The American Journal of Digestive Diseases

, Volume 23, Issue 7, pp 609–617 | Cite as

Obstructive jaundice caused by hepatocellular carcinoma report of three cases

  • A. Afroudakis
  • S. M. Bhuta
  • K. A. Ranganath
  • N. Kaplowitz
Original Articles


A cholestatic syndrome secondary to extrahepatic biliary obstruction as the presenting manifestation of hepatocellular caroinoma is aescribed in three cases. The mechanism is related to the invasion of intrahepatic bile ducts by the carcinoma. The consequent mechanical obstruction is due to either a continuous distally growing tumor cast of the biliary tree, distal migration of a necrotic tumor fragment, or hemobilia. In the cirrhotic patient with a predisposition for the deyelopment of liver cancer, the physician should be aware of the presentation with obstructive jaundice as a mechanical complication of hepatocellular carcinoma


Public Health Carcinoma Migration Bile Duct Hepatocellular Carcinoma 
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  1. 1.
    Becker FF: Hepatoma-nature's nodel tumor, Am J Pathol 74:179–198, 1974Google Scholar
  2. 2.
    Okuda K: Clinical aspects of hepatocellular carcinoma analysis of 134 cases. Hepatocellular Carcinoma. K. Okud, RL Peters (eds). New York, Wiley Medical Publication. 1976. pp. 387–436Google Scholar
  3. 3.
    Ihde DC, Sherlock P, Winawer SJ: Clinical manifestations of hepatoma: A review of 6 years experience at a cancerhospital. Am J Med 56:83–91, 1974Google Scholar
  4. 4.
    Dickinson SJ, Santulli TV: Obstruction of common bile duct by hepatoma. Surgery 52:800–802, 1962Google Scholar
  5. 5.
    Waldron RL, Kenney G, Sorger K: Liver-cell carcinoma presenting as bile-duct tumor. Br J Radiol 46:195–197, 1973Google Scholar
  6. 6.
    Kuroyanagi Y, Sawada M, Hidemura R, et al: Common bile duct obstruction by hepatoma. Am J Surg 133:233–235, 1977Google Scholar
  7. 7.
    Gerson CD, Schinella RA: Hepatoma presenting as extrahepatic biliary obstruction. Am J Dig Dis 14:42–47, 1969Google Scholar
  8. 8.
    Wind G, Futtrman S: Obstructive jaundice secondary to hepatoma. Am J Gastroenterol 67:80–83, 1977Google Scholar
  9. 9.
    Mallory TB: Hepatoma with invasion of cystic duct and metastasis 3rd lumbar vertebra. Mass Gen Hospital Case 33441, N Engl J Med 237:673–676, 1947Google Scholar
  10. 10.
    Rudstrom P: Hemobilia in malignant tumors of the liver, Acta Chir Scand 101:243–246, 1951Google Scholar
  11. 11.
    Johns WA, Zimmerman A: Biliary obstruction due to hemobilia caused by liver cell carcinoma. Ann Surg 153:706–710, 1961Google Scholar
  12. 12.
    Brand SN, Brandt LJ, Sprayregan S, et al: Extrahepatic biliary obstruction secondary to a hepatoma-containing blood clot in the common bile duct. Am J Dig Dis 21:905–909, 1976Google Scholar
  13. 13.
    Conn HO, Redeker AG, Zimmon DS: PTC versus ERC-an editor's dream. Gastroenterology 71:520–521, 1976Google Scholar
  14. 14.
    Lee FI: Cirrhosis and hepatoma in alcoholics. Gut 7:77–85, 1966Google Scholar
  15. 15.
    Shikata T: Primary liver earcinoma and liver cirrhosis. Hepatocellular Carcinoma. K Okuda, RL Peters (eds). New York, Wiley Medical Publication, 1976, pp 53–71Google Scholar
  16. 16.
    Reynolds TB: Diagnostic methods for hepatocellular carcinoma. Hepatocellular Carcinoma. K Okuda, RL Peters (eds). New York, Wiley Medical Publication, 1976, pp 437–448Google Scholar

Copyright information

© Digestive Disease Systems, Inc 1978

Authors and Affiliations

  • A. Afroudakis
    • 1
  • S. M. Bhuta
    • 1
  • K. A. Ranganath
    • 1
  • N. Kaplowitz
    • 1
  1. 1.Medical, Pathology and Research ServicesVA Wadsworth Hospital Center and UCLA School of MedicineLos Angeles

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