystectomy

  • Juan R. Malagelada
  • Vay Liang W. Go
  • William H. J. Summerskill
  • Willard S. Gamble
Original Articles


After cholecystectomy, bile secretion is continuous and 24-hour bile acid output exceeds that in health. Cholecystokinin-pancreozymin (CCK-PZ) influences neither bile acid secretion nor the bile acid composition of bile after the operation. It is proposed that the absence of the gallbladder causes more rapid enterohepatic recycling of bile acids and therefore increased bile acid secretion. The bile acid composition of bile following cholecystectomy is abnormal for the same reasons. A high proportion of secondary bile acids is present, including several found to be keto bile acids, and this is attributed to increased exposure of the bile acid pool to degradation by intestinal microorganisms.


Public Health Acid Composition Bile Acid Acid Secretion Acid Output 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Medical Department Harper & Row, Publishers, Inc. 1973

Authors and Affiliations

  • Juan R. Malagelada
    • 1
    • 2
  • Vay Liang W. Go
    • 1
    • 2
  • William H. J. Summerskill
    • 1
    • 2
  • Willard S. Gamble
    • 1
    • 2
  1. 1.Gastroenterology UnitMayo ClinicRochester
  2. 2.Mayo FoundationRochester

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