Journal of Near-Death Studies

, Volume 7, Issue 4, pp 205–222 | Cite as

A neurobiological model for near-death experiences

  • Juan C. Saavedra-Aguilar
  • Juan S. Gómez-Jeria


The authors present a neurobiological model for near-death experiences (NDEs) in an attempt to correlate the biological and psychological domains. This model is based on temporal lobe dysfunction, hypoxia/ischemia, stress, and neuropeptide/neurotransmitter imbalance. They describe and discuss the fundamental contribution of the language system in the construction of verbal reports of NDEs. This model could be seen as a complement to other explanatory domains.


Temporal Lobe Verbal Report Language System Psychological Domain Fundamental Contribution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Abramovitch, H. (1988). An Israeli account of a near-death experience: A case study of cultural dissonance,Journal of Near-Death Studies, 6, 175–184.Google Scholar
  2. Almond, P. C. (1982).Mystical experience and religious doctrine. Berlin: Mouton Publishers.Google Scholar
  3. Babb, T. L. Wilson, C. L., and Isokawa-Akesson, I. (1987). Firing patterns of human limbic neurons during stereoencephalography (SEEG) and clinical temporal lobe seizures.Electroencephalography and Clinical Neurophysiology, 66, 467–482.Google Scholar
  4. Brooks, S., Burrin, J., Cheetaw, M. E., Hall, G. M. Yeo, T., and Williams, C. (1988). The responses of the catecholamines and β-endorphin to brief maximal exercise in man.European Journal of Applied Physiology and Occupational Physiology, 57, 230–234.Google Scholar
  5. Caplan, R. M. (1986).Exploring the concept of mind. Iowa City, IA: University of Iowa Press.Google Scholar
  6. Carr, D. B. (1981). Endorphins at the approach of death.Lancet, 1, 390.Google Scholar
  7. Carr, D. B. (1982). Pathophysiology of stress-induced limbic lobe dysfunction: An hypothesis for NDEs.Anabiosis: The Journal of Near-Death Studies, 2, 75–89.Google Scholar
  8. Clark, W. C., Yang, J. C., and Janal, M. N. (1984). Altered pain and visual sensitivity in humans: The effects of acute and chronic stress.Annals of the New York Academy of Science, 467, 116–129.Google Scholar
  9. Critchley, M. (1979).The divine banquet of the brain. New York, NY: Raven Press. pp. 1–12.Google Scholar
  10. Dingledine, R., Hynes, M. A., and King, G. L. (1986). Involvement of N-methyl-D-aspartate receptors in epileptiform bursting in the rat hippocampal slice.Journal of Physiology, 380, 175–189.Google Scholar
  11. Eliade, M. (1964).Shamanism: Archaic techniques of ecstasy (W. R. Trask, trans.). Princeton, NJ: Princeton University Press.Google Scholar
  12. Efron, R. (1963). Temporal perception, aphasia and déjà vu.Brain, 86, 403–424.Google Scholar
  13. Fagg, G. E. (1985). L-glutamate, excitatory aminoacid receptors and brain function.Trends in Neuroscience, 8, 207–210.Google Scholar
  14. Frederiks, J. A. M. (1969). Disorders of the body schema. pp. 207–240 in P. J. Vinken and G. W. Bruyn (Eds.),Handbook of clinical neurology. Vol. 4: Disorders of speech, perception, and symbolic behavior. New York. NY: American Elsevier Publ. Co.Google Scholar
  15. Frederiks, J. A. M. (1985). Paroxysmal neuropsychological disorders. pp. 507–514 in P. J. Vinken, G. W. Bruyn, H. I. Klawans, and J. A. M. Frederiks (Eds.),Handbook of clinical neurology, Vol. 45 (Revised series vol. 1): Clinical neuropsychology New York, NY: Elsevier Science Publ. Co.Google Scholar
  16. Fujiwara, N., Higashi, H., Shimoki, K., and Yoshimura, M. (1987). Effects of hypoxia on rat hippocampal neurons in vitro.Journal of Physiology, 384, 131–151.Google Scholar
  17. Gabbard, G. O., Twemlow, S. W., and Jones, F. C. (1981). Do “near-death experiences” occur only near death?Journal of Nervous and Mental Disease, 169, 374–377.Google Scholar
