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The American Journal of Digestive Diseases

, Volume 20, Issue 8, pp 703–707 | Cite as

The adverse effect of chocolate on lower esophageal sphincter pressure

  • Lewis E. Wright
  • Donald O. Castell
Original Articles

Abstract

Decreased lower esophageal sphincter (LES) pressure after ingestion of chocolate has been previously noted. We have further evaluated the effect of chocolate on the known ability of gastric alkalinization or bethanechol to increase LES tone. 9 normal subjects were studied using an infused open-tip recording system. Pressure was monitored for a 15-min basal period, and for 60 min after ingestion of 120 ml of chocolate syrup either alone or with the concurrent administration of commercial antacid, oral bethanechol, or subcutaneous bethanechol. After chocolate ingestion, mean basal LES pressure of 14.6±1.1 (±SEM) mm Hg decreased significantly (P<0.01) to 7.9±1.3 mm Hg. An identical LES response occurred when antacid was given with the chocolate dose. Oral bethanechol (25 mg) and chocolate together resulted in lesser decreases in LES pressure. Subcutaneous bethanechol (5 mg) and chocolate produced significant increases (P<0.05) in sphincter pressure, although of lesser magnitude than reported with bethanechol alone. These results indicate that the adverse effect of chocolate on the LES is not reversed by gastric alkalinization and suggest that bethanechol in sufficient dose may overcome chocolate-induced decreases in LES pressure.

Keywords

Public Health Adverse Effect Recording System Lower Esophageal Sphincter Basal Period 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Digestive Disease Systems, Inc. 1975

Authors and Affiliations

  • Lewis E. Wright
    • 1
  • Donald O. Castell
    • 1
  1. 1.The Gastroenterology Branch, Internal Medicine Service And Clinical Investigation ServiceU.S. Naval HospitalPhiladelphia

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