Cell turnover and loss and the gastric mucosal barrier
Decreased turnover and increased loss of gastric epithelial cells cause disruption of the gastric mucosal barrier. Stress, cortisone, ACTH, and uremia reduce the production rate of gastric epithelial cells. Aspirin, alcohol, phenylbutazone, chili powder, and tobacco powder cause acute loss of epithelial cells. In atrophic gastritis there is a high turnover which may be partly responsible for its resistance to the effect of aspirin. Any situation where there is increased cell loss and/or decreased cell production will lead to disequilibrium, disruption of the gastric mucosal barrier, and clinically significant gastric lesions such as gastric erosions and hemorrhagic erosive gastritis.
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