Behavior Genetics

, Volume 2, Issue 1, pp 3–19

The investigation of linkage between a quantitative trait and a marker locus

  • J. K. Haseman
  • R. C. Elston
Article

Abstract

Procedures are given, using sib pairs, for estimating linkage between a knownm-allele locus and a hypothesized two-allele locus that governs a quantitative trait. Random mating and linkage equilibrium are assumed. Also given are parametric and nonparametric methods for detecting linkage when the trait in question is governed by several two-allele loci, provided there is no epistasis.

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Copyright information

© Plenum Publishing Corporation 1972

Authors and Affiliations

  • J. K. Haseman
    • 1
  • R. C. Elston
    • 2
  1. 1.National Institute of Environmental Health SciencesResearch Triangle Park
  2. 2.Department of Biostatistics and the Genetics CurriculumUniversity of North CarolinaChapel Hill

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