In recent years it has become apparent that the parental origin of genetic material has an impact on gene expression and this effect has become known as genomic imprinting. The evidence for the influence of genomic imprinting on behavior and in the etiology of certain neurobehavioral disorders is discussed. The possibilities for a role for genomic imprinting in the inheritance of behaviors related to alcohol abuse and alcoholism and in the paternal alcohol syndrome are also explored.
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Abel, E. L. (1989). Paternal behavioral mutagenesis.Neurotoxicology 10:335–346.
Abel, E. L., and Lee, J. A. (1988). Paternal alcohol exposure affects offspring behavior but not body or organ weights in mice.Alcohol Clin. Exp. Res. 12:349–355.
Abel, E. L., and Tan, S. E. (1988). Effects of paternal alcohol consumption on pregnancy outcome in rats.Neurotoxicol. Teratol. 10:187–192.
Abel, E. L., Hazlett, L., Berk, R., and Mutchnik, M. (1990). Neuroimmunotoxic effects in offspring of paternal alcohol consumption.Alcohol Immunomod. AIDS 1:47–55.
Allen, N. D., Norris, M. L., and Surani, M. A. (1990). Epigenetic control of transgene expression and imprinting by genotype-specific modifiers.Cell 61:853–861.
Anderson, A. (1992). The evolution of sexes.Science 257:324–326.
Anderson, R. A., Baylor, S., and Zaneveld, Z. (1978). Alterations of male reproduction induced by chronic ingestion of ethanol: Development of an animal model.Fertil. Steril. 30:103–105.
Angelman, H. (1965). “Puppet” children: A report on three cases.Dev. Med. Child. Neurol. 7:453–460.
Aronson, J., and Solter, D. (1987). Developmental potency of gametic and embryonic genomes revealed by nuclear transfer.Curr. Topics Dev. Biol. 23:55–71.
Barrows, L. R., and Shank, R. C. (1981). Aberrant methylation of liver DNA in rats during hepatotoxicity.Toxicol. Appl. Pharmacol. 60:334–345.
Barton, S. C., Surani, M. A. H., and Norris, M. L. (1984). Role of paternal and maternal genomes in mouse development.Nature 311:374–376.
Bestor, T. H., and Ingram, V. M. (1983). Two DNA methyltransferases from murine erythroleukemia cells: Purification, sequence specificity and mode of interaction with DNA.Proc. Natl. Acad. Sci. USA 80:5559–5563.
Bestor, T., Laudano, A., Mattalino, R., and Ingram, V. (1988). Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells.J. Mol. Biol. 203:971–983.
Bird, A. P. (1986). CpG-rich islands and the function of DNA methylation.Nature 321:209–213.
Boyes, J., and Bird, A. (1991). DNA methylation inhibits transcription indirectly via a methyl-GpG binding protein.Cell 64:1123–1134.
Busslingler, M., Hurst, J., and Flovell, R. A. (1983). DNA methylation and the regulation of globin gene expression.Cell 34:197–206.
Cassidy, S. B. (1987). Recurrence risk in Prader-Willi syndrome.Am. J. Med. Genet. 28:59–60.
Cattanach, B. M., and Kirk, M. (1985). Differential activity of paternally and maternally derived chromosome regions in mice.Nature 315:496–498.
Cedar, H. (1988). DNA methylation and gene activity.Cell 53:3–4.
Chaillet, R. J., Vogt, T. F., Beier, D. R., and Leder, P. (1991). Parental-specific methylation of an imprinted transgene is established during gametogenesis and progressively changes during embryogenesis.Cell 66:77–83.
Donlon, T. A. (1988). Similar molecular deletions on chromosome 15q11.2 are encountered in both Prader-Willi and Angelman syndromes.Hum. Genet. 80:322–328.
Driscoll, C. D., Streissguth, A. P., and Riley, E. P. (1990). Prenatal alcohol exposure: Comparability of effects in humans and animal models.Neurotoxicol. Teratol. 12:231–237.
Engler, P., Haasch, D., Pinkert, C. A., Doglio, L., Glymour, M., Brinster, R., and Storb, U. (1991). A strain-specific modifier on mouse chromosome 4 controls the methylation of independent transgene loci.Cell 65:939–947.
Farrer, L. A., and Conneally, P. M. (1985). A genetic model for age of onset in Huntington disease.Am. J. Hum. Genet. 37:350–357.