  18. Gazzaniga, M. S. (1985).The social brain. New York, NY: Basic Books.Google Scholar
  19. Gazzaniga M. S., and LeDoux, J. E. (1985).The integrated mind. New York, NY: Plenum Press.Google Scholar
  20. Gellman, R., and McNamara, I. (1984). Selective depletion of norepinephrine with the neurotoxin DSP4 facilitates kindling development in rats.Society for Neuroscience, 10, 343.Google Scholar
  21. Gibson, G. E., and Blaas, J. P. (1979). Proportional inhibition of acetylcholine synthesis accompanying mild hypoxia and hypoglycemia.Journal of Neurochemistry, 27, 37–42.Google Scholar
  22. Glennon, R. A. (1985). Involvement of serotonin in the action of hallucinogenic drugs. In R. A. Green (Ed.),Neuropharmacology of serotonin. Oxford, England: Oxford University Press.Google Scholar
  23. Gloor, P. (1982). Temporal lobe epilepsy: Its possible contributions to the understanding of the functional significance of the amygdala and of its interaction with neocorticaltemporal mechanisms. Pp. 423–457 in B. E. Eleftherion (Ed.),The neurobiology of the amygdala. New York, NY: Plenum Press.Google Scholar
  24. Gloor, P., Olivier, A., Quesney, L. F., Andermann, F., and Horowitz, S. (1982). The role of the limbic system in experiential phenomena of temporal lobe epilepsy.Annals of Neurology, 12, 129–144.Google Scholar
  25. Greyson, B. (1981). Toward a psychological explanation of near-death experiences: A response to Dr. Grosso's paper.Anabiosis: The Journal of Near-Death Studies, 1, 88–103.Google Scholar
  26. Greyson, B. (1983a). The Near-Death Experience Scale: Construction, reliability, and validity.Journal of Nervous and Mental Disease, 171, 369–375.Google Scholar
  27. Greyson, B. (1983b). The psychodynamics of near-death experiences.Journal of Nervous and Mental Disease, 171, 376–381.Google Scholar
  28. Greyson, B. (1985). A typology of near-death experiences.American Journal of Psychiatry, 142, 967–969.Google Scholar
  29. Greyson, B., and Stevenson, I. (1980). The phenomenology of near-death experiences.American Journal of Psychiatry, 137, 1193–1196.Google Scholar
  30. Grosso, M. (1981). Toward an explanation of near-death phenomena.Anabiosis: The Journal of Near-Death Studies, 1, 3–26.Google Scholar
  31. Gupta, A. R., Jeavons, P. M., Hughes, R. C., and Covanis, A. (1983). Aura in temporal lobe epilepsy: Clinical and electroencephalographic correlations.Journal of Neurology, Neurosurgery, and Psychiatry, 46, 1079–1083.Google Scholar
  32. Halgren, E., Walter, R. D., Cherlow, D. G., and Crandall, P. H. (1978). Mental phenomena evoked by electrical stimulation of the human hippocampal formation and amygdala.Brain, 101, 83–117.Google Scholar
  33. Halgren, E., and Wilson, C. L. (1985). Recall deficits produced by afterdischarges in the human hippocampal formation and amygdala.Electroencephalography and clinical Neurophysiology, 61, 375–380.Google Scholar
  34. Hausser-Hauw, C., and Bancaud, J. (1987). Gustatory hallucinations in epileptic seizures.Brain, 110, 339–359.Google Scholar
  35. Henriksen, S. J., Bloom, F. E., McCoy, F., Ling, N., and Guillemin, R. (1978). β-endorphin induces non-convulsive limbic seizures.Proceedings of the National Academy of Sciences, 75, 5221–5225.Google Scholar
  36. Hiller, J. M., Itzhak, Y., and Simon, E. J. (1986). Limbic regions of the brain of Alzheimer's disease patients show selective changes in mu, delta and kappa opioid receptor binding.NIDA Research Monographs, 75, 559–562.Google Scholar
  37. Hong, C. H., Woo, J. I., Suh, Y. H., Park, C. W., and Lee, C. K. (1987). Effect of ketamine on the acetylcholine concentration of various regions of rat brain.Seoul Journal of Medicine, 28, 347–351.Google Scholar
  38. Isaacson, R. L. (1982).The limbic system. New York, NY: Plenum Press.Google Scholar
