The American Journal of Digestive Diseases

, Volume 18, Issue 2, pp 111–119 | Cite as

Chronic active hepatitis and Graves' disease

  • W. Grant Thompson
  • Ian R. Hart
Original Articles


Two young females who had chronic active hepatitis associated with Graves' disease are reported. Both patients had high circulating levels of immunoglobulin G and 1 had a monoclonal gammopathy which disappeared with steroid therapy. The other patient had exophthalmos and high circulating levels of long acting thyroid stimulator (LATS) which were paralleled by very high antibody titers to respiratory syncytial virus, herpes simplex, and echovirus 9. Both patients showed positive smooth muscle antibody and negative Australia antigen. In 1 case LATS and smooth muscle antibodies were found in the pleural fluid. Both patients had a wide variety of abnormal antibodies.


Steroid Herpes Simplex Antibody Titer Respiratory Syncytial Virus Steroid Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Medical Department - Harper & Row, Publishers, Inc. 1973

Authors and Affiliations

  • W. Grant Thompson
    • 1
  • Ian R. Hart
    • 1
  1. 1.Gastrointestinal Unit and Department of Metabolism, Division of MedicineOttawa Civic Hospital, University of OttawaOttawaCanada

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