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The value of the gelatin infusion test in the diagnosis of pancreatic exocrine insufficiency in patients with Billroth II anastomoses

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Abstract

Infusion of a test solution of gelatin into the proximal jejunum of 5 patients with Billroth II anastomoses with no suspected pancreatic disease produced a mean hydrolysis of 46.2%±4.9 SD of the infused gelatin to dialyzable peptides. In 3 patients with Billroth II anastomoses and chronic pancreatitis, the mean hydrolysis was 16%±2.6 SD. In 5 normal subjects and 7 patients with chronic pancreatitis and no prior surgery, the mean intraduodenal gelatin hydrolysis was 72.4%±9.1 SD and 9.0%±3.6 SD, respectively. These preliminary studies indicate that the gelatin infusion test may be of value in assessing pancreatic function in patients with Billroth II anastomoses in whom a secretin test cannot be performed.

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References

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    Cerda JJ, Brooks FP, Prockop DJ: Intraduodenal hydrolysis of gelatin as a measure of protein digestion in normal subjects and in patients with malabsorption syndromes. Gastroenterology 54:358–365, 1968

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Author information

Correspondence to James J. Cerda MD.

Additional information

This study was supported in part by Training Grant TI-AM-5462-04 from the National Institutes of Health and a Clinical Investigator Award, Veterans Administration, Washington, DC.

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Toskes, P.P., Cerda, J.J. The value of the gelatin infusion test in the diagnosis of pancreatic exocrine insufficiency in patients with Billroth II anastomoses. Digest Dis Sci 18, 147–150 (1973). https://doi.org/10.1007/BF01073160

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Keywords

  • Public Health
  • Peptide
  • Hydrolysis
  • Pancreatitis
  • Gelatin