  39. James, W. (1890).Principles of psychology. New York, NY: Holt.Google Scholar
  40. Janz, D. (1986). Epilepsy, viewed metaphysically: An interpretation of the Biblical story of the epileptic boy and of Raphael's Transfiguration.Epilepsia, 27, 316–322.Google Scholar
  41. Kelly, D. D. (1982). The role of endorphins in stress-induced analgesia.Annals of the New York Academy of Science, 398, 260–271.Google Scholar
  42. Judson, I. R., and Wiltshaw, E. (1983). A near-death experience.Lancet, 2, 561–562.Google Scholar
  43. Kissin, B. (1986).Conscious and unconscious programs in the brain. New York, NY: Plenum Press.Google Scholar
  44. Kroll, J., and Bachrach, B. (1982). Visions and psychopathology in the Middle Ages.Journal of Nervous and Mental Disease, 170, 41–49.Google Scholar
  45. Landsborough, D. (1987). St. Paul and temporal lobe epilepsy.Journal of Neurology, Neurosurgery, and Psychiatry, 50, 659–664.Google Scholar
  46. Leitner, D. S. (1984). Alteration in other sensory modalities accompanying stress analgesia as measured by startle reflex modification.Annals of the New York Academy of Science, 467, 82–92.Google Scholar
  47. Lukianowicz, N. (1958). Autoscopic phenomena,Archives of Neurology, 80, 199–220.Google Scholar
  48. Masters, R. E. L., and Houston, J. (1967).The varieties of psychedelic experience. New York, NY: Dell.Google Scholar
  49. McGinty, J. F., Kanamatsu, T., Obie, J., and Hong, J. S. (1986). Modulation of opioid peptide metabolism by seizures: differentiation of opioid subclasses.NIDA Research Monographs, 71, 89–101.Google Scholar
  50. McIntosh, T. K., Fernyak, S., and Faden, A. I. (1986). Endogenous peptides, opiate receptors and traumatic brain injury.NIDA Research Monographs, 75, 527–530.Google Scholar
  51. Mclean, S., Rothman, R. B., and Herkenham, M. (1986). Autoradiographic localization of μ-and δ-opioid receptors in the forebrain of the rat.Brain Research, 378, 49–60.Google Scholar
  52. Mesulam, M. M. (1981). Dissociative states with abnormal temporal lobe EEG.Archives of Neurology, 38, 176–181.Google Scholar
  53. Mesulam, M., and Appenzeller, T. (1987). The anatomy of memory.Scientific American, 256, 62–71.Google Scholar
  54. Modai, I., and Cygielman, G. (1986). Conversion hallucinations: A possible mental mechanism.Psychopathology, 19, 324–326.Google Scholar
  55. Naranjo, C. (1973). Psychological aspects of the Yagé experience in an experimental setting. In M. J. Harner (Ed.),Hallucinations and shamanism. London, England: Oxford University Press.Google Scholar
  56. Neumaier, J. F., Mailheau, S., and Chavkin, C. (1988). Opioid receptor-mediated responses in the dentate gyrus and CA1 regions of the rat hippocampus.Journal of Pharmacology and Experimental Therapeutics, 244, 564–570.Google Scholar
  57. Pardes, H. (1980). Neuroscience and psychiatry: Marriage or coexistence?American Journal of Psychiatry, 143, 1205–1212.Google Scholar
  58. Pasricha, S., and Stevenson, I. (1986). Near-death experiences in India.Journal of Nervous and Mental Disease, 174, 165–170.Google Scholar
  59. Penfield, W. (1955). The role of the temporal cortex in certain psychical phenomena.Journal of Mental Science, 101, 451–465.Google Scholar
  60. Plum F., and Pulsinelly, W. A. (1986). Cerebral metabolism and hypoxic-ischemic brain injury. pp. 1086–1100 in A. K. Asbury, G. M. McKhann, and W. I. McDonald (Eds.),Diseases of the nervous system, Vol. 2. Philadelphia, PA: Ardmore Medical Books.Google Scholar
  61. Ravagnati, L., Halgren, E., Babb, T. L., and Crandall, P. H. (1977). Activity of human hippocampal formation and amygdala neurons during sleep.Neuroscience Abstracts, 3, 471.Google Scholar
  62. Rayport, M., and Ferguson, S. M. (1974). Qualitative modifications of sensory responses to amygdaloid stimulation in man by interview content and context.Electroencephalography and Clinical Neurophysiology, 34, 714.Google Scholar
