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Mechanism of the exciting action of noradrenalin and adrenalin on the smooth muscle cells of the portal vein

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Abstract

The ionic mechanism of the exciting action of catecholamines — nonadrenalin and adrenalin — on the muscle cells of the portal vein of the rat was investigated by the method of a double "sucrose bridge." To determine the role of various ions in the action of catecholamines, they were removed from Krebs solution and replaced by other ions. In muscle cells kept in sodium-free Krebs solution, just as under normal conditions, the catecholamines induced depolarization of the membrane, an increase in the spontaneous electrical activity, an increase in the excitability, and a decrease in the amplitude of the electrotonic potentials (ETP), i.e., the resistance of the membrane. The exciting action of catecholamines on muscle cells also did not cease after the removal of Ca++ from solution. This action of them was not manifested only in the case when Na+ and Ca++ were removed simultaneously from the surrounding solution. Thus, the exciting action of noradrenalin and adrenalin on muscle cells of the portal vein is due to a decrease in the permeability of the cell membrane for Na+ and Ca++ in a definite quantitative ratio.

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Additional information

A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 2, No. 6, pp. 643–653, November–December, 1970.

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Taranenko, V.M., Shuba, M.F. Mechanism of the exciting action of noradrenalin and adrenalin on the smooth muscle cells of the portal vein. Neurophysiology 2, 490–498 (1970). https://doi.org/10.1007/BF01067762

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Keywords

  • Sucrose
  • Cell Membrane
  • Smooth Muscle
  • Muscle Cell
  • Smooth Muscle Cell