Farrer, L. A., Cupples, L. A., Kiely, D. K., Conneally, P. M., and Myers, R. H., (1992). Inverse relationship between age of onset of Huntington disease and paternal age suggests involvement of genetic imprinting.Am. J. Hum. Genet. 50:528–535.
Forejt, J., and Gregorova, S. (1992). Genetic analysis of genomic imprinting: AnImprintor-1 gene controls inactivation of the paternal copy of the mouseTme locus.Cell 70:443–450.
Hadchouel, M., Farza, H., Simon, D., Tiollas, P., and Prorcel, C. (1987). Maternal inhibition of hepatitis B surface antigen gene expression in transgenic mice correlates with de novo methylation.Nature 329:454–456.
Haig, D., and Graham, C. (1991). Genomic imprinting and the strange case of the insulin-like growth factor II receptor. Cell64:1045–1046.
Haig, D., and Westoby, M. (1989). Parent specific gene expression and the triploid endosperm.Am. Nat. 134:147–155.
Haig, D., and Westoby, M. (1991). Genomic imprinting in endosperm: its effects on seed development in crosses between species, and between different ploidies of the same species and its implications for the evolution of apomixis.Phil. Trans. Roy. Soc. (London) 333:1–13.
Hall, J. G. (1990). Geonomic imprinting: review and relevance to human disease.Am. J. Med. Genet. 44:355–363.
Hoffman, M. (1991). How parents make their mark on genes.Science 252:1250–1251.
Kaufman, M. H. (1983).Early Mammalian Development: Parthenogenetic Studies, Cambridge University Press, Cambridge/New York.
Knoll, J. H. M., Nichills, R. D., Magenis, R. E., Graham, J. M., Jr., Lalande, M., and Latt, S. A. (1989). Angelman and Prader-Willi syndromes share a common chromosome 15 deletion by differ in the parent of origin of the deletion.Am. J. Med. Genet. 32:285–290.
Koufos, A., Grundy, P., Morgan, K., Aleck, K. A., Hadro, T., Lampkin, B. C., and Cavenee, W. C. (1985). Loss of heterozygosity in three embryonal tumours suggests a common pathogenetic mechanism.Nature 316:330–334.
Kouros, M., Monch, W., Reiffer, F. J., and Dehnen, W. (1983). The influence of various factors on the methylation of DNA by the oesophageal carcinogen N-nitrosomethylbenzylamine. The importance of ethanol.Carcinogenesis 4:1081–1084.
Levine, A., Cantoni, G., and Razin, A. (1991). Inhibition of promotor activity by methylation: Possible involvement of protein mediators.Proc. Natl. Acad. Sci. USA 82:2561–2564.
Lewis, J., and Bird, A. (1991). DNA methylation and chromatin structure.FEBS 285:155–159.
Lewis, J. D., Meehan, R. R., Henzel, W. J., Mauer-Fogy, I., Jeppesen, P., Klein, F., and Bird, A. (1992). Purification, sequence and cellular localization of a novel chromosomal protein that binds to methylated DNA.Cell 69:905–914.
Lyon, M. F. (1983). In Ishihara, T. (ed.),Radiation-Induced Damage in Man, Liss, New York, pp. 327–346.
Lyon, M. F., Ward, H. C., and Simpson, G. M. (1976). A genetic method for measuring non-disjunction in mice with Robertsonian translocations.Genet. Res. 26:283–295.
Malcolm, S., Clayton-Smith, J., Nicholls, M., Robb, S., Webb, T., Armour, J. A. L., Jeffreys, A. T., and Pembrey, M. E. (1991). Uniparental disomy in Angelman's syndrome.Lancet 337:694–697.
McGrath, J., and Solter, D. (1984). Completion of mouse embryogenesis requires both maternal and paternal genomes.Cell 37:179–183.
Mendel, G. (1865). Versuche uber Pflazen-Hybriden. Reprinted in, Stern, C., and Sherwood, E. R. (eds.),The Origin of Genetics: A Mendel Source Book, W. H. Freeman, San Francisco, 1966, pp. 1–48.
Merritt, A. D., Conneally, P. M., Rahman, N. F., and Drew, A. L. (1969). Juvenile Huntington's chorea. In Barbeau, A., and Brunette, J. R. (eds.),Progress in Neurogenetics, Excerpta Medica, Amsterdam, pp. 645–660.
