The American Journal of Digestive Diseases

, Volume 23, Issue 10, pp 887–892 | Cite as

Malignant lymphoproliferative disorders in chronic liver disease

Report of four cases and review of the literature
  • Jacob Naparstek
  • Marcel Eliakim
Original Articles


Four patients who manifested an association between chronic liver disease and lymphoma are reported. Three of them had nonalcoholic cirrhosis and one had chronic cholangitis. Non-Hodgkin's lymphoma developed long after the presence of liver disease had been established in three of the patients. The fourth patient died of hepatic coma and Hodgkin's disease was discovered incidentally at autopsy. Drugs could not be incriminated in the development of either cirrhosis or lymphoma in any of the patients. A review of the literature is presented, and the view that the association between chronic liver disease and lymphoma is not coincidental is supported.


Public Health Lymphoma Liver Disease Chronic Liver Chronic Liver Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Heimann R: Cirrhosis and lymphoproliferative disorders. Lancet 2:101, 1971Google Scholar
  2. 2.
    Heimann R: Cirrhoses et lymphopathies malignes. Acta Gastro-Enterol Belg 34:663–675, 1971Google Scholar
  3. 3.
    Heimann R, Cirrhosis and lymphoproliferative disorders. Lancet 2:705, 1971Google Scholar
  4. 4.
    Heimann R, Ray MB, Desmet VJ: HBsAg, chronic lymphoproliferative disorders and cirrhosis of liver. J Clin Pathol 30:817–821, 1977Google Scholar
  5. 5.
    Viteri A, Vernace SJ, Schaffner F: Extrahepatic malignancy in chronic liver disease: Report of six cases. Gastroenterology 71:1075–1078, 1976Google Scholar
  6. 6.
    Weinberg T: Observations on the occurrence of varices of the esophagus in routine autopsy material. Am J Clin Pathol 19:554–557, 1949Google Scholar
  7. 7.
    Levitan R, Diamond HD, Craver LF: Esophageal varices in Hodgkin's disease involving the liver. Am J Med 27:137–143, 1959Google Scholar
  8. 8.
    Rosenberg SA, Diamond HD, Craver LF: Lymphosarcoma: The effect of therapy and survival in 1,269 patients in a review of 30 years experience. Ann Intern Med 53:877–897, 1960Google Scholar
  9. 9.
    Kurtz RC, Sherlock P, Winawer SJ: Esophageal varices—development secondary to primary and metastatic liver tumors. Arch Intern Med 134:50–51, 1974Google Scholar
  10. 10.
    Slavin S, Zlotnick A, Levij IC, Eliakim M: Clinical implications of monoclonal gammopathy in chronic liver disease. Am J Dig Dis 19:223–234, 1974Google Scholar
  11. 11.
    Dupuy MR: Cirrhose ethylique compensee purpura inflammatoire et cryoglobulinemie—lymphosarcome. Arch Fr Mal App Dig 56:961–964, 1967Google Scholar
  12. 12.
    Pirotte JH: Development of Hodgkin's disease in the course of active chronic hepatitis treated by immunosuppressive drugs. Am J Gastroenterol 62:230–239, 1974Google Scholar
  13. 13.
    Levitan R, Diamond HO, Craver LF: The liver in Hodgkin's disease. Gut 2:60–71, 1961Google Scholar
  14. 14.
    Amronim GD, Delenian RM, Shanbrom E: Liver damage after chemotherapy for leukemia and lymphoma. Gastroenterology 42:401–410, 1962Google Scholar
  15. 15.
    Bouroncle BA, Old JW, Vazques AG: Pathogenesis of jaundice in Hodgkin's disease. Arch Intern Med 110:872–883, 1962Google Scholar
  16. 16.
    Nowoslawski A, Brzosko WS, Madalinski K, Krawczynski: Cellular localization of Australia antigen in the liver of patients with lymphoproliferative disorders. Lancet 1:494–498, 1970Google Scholar
  17. 17.
    Najman A, Gerbal A, Ropars C, Homberg JC, Dukamel G, Andre R: Variations provoquees par une maladie hepatique du taux des immunoglobulines seriques au cours des leucemies lymphoides chroniques. Nouv Rev Fr Hematol 11:365–372, 1971Google Scholar
  18. 18.
    Prutz H, Bjorneboe M, Christoffersen H, Poulsen H, Ørskov F: Correlation between hepatic morphology and immunoglobulins and antibodies toE. coli in cirrhosis. Gut 18:28–32, 1977Google Scholar
  19. 19.
    Bjorneboe M, Prytz H, Orskov F: Antibodies to intestinal microbes in serum of patients with cirrhosis of the liver. Lancet 1:58–60, 1972Google Scholar
  20. 20.
    Jarrold T, Vilter RW: Hematological observations in patients with chronic hepatic insufficiency. Sternal bone marrow morphology and bone marrow plasmacytosis. J Clin Invest 28:286–292, 1949Google Scholar
