Behavior Genetics

, Volume 22, Issue 6, pp 655–663

Chromosome mapping ofSoa, a gene influencing gustatory sensitivity to sucrose octaacetate in mice

  • Christopher G. Capeless
  • Glayde Whitney
  • Edwin A. Azen
Article

DOI: 10.1007/BF01066636

Cite this article as:
Capeless, C.G., Whitney, G. & Azen, E.A. Behav Genet (1992) 22: 655. doi:10.1007/BF01066636

Abstract

Strain distribution patterns among recombinant inbred strains suggested that a locus influencing taste sensitivity to sucrose octaacetate was on chromosome 6. A location forSoa was established by linkage analysis of behavioral and electrophoretic data from outbred and congenic strains and from test-cross progeny. Haplotyping of 41 outbred CFW-Cr animals with a cDNA probe showed perfect cosegregation ofSoa andPrp, a gene for salivary proline-rich proteins. Five of twelve B6. SW-Soaa strains were found to retainLdr-1, lactate dehydrogenase regulator-1, on chromosome 6 as an allelic passenger from the SWR/J donor strain (source of theSoaa Taster allele). Centimorgan distance was estimated using the ABP/Le linkage-testing strain (non-Taster,Soab) and the SWR/J strain (Taster,Soaa) in a testcross breeding system. The data are consistent with a position for theSoa locus on mouse chromosome 6, 62 cM from the centromere.

Key Words

chromosome mapping Soa sucrose octaacetate mice bitterness 

Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • Christopher G. Capeless
    • 1
  • Glayde Whitney
    • 1
  • Edwin A. Azen
    • 2
  1. 1.Department of PsychologyFlorida State UniversityTallahassee
  2. 2.Departments of Medicine and Medical GeneticsUniversity of WisconsinMadison

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