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The Maudsley Reactive and Nonreactive strains of rats: A survey

Abstract

Experiments with two strains of rats, the Maudsley Reactive and Nonreactive, developed in London, England, and which were performed during 1964–1974 by a variety of investigators are summarized in a table. It is concluded that the results support the strains' standing as exemplars of differences in emotional reactivity.

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References

  1. Archer, J. (1973). Tests for emotionality in rats and mice: A review.Anim. Behav. 21:205–235.

  2. Bailey, B. F. S., and Heald, P. J. (1961). The separation of the cytoplasmic proteins of brain by electrophoresis in a starch gel medium.J. Neurochem. 6:342–349.

  3. Benešová, O., and Beneš, V. (1968). The relation between the type of higher nervous activity, some biochemical parameters and the reactivity to drugs.Act. Nerv. Super. 10:223–231.

  4. Bernet, F. (1974). Personal communication.

  5. Blizard, D. A. (1970). The Maudsley strains: The evaluation of a possible artifact.Psychon. Sci. 19:145–146.

  6. Blizard, D. A. (1971). Autonomic activity in the rat: Effects of genetic selection for emotionality.J. Comp. Physiol. Psychol. 76:282–289.

  7. Blizard, D. A. (1975). Colonic reactivity in curarized rats of the MR and MNR strains: Differential response to novel stimuli and classical conditioning procedures.Behav. Genet. 5:90 (abst.).

  8. Brewster, D. J. (1968). Genetic analysis of ethanol preferences in rats selected for emotional reactivity.J. Hered. 5:283–286.

  9. Brewster, D. J. (1969). Ethanol preference in strains of rats selectively bred for behavioral characteristics.J. Genet. Psychol. 115:217–227.

  10. Brewster, D. J. (1972). Ethanol preference in strains of rats selectively bred for behavioral characteristics.Ann. N. Y. Acad. Sci. 197:49–53.

  11. Broadhurst, P. L. (1957). Determinants of emotionality in the rat. I. Situational factors.Brit. J. Psychol. 48:1–12.

  12. Broadhurst, P. L. (1958a). Determinants of emotionality in the rat. II. Antecedent factors.Brit. J. Psychol. 49:12–20.

  13. Broadhurst, P. L. (1958b). Studies in psychogenetics: The quantitative inheritance of behavior in rats investigated by selective and cross-breeding.Bull. Brit. Psychol. Soc. 34:2A (abst.).

  14. Broadhurst, P. L. (1960). Experiments in psychogenetics: Applications of biometrical genetics to the inheritance of behaviour. In Eysenck, H. J. (ed.)Experiments in Personality, Vol. I:Psychogenetics and Psychopharmacology, Routledge and Kegan Paul, London, pp. 1–102.

  15. Broadhurst, P. L. (1962). A note on further progress in a psychogenetic selection experiment.Psychol. Rep. 10:65–66.

  16. Broadhurst, P. L. (1963). The choice of animal for behavior studies.L.A.C. Coll. Papers 12:65–80.

  17. Broadhurst, P. L. (1964). The hereditary base for action of drugs on animal behaviour. In Steinberg, H., de Reuck, A. V. S., and Knight, J. (eds.),Animal Behaviour and Drug Action, Ciba Foundation Symposium jointly with Co-ordinating Committee for Symposia on Drug Action, Churchill, London, pp. 224–236.

  18. Broadhurst, P. L. (1966). Behavioral inheritance: Past and present.Cond. Reflex 1:3–15.

  19. Broadhurst, P. L. (1967). The biometrical analysis of behavioural inheritance.Sci. Progr. 55:123–139.

  20. Broadhurst, P. L. (1970). Psikhogenetika i biometricheskii analiz nasledovaniya u krysy.Genetika 6:91–99.

  21. Broadhurst, P. L. (1973). Unpublished data.

  22. Broadhurst, P. L., and Eysenck, H. J. (1965). Emotionality in the rat: A problem of response specificity. In: Banks, C. and Broadhurst, P. L. (eds.),Stephanos: Studies in Psychology Presented to Cyril Burt, University of London Press, London, pp. 202–221.

