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Carbazochrome salicylate and its role in aspirin-induced gastric irritation in rats


Carbazochrome salicylate (CS) (Adrenosem®, S.E. Messengill Co., Bristol, Tennessee) was tried in aspirin-induced gastric mucosal injury in rats because of the manufacturer's claim that it stops bleeding by its action on capillary permeability. Adrenosem could not stop this injury to rat stomach mucosa; on the contrary it enhanced the aspirin-induced injury significantly (P<0.0005).

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Correspondence to Jagdish C. Mangla MD, FRCP(C), FACP.

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Mangla, J.C., Kim, Y. & Desbaillets, L.G. Carbazochrome salicylate and its role in aspirin-induced gastric irritation in rats. Digest Dis Sci 19, 830–834 (1974). https://doi.org/10.1007/BF01071943

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  • Public Health
  • Permeability
  • Salicylate
  • Mucosal Injury
  • Capillary Permeability