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Behavior Genetics

, Volume 22, Issue 6, pp 665–676 | Cite as

Inference in linkage analysis of multifactorial traits using recombinant inbred strains of mice

  • Paul E. Neumann
Article

Abstract

Recombinant inbred strains have been shown to be important tools for segregation and linkage analysis of multifactorial traits. Tests of association have been used as robust methods of linkage detection, however, guidelines for forming inferences from significance levels have not been generally available. In this paper, lessons learned from a Bayesian statistical approach to linkage analysis of Mendelian traits have been applied to studies of multifactorial traits. Criteria for detection of linkage based on Bonferroni's correction for multiple testing are also discussed.

Key Words

linkage analysis multifactorial traits mice recombinant inbred strains 

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Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • Paul E. Neumann
    • 1
  1. 1.Neurology ResearchChildren's Hospital and Harvard Medical SchoolBoston

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