Symptomatic gastroesophageal reflux: Incidence and precipitating factors
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The incidence and precipitating factors associated with symptomatic gastroesophageal reflux were evaluated by a questionnaire in 446 hospitalized and 558 nonhospitalized subjects. Of 385 control subjects 7% experienced heartburn daily, 14% noted heartburn weekly, and 15% experienced it once a month, giving a total of 36% of subjects having heartburn at least monthly. Daily heartburn occurred at a significantly greater (P<0.05) rate for 246 medical inpatients (14%) and for 121 patients seen in outpatient gastroenterological clinic (15%). Pregnant women seen in uncomplicated obstetrical clinic had symptoms of significantly greater (P<0.01) incidence: daily (25%) and at least once monthly (52%). Age, sex, or hospitalization did not significantly affect incidence. Fried foods, “spicy” foods, and alcohol were the most common precipitating factors.
KeywordsPublic Health Alcohol Pregnant Woman Control Subject Gastroesophageal Reflux
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- 1.Castell DO: Changes in lower esophageal sphincter pressure during insulin-induced hypoglycemia. Gastroenterology 61:10–15, 1971Google Scholar
- 2.Cohen S, Lipshutz W: Hormonal regulation of human lower esophageal sphincter strength: Interaction of gastrin and secretin. J Clin Invest 50:449–454, 1971Google Scholar
- 3.Resin H, Stern DH, Sturdevant RA, et al: Effect of the C-terminal octapeptide of cholecystokinin on lower esophageal sphincter pressure in man. Gastroenterology 64:946–949, 1973Google Scholar
- 4.Nebel OT, Castell DO: Lower esophageal sphincter pressure changes after food ingestion. Gastroenterology 63:778–783, 1972Google Scholar
- 5.Hogan WJ, Viegas de Andrade SR, Winship DH: Ethanol-induced acute esophageal motor dysfunction. J Appl Physiol 36:755–760, 1972Google Scholar
- 6.Babka JC, Castell DO: On the genesis of heartburn. The effects of specific foods on the lower esophageal sphincter. Am J Dig Dis 18:391–397, 1973Google Scholar