Behavior Genetics

, Volume 24, Issue 3, pp 285–297 | Cite as

Evidence for a multigenic system controlling methyl-β-carboline-3-carboxylate (β-CCM)-induced seizures

  • Benoît Martin
  • Catherine Marchaland
  • Georges Chapouthier
  • Roland Motta


β-CCM is a β-carboline known to have properties opposite to those of benzodiazepines. Our approach was to analyze, in mice, the genetic mechanisms involved in β-CCM-induced myoclonic seizures using recombinant congenic strains and F1 hybrids issued from these strains. Our aim was to define the extent of the multigenic character of β-CCM-induced myoclonic seizures, while also evaluating the distribution of the strength of the genes implicated in this trait. The results show that the control of reactivity to β-CCM is multigenic with notable epistatic involvement.

Key Words

Recombinant congenic strains recombinant inbred strains β-carbolines methyl-β-carboline-3-carboxylate inverse agonist γ-aminobutyric acid mice 


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Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • Benoît Martin
    • 1
  • Catherine Marchaland
    • 1
  • Georges Chapouthier
    • 1
  • Roland Motta
    • 2
  1. 1.Génétique, Neurogénétique et Comportement, URA 1294-CNRSUFR Biomédicale Paris VParis Cedex 06France
  2. 2.Laboratoire de Recherche Génétique sur les Modèles Animaux (LRGMA) (CSAL)-CNRSOrleans Cedex 2France

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