  23. Broadhurst, P. L., and Wallgren, H. (1964). Ethanol and the acquisition of a conditioned response in selected strains of rats.Quart. J. Stud. Alcohol 25:476–489.

  24. Broadhurst, P. L., and Watson, R. H. J. (1964). Brain cholinesterase, body build and emotionality in different strains of rats.Anim. Behav. 12:42–51.

  25. Chamove, A. (1974). Personal communication.

  26. Eller, G. (1974). Personal communication.

  27. Eysenck, H. J. (1965).Smoking, Health and Personality, Weidenfeld and Nicholson, London.

  28. Eysenck, H. J., and Broadhurst, P. L. (1964). Experiments with animals: Introduction. In Eysenck, H. J. (ed.),Experiments in Motivation, Pergamon, Oxford, pp. 285–291.

  29. Ferraro, D. P., and York, K. M. (1968). Punishment effects in rats selectively bred for emotional elimination.Psychon. Sci. 10:177–178.

  30. Festing, M., and Staats, J. (1973). Standardized nomenclature for inbred strains of rats: Fourth listing.Transplantation 16:221–245.

  31. Feuer, G. (1963a). Adrenal cortical activity and stress response in rats selectively bred for differences in behaviour.J. Physiol 169:43P-44P.

  32. Feuer, G. (1963b). Influence of thyroid and adrenocorticotrophic hormones and of genetic factors on cholesterol metabolism in the rat. In Grant, J. K. (ed.),The Control of Lipid Metabolism, Academic Press, London, pp. 99–100.

  33. Feuer, G. (1969). Difference in emotional behaviour and in function of the endocrine system in genetically-different strains of albino rats. In Bajusz, E. (ed.),Physiology and Pathology of Adaptation Mechanisms, Pergamon, Oxford, pp. 214–233.

  34. Fulker, D. W. (1970). Maternal buffering of rodent genotype responses to stress: A complex genotype-environment interaction.Behav. Genet. 1:119–124.

  35. Fulker, D. W. (1972). Personal communication.

  36. Fulker, D. W., and Rick, J. T. (1973). Effects of preweaning stimulation on the GABA production in rat cortex.Develop. Psychobiol. 6:349–356.

  37. Garg, M. (1969a). The effects of some central nervous system stimulant and depressant drugs on rearing activity in rats.Psychopharmacologia 14:150–156.

  38. Garg, M. (1969b). Variations in effects of nicotine in four strains of rats.Psychopharmacologia 14:432–438.

  39. Garg, M. (1970). Combined effect of drug and drive on the consolidation process.Psychopharmacologia 18:172–179.

  40. Garg, M., and Holland, H. C. (1967). Consolidation and maze learning: A comparison of several post-trial treatments.Life Sci. 6:1987–1997.

  41. Garg, M., and Holland, H. C. (1968a). Consolidation and maze learning: A further study of post-trial injections of a stimulant drug (nicotine).Int. J. Neuropharmacol. 7:55–59.

  42. Garg, M., and Holland, H. C. (1968b). Consolidation and maze learning: The effects of posttrial injections of a depressant drug (pentobarbital sodium).Psychopharmacologia 12:127–132.

  43. Garg, M., and Holland, H. C. (1968c). Consolidation and maze learning: The effects of posttrial injections of a stimulant drug (picrotoxin).Psychopharmacologia 12:96–103.

  44. Garg, M., and Holland, H. C. (1969). Consolidation and maze learning: A study of some strain/drug interactions.Psychopharmacologia 14:426–431.

  45. Gray, J. A. (1965). A time-sample study of the components of general activity in selected strains of rats.Can. J. Psychol. 19:74–82.