Michaelis, E. K. (1990). Fetal alcohol exposure: cellular toxicity and molecular events involved in toxicity.Alcohol. Clin. Exp. Res. 14:819–826.
Murray, E. J., and Grosveld, F. (1987). Site specific demethylation in the promotor of the human gamma-globin gene does not alleviate methylation mediated suppression.EMBO J. 6:2329–2335.
Nicholls, R. D., Knoll, J. H. M., Butler, M. G., Karam, S., and Lalande, M. (1989). Genetic imprinting suggested by maternal heterodisomy in nondeletion Prader-Willi syndrome.Nature 342:281–285.
Prader, A., Labhart, A., and Willi, H., (1965). Ein syndrome von Adipositas, Kleinwuchs, Kryptorchismus und Oligophrenie nach myatonicrartigem Zustand in Neugeborenenalter.Schweiz. Med. Wochenschr. 86:1260–1261.
Razin, A., and Riggs, A. D. (1980). DNA methylation and gene function.Science 210:604–610.
Ridley, R. M., Farrer, L. A., Frith, C. D., and Conncally, P. M. (1992). A test of the hypothesis that age at onset in Huntington disease is controlled by an X-linked recessive modifier.Am. J. Hum. Genet. 50:536–543.
Riley, E. P. (1990). The long-term behavioral effects of prenatal exposure in rats.Alcohol. Clin. Exp. Res. 14:670–673.
Saitoh, S., Kubota, T., Ohta, T., Jinno, Y., Nikawa, N., Sugimoto, T., Wagstaff, J., and Lalande, M. (1992). Familial Angelman syndrome caused by imprinted submicroscopic deletion encompassing GABAA receptor β3-subunit gene.Lancet 339:366–367.
Sapienza, C., Tran, T.-H., Paquette, J., McGowan, R., and Peterson, A. (1989). Epigenetic and genetic factors affect transgene methylation imprinting.Development 107:165–168.
Searle, A. G., and Beechey, C. V. (1978). Complementation with mouse translocations.Cytogenet. Cell. Genet. 20:282–303.
Solter, D. (1988). Differential imprinting and expression of maternal and paternal genomes.Annu. Rev. Genet. 22:127–146.
Smith, K. J., and Eckardt, M. J. (1991). The effects of prenatal alcohol on the central nervous system.Recent Dev. Alcohol. 9:151–164.
Surani, M. A. H., Barton, S. C., and Norris, M. L. (1984). Development of reconstituted mouse eggs suggests imprinting of the genome during gametogenesis.Nature 308:548–550.
Surani, M. A., Reik, W., and Allen, N. D. (1986). Transgenes as molecular probes for genomic imprinting.Trends Genet. 4:59–62.
Surani, M. A., Allen, N. D., Barton, S. C., Fundele, R., Howlett, S. K., Norris, M. L., and Reik, W. (1990). Developmental consequences of imprinting of parental chromosomes by DNA methylation.Phil. Trans. Roy. Soc. Lond. B 326:313–327.
Swann, P. F., Coe, A. M., and Mace, R. (1984). Ethanol and dimethylnitrosamine metabolism and disposition in the rat. Possible relevance to the influence of ethanol on human cancer incidence.Carcinogenesis 5:1337–1343.
Wagstaff, J., Knoll, J. H. M., Fleming, J., Kirkness, E. F., Martin-Gallardo, A., Greenberg, F., Graham, J. M., Menninger, J., Ward, D., Venter, J. C., and Lalande, M. (1991). Localization of the gene encoding the GABAA receptor β3 subunit to the Angelman/Prader-Willi region of human chromosome 15.Am. J. Hum. Genet. 49:330–337.
West, J. R., and Goodlett, C. R. (1990). Teratogenic effects of alcohol on brain development.Ann. Med. 22:319–325.
Wozniak, D. F., Cicero, T. J., Kettinger, J., and Meyer, E. R. (1991). Paternal alcohol consumption in the rat impairs spatial learning performance in male offspring.Psychopharmacology 105:289–302.
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Durcan, M.J., Goldman, D. Genomic imprinting: Implications for behavioral genetics. Behav Genet 23, 137–143 (1993). https://doi.org/10.1007/BF01067418
- genomic imprinting
- neurobehavioral disorders
- paternal alcohol syndrome