The American Journal of Digestive Diseases

, Volume 20, Issue 3, pp 201–207 | Cite as

Relationship between serum gastrin concentration and lower-esophageal sphincter pressure

  • Wylie J. Dodds
  • Walter J. Hogan
  • William N. Miller
  • Robert F. Barreras
  • Ronald C. Arndorfer
  • John J. Stef
Original Articles

Abstract

Serum gastrin concentration [G] has been proposed as the major factor regulating resting lower-esophageal sphincter pressure (LESP). Available supporting evidence in man, however, is largely circumstantial. The present study directly compares measurements of LESP with concurrent levels of circulating serum gastrin in fasting human subjects. A direct correlation was not shown betwen [G] and resting LESP; rather, a trend existed toward an inverse relationship. The study results indicate that the concentration of serum immunoreactive gastrin is not a major determinant of lower-esophageal sphincter tone in humans.

Keywords

Public Health Human Subject Inverse Relationship Major Determinant Supporting Evidence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Digestive Disease Systems, Inc. 1975

Authors and Affiliations

  • Wylie J. Dodds
    • 1
    • 2
  • Walter J. Hogan
    • 1
    • 2
  • William N. Miller
    • 1
    • 2
  • Robert F. Barreras
    • 1
    • 2
  • Ronald C. Arndorfer
    • 1
    • 2
  • John J. Stef
    • 1
    • 3
  1. 1.Department of Radiology and MedicineThe Medical College of WisconsinMilwaukee
  2. 2.The Department of MedicineUniversity of Wisconsin School of MedicineMadison
  3. 3.Department of RadiologyMilwaukee County Medical ComplexMilwaukee

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