The effect of synthetic motilin on contractile activity in the lower esophageal sphincter (LES) and the stomach has been studied in 5 healthy dogs by means of chronically implanted strain gage force transducers. Motilin produced strong contractions in the LES and the stomach simultaneously after intravenous doses ranging from 0.3 to 2.7 μg/kg hr, which were similar to the naturally occurring interdigestive contractions in the LES and the stomach. However, these contractions could be induced only in the interdigestive state; infusion of motilin into dogs in the digestive state brought about no significant effect on either the LES or the stomach. Motilin-induced contractions in the LES and the stomach were instantly abolished by ingestion of food. It is considered that the contractions induced by motilin are identical with the naturally occurring interdigestive contractions in the LES and these contractions are the most orad component of the interdigestive cyclic recurring caudad-moving bands of strong contractions in the dogs.
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Itoh Z, Honda R, Aizawa I, Takeuchi S, Hiwatashi K, Couch EF: Interdigestive motor activity of the lower esophageal sphincter in conscious dogs. Am J Dig Dis (in press)
Itoh Z, Aizawa I, Takeuchi S, Couch EF: Hunger contractions and motilin. Proc. of the 5th International Symposium on Gastrointestinal Motility. G Vantrappen (ed). Herentals, Belgium, Typoff-Press, 1975, pp 48–55
Itoh Z, Honda R, Hiwatashi K, Takeuchi S, Aizawa I, Takayanagi R, Couch EF: Motilin-induced mechanical activity in the canine alimentary tract. Scand J Gastroenterol 11 (Suppl 39):93–110, 1976
Brown JC, Cook MA, Dryburgh JR: A gastric motor-activity stimulating polypeptide: Final purification, amino acid composition, and C-terminal residues. Gastroenterology 62:401–404, 1972
Brown JC, Cook MA, Dryburgh JR: Motilin, a gastric motor activity stimulating polypeptide: The complete amino acid sequence. Can J Biochem 51:533–537, 1973
Itoh Z, Carlton N, Lucien HW, Schally AV: Long-term plastic tubing implantation into the external jugular vein for injection or infusion in the dog. Surgery 66:768–770, 1969
Bass P, Wiley JN: Contractile force transducer for recording muscle activity in unanesthetized animals. J Appl Physiol 32:567–670, 1972
Itoh Z, Aizawa I, Takeuchi S, Takayanagi R: Diurnal changes in gastric motor activity in conscious dogs. Am J Dig Dis 22:117–124, 1977
Shimizu F, Imagawa K, Mihara S, Yanaihara N: Synthesis of porcine motilin by fragment condensation using three protected peptide fragments. Bull Chem Soc Jpn 49:3594–3596, 1976
Jennewein HM, Bauer R, Hummelt H, Lepsin G, Siewert R: Motilin effects on gastrointestinal motility and lower esophageal sphincter (LES) pressure in dogs. Scand J Gastroenterol 11 (Suppl 39):63–65, 1976
Meissner AJ, Bowes KL, Zwick R, Daniel EE: Effect of motilin on the lower esophageal sphincter. Gut 17:925–932, 1976
Lux G, Rösch W, Domschke S, Domschke W, Wünsch E, Jaeger E, Demling L: Intravenous 13-Nle-motilin increases the human lower esophageal sphincter pressure. Scand J Gastroenterol 11 (Suppl 39):75–79, 1976
Domschke W, Lux G, Mitznegg P, Rösch W, Domschke S, Bloom SR, Wünsch E, Demling L: Relationship of plasma motilin response to lower esophageal pressure in man. Scand J Gastroenterol 11 (Suppl 39):81–84, 1976
Hellemans J, Vantrappen G, Bloom SR: Endogenous motilin and the LES pressure. Scand J Gastroenterol 11 (Suppl 39): 67–73, 1976
Eckardt V, Grace ND: Lower esophageal sphincter pressure and serum motilin levels. Am J Dig Dis 21:1008–1011, 1976
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Itoh, Z., Aizawa, I., Honda, R. et al. Control of lower-esophageal-sphincter contractile activity by motilin in conscious dogs. Digest Dis Sci 23, 341–345 (1978). https://doi.org/10.1007/BF01072418
- Public Health
- Strain Gage
- Lower Esophageal Sphincter
- Intravenous Dose
- Contractile Activity