  46. Gray, J. A. (1971).The Psychology of Fear and Stress, Weidenfeld and Nicholson, London.

  47. Gray, J. A. (1974). Personal communication.

  48. Gray, J. A., and Levine, S. (1964). The effect of induced oestrus on emotional behaviour in selected strains of rats.Nature 201:1198–1200.

  49. Gray, J. A., Levine, S., and Broadhurst, P. L. (1965). Gonadal hormone injections in infancy and adult emotional behaviour.Anim. Behav. 13:33–45.

  50. Gregory, K. (1967a). A note on strain differences in exploratory activity (rearing).Life Sci. 6:1253–1256.

  51. Gregory, K. (1967b). Stress and strain—The suppression of activity in two strains of rats after exposure to electric shock.Act. Nerv. Super. 9:140–144.

  52. Gregory, K. (1968). The action of the drug prenylamine (Segontin) on exploratory activity in strains of rats selectively bred for differences in emotionality.Psychopharmacologia 13:29–34.

  53. Gregory, K., and Liebelt, E. (1967). An examination of sex and strain differences in the rearing response to a novel environment.Act. Nerv. Supper. 9:137–139.

  54. Gregory, K., Gupta, B. D., and Holland, H. C. (1967). The effects of drugs on activity in two strains of rats selectively bred for high and low emotionality.Life Sci. 6:981–988.

  55. Groves, J. R. (1971). Some determinants of individual differences in rats: Behavioural arousal and learning. Unpublished doctoral dissertation, University of London.

  56. Gupta, B. C., and Gregory, K. (1967). The effects of drugs and their combinations on the rearing response in two strains of rats.Psychopharmacologia 11:365–371.

  57. Gupta, B. D., and Holland, H. C. (1969a). An examination of the effects of stimulant and depressant drugs on escape/avoidance conditioning in strains of rats selectively bred for emotionality/non-emotionality.Psychopharmacologia 14:95–105.

  58. Gupta, B. D., and Holland, H. C. (1969b). An examination of the effects of stimulant and depressant drugs on escape/avoidance conditioning in strains of rats selectively bred for emotionality/non-emotionality: Intertrial activity.Int. J. Neuropharmacol. 8:227–234.

  59. Gupta, B. D., and Holland, H. C. (1972a). An examination of the effects of stimulant and depressant drugs on escape/avoidance conditioning in strains of rats selectively bred for emotionality/non-emotionality: A multivariate analysis of the effects of drugs on conditioned avoidance responses and intertrial activity.Neuropharmacology 11:23–30.

  60. Gupta, B. D., and Holland, H. C. (1972b). Emotion as a determinant of the effects of drugs and their combination on different components of behaviour in rats.Neuropharmacology 11:31–38.

  61. Hall, C. S. (1938). The inheritance of emotionality.Sigma Xi Quart. 26:17–27, 37. Also in Martin, W. F., and Stendler, C. B. (eds.) (1954).Readings in Child Development, Harcourt Brace, New York, pp. 58–68.

  62. Harrington, G. M. (1971a). Strain differences among rats initiating exploration of different environments.Psychon. Sci. 23:348–349.

  63. Harrington, G. M. (1971b). Strain differences in rotating wheel activity of the rat.Psychon. Sci. 27:363–364.

  64. Harrington, G. M. (1972). Strain differences in open-field behavior of the rat.Psychon. Sci. 27:51–53.

  65. Harrington, G. M., and Hanlon, J. R. (1966). Heart rate, defecation and genetic differences in rats.Psychon. Sci. 6:425–426.

  66. Holland, H. C. (1974). Temperament and tumour: A note on the growth index in two strains of rats following the implantation of a carcinogenic agent.Act. Nerv. Super. 16:17–19.

  67. Holland, H. C., and Gupta, B. D. (1966). The effects of different doses of methylpentynol on escape/avoidance conditioning in two strains of rats selectively bred for high and low “emotionality.”.Psychopharmacologia 9:419–425.

