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Examination of stomach wall Mg2+−Na+−K+-dependent ATPase, ATP, and ADP in pylorus-ligated rats

Abstract

Stomach wall Mg2+−Na+−K+-dependent ATPase, ATP, and ADP were studied in rats, at 4, 7, 17, and 24 hr after pylorus ligation, in order to relate H+ secretion and ulcer development. It was observed, in both parts of forestomach and corpus + antrum, that the stomach wall Mg2+−Na+−K+-dependent ATPase significantly increased at 4 and 7 hr, while it significantly decreased at 24 hr, after pylorus ligation. Contrary to this, stomach-wall ATP decreased at 4 hr, relatively increased at 7 hr, thereafter significantly decreased in forestomach and corpus + antrum. Ouabain inhibited the H+ secretion, ulcer development, and stomach wall Mg2+−Na+−K+-dependent ATPase activity. The possible causal interrelationships between the examined parameters are studied.

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Correspondence to Dr. G. Mózsik PhD.

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Mózsik, G., Vizi, F. Examination of stomach wall Mg2+−Na+−K+-dependent ATPase, ATP, and ADP in pylorus-ligated rats. Digest Dis Sci 21, 649–654 (1976). https://doi.org/10.1007/BF01071959

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Keywords

  • Public Health
  • ATPase Activity
  • Ouabain
  • Stomach Wall
  • Dependent ATPase