  21. 21.
    Osserman EE, Takatsuki K: Considerations regarding the pathogenesis of the plasmocytic dyscrasias. Ser Haematol 4:28–49, 1965Google Scholar
  22. 22.
    Zawadzki ZA, Edwards GA: Dysimmunoglobulinemia associated with hepatobiliary disorders. Am J Med 48:196–202, 1970Google Scholar
  23. 23.
    Eliakim M, Zlotnick A, Slavin S: Gammopathy in liver disease. Progress in Liver Diseases, Vol. 4 H Popper, F Schaffner (eds). New York, Grune & Stratton, 1972, pp 403–417Google Scholar
  24. 24.
    Mackay IR, Eriksen N, Motulsky AG, Volwiler W: Cryo-and macroglobulinemia. Electrophoresis, ultracentrifugal and clinical studies. Am J Med 20:564–578, 1956Google Scholar
  25. 25.
    Metcalf D: Reticular tumours in mice subjected to prolonged stimulation. Br J Cancer 15:769–779, 1961Google Scholar
  26. 26.
    Mellors RC: Autoimmune diseases in NZB/B1 mice II. Autoimmunity and malignant lymphoma. Blood 27:435–448, 1966Google Scholar
  27. 27.
    Talal N: Autoimmunity and lymphoid malignancy in New Zealand Black mice. Progress in Clinical Immunology, Vol. 2. RS Schwartz (ed). New York, Grune & Stratton, 1974, pp 101–120Google Scholar
  28. 28.
    Rappaport H, Moran EM: Angioimmunoblastic (immunoblastic) lymphadenopathy. N Engl J Med 292:42–43, 1975Google Scholar
  29. 29.
    Lukes RJ, Tindle BH: Immunoblastic lymphadenopathy—a hyperimmune entity resembling Hodgkin's disease. N Engl J Med 292:1–8, 1975Google Scholar
  30. 30.
    Talal N, Bunim JJ: The development of malignant lymphoma in the course of Sjogren syndrome. Am J Med 36:529–540, 1964Google Scholar
  31. 31.
    Pinkus GS, Dikker A: Benign lymphoepithelial lesion of the parotid gland associated with reticulum cell sarcoma. Cancer 25:121–127, 1970Google Scholar
  32. 32.
    Hornbaker JH, Foster EA, Williams GS, Davis JS: Sjogren syndrome and nodular reticulum cell sarcoma. Arch Intern Med 118:449–452, 1966Google Scholar
  33. 33.
    Miller DG: The association of immune disease and malignant lymphoma. Ann Intern Med 66:507–521, 1967Google Scholar
  34. 34.
    Cammurata RJ, Radnan GP, Jenssen WN: Systemic rheumatic disease and malignant lymphoma. Arch Intern Med 111:330–337, 1963Google Scholar
  35. 35.
    Smith CK, Cassidy JT, Bole GG: Dysgammaglobulinemia, systemic lupus erythematosus and lymphoma. Am J Med 48:113–119, 1970Google Scholar
  36. 36.
    Canoso JJ, Cohen AS: Malignancy in a series of 70 patients with SLE. Arthritis Rheum 17:383–390, 1974Google Scholar
  37. 37.
    Harries OD, Cooke WT, Thompson H, Waterhouse JAH: Malignancy in adult coeliac disease and idiopathic steatorrhoea. Am J Med 42:899–912, 1967Google Scholar
  38. 38.
    Rappaport H, Ramot B, Hulu N, Park JK: The pathology of so-called Mediterranean abdominal lymphoma with malabsorption. Cancer 29:1502–1511, 1972Google Scholar
  39. 39.
    Shouval D, Penchas S, Sandler SG, Mansour D, Eliakim M: Chronic active hepatitis in Jerusalem. Comparison between HBsAg-positive cases. Am J Gastroenterol 69:70–80, 1978Google Scholar
  40. 40.
    Sutnick AI, Millman I, London WT, Blumberg BS: The role of Australia antigen in viral hepatitis and other diseases. Annu Rev Med 23:161–176, 1972Google Scholar
  41. 41.
    Wands JR, Chura CM, Roll FI, Maddrey WC: Serial studies of hepatitis-associated antigen and antibody in patients receiving antitumor chemotherapy for myeloproliferative and lymphoproliferative disorders. Gastroenterology 68:105–112, 1975Google Scholar
  42. 42.
    Grange MJ, Erlinger S, Teillet F, Schlegel N, Barge J, Degott C: A possible relationship to treatment between hepatitis-associated antigen and chronic persistent hepatitis in Hodgkin's disease. Gut 14:433–437, 1973Google Scholar
  43. 43.
    Hammond IP, Brettschneider L, Starzl TE: Malignant lymphoma in transplantation patients. Transplant Proc 1:106–112, 1969Google Scholar
  44. 44.
    Fahey JL: Cancer in the immunosuppressed patient. Ann Intern Med 75:310–312, 1971Google Scholar

Copyright information

© Digestive Disease Systems, Inc. 1978

Authors and Affiliations

  • Jacob Naparstek
    • 1
  • Marcel Eliakim
    • 1
  1. 1.Department of Medicine AHadassah University HospitalJerusalemIsrael

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