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Relationship between alcohol dehydrogenase (ADH) activity and behavioral response to environmental alcohol in fiveDrosophila species

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FiveDrosophila species were tested for larval alcohol preference behavior (LAPB) over a range of ethanol concentrations. Four general conclusions came out of the study. (1) Significant interspecific variation in LAPB exists withinDrosophila. (2) The behavioral response is environmentally dependent. (3) Interspecific differences inDrosophila LAPB result from an interplay between two biological factors: alcohol dehydrogenase (ADH)-mediated alcohol catabolism and aldehyde sensitivity. (4) Larval preference for low concentrations of alcohol is independent of relative ADH activity levels.

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This work was supported by NSF Grant DEB-8200965 to John McDonald.

This is paper No. II in a series, studies on the relationship between ADH activity and behavioral response to environmental alcohol inDrosophila.

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Gelfand, L.J., McDonald, J.F. Relationship between alcohol dehydrogenase (ADH) activity and behavioral response to environmental alcohol in fiveDrosophila species. Behav Genet 13, 281–293 (1983). https://doi.org/10.1007/BF01071873

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Key Words

  • drosophila
  • response to ethanol
  • ADH activity