  63. Ring, K. (1980).Life at death: A scientific investigation of the near-death experience. New York, NY: Coward, McCann and Geoghegan.Google Scholar
  64. Rogo, D. S. (1984). Ketamine and the NDE.Anabiosis: The Journal of Near-Death Studies, 4, 87–96.Google Scholar
  65. Saavedra-Aguilar, J. C. and Gómez-Jeria, J. S. (1987). Towards a neurobiological model of self-consciousness.Revista Chilena de Neuro-Psiquiatria, 25, 247–251.Google Scholar
  66. Sabom, M. S. (1982).Recollections of death: A medical investigation. New York, NY: Harper and Row.Google Scholar
  67. Sabom, M. S., and Kreutziger, S. (1977a). The experience of near-death.Death Education, 1, 195–203.Google Scholar
  68. Sabom, M. S., and Kreutziger, S. (1977b). Near-death experiences.New England Journal of Medicine, 297, 1071.Google Scholar
  69. Saunders, R. C., and Rosene, D. L. (1988). A comparison of the afferents of the amygdala and the hippocampal formation in the Rhesus monkey. I: Convergence in the entorhinal, prorhinal and perirhinal cortices.Journal of Comparative Neurology, 271, 153–184.Google Scholar
  70. Saunders, R. C., Rosene, D. L., and Van Hoesen, G. W. (1988). Comparison of the efferents of the amygdala and the hippocampal formation in the Rhesus monkey. II: Reciprocal and non-reciprocal connections.Journal of Comparative Neurology, 271, 185–207.Google Scholar
  71. Schenk, L., and Bear, D. (1981). Multiple personality and related dissociative phenomena in patients with temporal lobe epilepsy.American Journal of Psychiatry, 138, 1311–1316.Google Scholar
  72. Seifert, W. (1983).neurobiology of the hippocampus. New York, NY: Academic Press.Google Scholar
  73. Siegel, R. (1980). The psychology of life after death.American Psychologist, 35, 911–931.Google Scholar
  74. Siegel, R., and Hirschman, A. (1984). Hashish near-death experiences.Anabiosis: The Journal of Near-Death Studies, 4, 69–89.Google Scholar
  75. Siesjo, B. K., and Wieloch, T. (1986). Epileptic brain damage: Pathophysiology and neurochemical pathology. pp. 813–855 in A. V. Delgado-Escueta, A. A. Ward, D. M. Woodbury, and R. J. Porter (Eds.),Advances in Neurology, Vol. 44, New York, NY: Raven Press.Google Scholar
  76. Taylor, D. C., and Lochery, M. (1987). Temporal lobe epilespsy: Origin and significance of simple and complex auras.Journal of Neurology, neurosurgery, and Psychiatry, 50, 673–681.Google Scholar
  77. Tobacyk, J. J., and Mitchell, T. O. (1987). The out-of-body experience and personality adjustment.Journal of Nervous and Mental Disease, 175, 367–370.Google Scholar
  78. Tulving, E. (1987). Multiple memory systems and consciousness.Human Neurobiology, 6, 67–80.Google Scholar
  79. Van Eeden, F. (1969). A study of dreams. pp. 145–158 in C. Tart (Ed.),Altered states of consciousness. New York, NY: John Wiley.Google Scholar
  80. Webb, W. B., and Cartwright, R. D. (1978). Sleep and dreams.Annual Review of Psychology, 29, 223–252.Google Scholar
  81. Wieser, H. G. (1983). Depth recorded limbic seizures and psychopathology.Neuroscience and Biobehavioral Reviews, 7, 427.Google Scholar
  82. Woodbury, D. (1984). Neurotransmitters and epilepsy: Distinguishing characteristics and unifying concepts.Federation Proceedings, 43, 2529–2531.Google Scholar
  83. Zimberg, N. E. (1977).Alternate states of consciousness. London, England: Free Press.Google Scholar

Copyright information

© Human Sciences Press 1989

Authors and Affiliations

  • Juan C. Saavedra-Aguilar
    • 1
  • Juan S. Gómez-Jeria
    • 2
  1. 1.Facultad de Medicina, Departamento de Ciencias NeurologicasUniversidad de ChileSantiagoChile
  2. 2.Facultad de Ciencias, Departamento de QuimicaUniversidad de ChileSantiagoChile

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