  68. Holland, H. C., and Gupta, B. D. (1967). Effects of drugs on the rearing response in emotionally reactive and non-reactive rats.Act. Nerv. Super. 9:134–136.

  69. Imada, H. (1970). Amount of open-field defecation, home cage defecation and food and water intake in Maudsley reactive and non-reactive strains of rats.Ann. Anim. Psychol. 20:1–6.

  70. Imada, H. (1972). Emotional reactivity and conditionability in four strains of rats.J. Comp. Physiol. Psychol. 79:474–480.

  71. Joffe, J. M. (1964). Avoidance learning and failure to learn in two strains of rats selectively bred for emotionality.Psychon. Sci. 1:185–186.

  72. Joffe, J. M. (1965a). Effect of foster-mothers' strain and pre-natal experience on adult behaviour in rats.Nature 208:815–816.

  73. Joffe, J. M. (1965b). Genotype and prenatal and premating stress interact to affect adult behavior in rats.Science 150:1844–1845.

  74. Joffe, J. M. (1969).Prenatal Determinants of Behaviour, Pergamon Press, Oxford.

  75. Katz, D. M. (1973). Personal communication. In Kumar, R., and Stolerman, I. P., Morphine dependent behaviour in rats: Some clinical implications.Psychol. Med. 3:225–237.

  76. Keehn, J. D. (1972a). Schedule-induced drinking and biting by the Maudsley strains of rats. Unpublished manuscript.

  77. Keehn, J. D. (1972b). Effects of trihexyphenidyl on schedule-induced alcohol drinking by rats.Psychon. Sci. 29:20–22.

  78. Keehn, J. D. (1974). Agresión dependiente de programas. In Bandura, A., and Ribes, E. (eds.),Modificación de Conducta: Análisis Experimental de la Delincuencia y la Agresión Social, Trillas, México.

  79. Lonowski, D. J., Levitt, R. A., and Larson, S. D. (1974). Mouse killing and carrying by Maudsley and Long-Evans strain rats. Unpublished manuscript.

  80. Martin, L. K., and Powell, B. J. (1970). Role of drug effects and UCS intensity in avoidance acquisition of the Maudsley MNR and MR strains.Psychon. Sci. 18:44–45.

  81. Mikhail, A. A. (1969). Genetic predisposition to stomach ulceration in emotionally reactive strains of rats.Psychon. Sci. 15:245–247.

  82. Mikhail, A. A. (1972). The effects of conditioned anxiety on the recovery from experimental ulceration.J. Psychosom. Res. 16:115–122.

  83. Mikhail, A. A., and Broadhurst, P. L. (1965). Stomach ulceration and emotionality in selected strains of rats.J. Psychosom. Res. 8:477–479.

  84. Powell, B. J. (1970). Alcohol effects on reversal learning in the Maudsley MR and MNR strains.Proc. 78th Ann. Convention APA, pp. 825–826.

  85. Powell, B. J., and Hopper, D. J. (1971). Effect of strain differences andd-amphetamine sulfate on avoidance performance.Psychon. Sci. 22:167–168.

  86. Powell, B. J., and North-Jones, M. (1974). Effects of early handling on avoidance performance of Maudsley MR and MNR strains.Develop. Psychobiol. 7:145–148.

  87. Rick, J. T., and Fulker, D. W. (1972). Some biochemical correlates of inherited behavioural differences. In Bradley, P. B., and Brimblecombe, R. W. (eds.),Biochemical and Pharmacological Mechanisms Underlying Behaviour, Progress in Brain Research, Vol. 36, Elsevier, Amsterdam, pp. 105–113.

  88. Rick, J. T., Huggins, A. K., and Kerkut, G. A. (1967). The comparative production of γ-amino butyric acid in the Maudsley reactive and non-reactive strains of rat.Comp. Biochem. Physiol. 20:1009–1012.

