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The effect of phenobarbital on biliary lipid metabolism and hepatic microsomal drug metabolism in patients with cholesterol cholelithiasis

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Six patients with cholesterol cholelithiasis were studied before and after 3 weeks treatment with phenobarbital, 120 mg/day. The kinetics of cholic and chenodeoxycholic acid and biliary lipid composition were not significantly affected by phenobarbital treatment although hepatic mixed-function oxidase was stimulated by the treatment as shown by increased breath output of14CO 2 after administration of [14C]aminopyrine. It is concluded that treatment with phenobarbital is unlikely to be effective therapy for patients with cholesterol cholelithiasis.

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Correspondence to Dr. Gershon W. Hepner MD.

Additional information

This work was supported in part by grant AM 17303 from the National Institutes of Health.

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Hepner, G.W. The effect of phenobarbital on biliary lipid metabolism and hepatic microsomal drug metabolism in patients with cholesterol cholelithiasis. Digest Dis Sci 21, 370–375 (1976).

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  • Public Health
  • Lipid
  • Cholesterol
  • Lipid Metabolism
  • Drug Metabolism