  89. Rick, J. T., Tunnicliff, G., Kerkut, G. A., Fulker, D. W., Wilcock, J. and Broadhurst, P. L. (1971). GABA production in brain cortex related to activity and avoidance in eight strains of rat.Brain Res.,32:234–238.

  90. Robinson, R. (1965).Genetics of the Norway Rat, Pergamon, Oxford.

  91. Satinder, K. P. (1971). Genotype-dependent effects ofd-amphetamine sulphate and caffeine on escape-avoidance behavior of rats.J. Comp. Physiol. Psychol. 76:359–364.

  92. Satinder, K. P. (1972a). Behavior-genetic-dependent self-selection of alcohol in rats.J. Comp. Physiol. Psychol. 80:422–434.

  93. Satinder, K. P. (1972b). Effects of intertrial crossing punishment andd-amphetamine sulfate on avoidance and activity in selectively bred rat strains.Psychon. Sci. 29:291–293.

  94. Satinder, K. P. (1974a). Genetic analysis of chronic alcohol intake in rats: Behavioral model. Unpublished manuscript.

  95. Satinder, K. P. (1974b). Genetic analysis of oral self-administration of morphine in rats. Unpublished manuscript.

  96. Satinder, K. P. (1974c). Genotype-specific reactions of rats to a cat. Unpublished manuscript.

  97. Savage, R. D. (1965). An analysis of learning curves: Inherited strain and environmental determinants.Behav. Res. Ther. 2:281–283.

  98. Sudak, H. S., and Maas, J. W. (1964). Behavioral-neurochemical correlation in reactive and nonreactive strains of rats.Science 146:418–420.

  99. Wampler, R. S. (1964). Summation of water aversion and hunger drives in two strains of rats selectively bred for emotionality. Paper presented at meeting of Midwestern Psychological Association.

  100. Weldon, E. (1967). An analogue of extraversion as a determinant of individual differences in behaviour in the rat.Brit. J. Psychol. 58:253–259.

  101. Weldon, E. (1968a). Stimulus or stimulation: Relevant cues in a learning situation involving differences in light reinforcement.Psychon. Sci. 10:239–240.

  102. Weldon, E. (1968b). To see, or not to see: Rearing activity as a function of changes in the visual field.Psychon. Sci.,12:83–84.

  103. Weldon, E. (1969). Rearing activity as a measure of sensory reinforcement.Bull. Brit. Psychol. Soc. 22:148 (abst.).

  104. Wilcock, J. (1966). The role of interfering and facilitatory responses in avoidance conditioning in rats.Bull. Brit. Psychol. Soc. 19:A28 (abst.).

  105. Wilcock, J. (1968). Strain differences in response to shock in rats selectively bred for emotional elimination.Anim. Behav. 16:294–297.

  106. Wilcock, J., and Broadhurst, P. L. (1967). Strain differences in emotionality: Open-field and conditioned avoidance behavior in the rat.J. Comp. Physiol. Psychol. 63:335–338.

  107. Wraight, K. B., Weldon, E., Gupta, B. D., and Holland, H. C. (1967). The effects of post-trial injections of nicetine on the learning of an underwater discrimination task by rats.Anim. Behav. 15:287–290.

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This paper is dedicated on his sixty-fifth birthday to Calvin S. Hall, one of the pioneers of psychogenetics on whose foundations the next generation of workers has, typically, built.

The preparation of this paper was supported in part by a grant from the (British) Medical Research Council to Professor J. L. Jinks and the writer, and in part by the latter's Resident Fellowship at NIAS (Netherlands Institute for Advanced Study) for 1973–1974.

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Broadhurst, P.L. The Maudsley Reactive and Nonreactive strains of rats: A survey. Behav Genet 5, 299–319 (1975). https://doi.org/10.1007/BF01073201

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Key Words

  • rat
  • selective breeding
  • emotionality
  • Maudsley strains