Behavior Genetics

, Volume 22, Issue 4, pp 415–433 | Cite as

The hyperactive spontaneously hypertensive rat learns to sit still, but not to stop bursts of responses with short interresponse times

  • Boaz Wultz
  • Terje Sagvolden
Article

Abstract

The spontaneously hypertensive rat (SHR) is hyperactive and has been proposed as an animal model of attention-deficit hyperactivity disorder (ADHD). Although ADHD in most cases is treated with central stimulants, behavior therapy has also been used, but with relatively limited success. The purpose of the present study was to investigate suppression of SRH hyperactivity by differentially reinforcing immobility (DRI) using a positive reinforcer. The DRI schedule required that the rat remain immobile in a particular part of an operant chamber, the target, in order to obtain the reinforcer. The time requirement, the DRI value, of these periods was increased progressively. The results showed that time spent on the target increased by increasing DRI value in both hyperactive and control rats. However, the total number of movements, on as well as outside the target, was higher for the hyperactive rats. The behavior grouped into two independent response components. One component consisted of immobility responses with durations less than 1 s, actually bursts of active responses; the other component consisted of immobility responses with durations more or less matching the DRI requirement. The reinforcement schedule modified the long-lasting immobility component in both groups. SHR received more reinforcers than WKY as long as the schedule did not require too long periods of immobility. However, the total number of movements on target was not reduced in SHR; on the contrary, it increased somewhat as the schedule requirements increased. If the behavior of ADHD children consists of two, or more, independent components similar to the ones observed in the present study, the present results may offer an explanation of why behavior therapy has limited success in the treatment of ADHD.

Key Words

rats spontaneously hypertensive rats hyperactivity hyperkinesis animal model behavior therapy behavior modification immobility differential reinforcement of immobility 

References

  1. American Psychiatric Association (1987).Diagnostic and Statistical Manual of Mental Disorders (3rd ed. —rev. ed.), APA, Washington, DC.Google Scholar
  2. Archer, T. (1989). Neurotoxin-induced cognitive and motor activity modifications: A catecholamine connection. In Sagvolden, T., and Archer, T. (eds.),Attention Deficit Disorder: Clinical and Basic Research, Lawrence Erlbaum Associates, Hillsdale, NJ; pp. 287–322.Google Scholar
  3. Bianchi, G., Ferrari, P., and Barber, B. R. (1990). Lessons from experimental genetic hypertension. In Laragh, J. H., and Brenner, B. M. (eds.),Hypertension: Pathophysiology, Diagnosis and Management, Raven, New York.Google Scholar
  4. Biederman, J., Faraone, S. V., Keenan, K., Knee, D., and Tsuang, M. T. (1990). Family-genetic and psychosocial risk factors in DSM-III Attention Deficit Disorder.J. Am. Acad. Child Adoles. Psychiat. 29:526–532.Google Scholar
  5. Bindra, D., and Anchel, H. (1963). Immobility as an avoidance response, and its disruption by drugs.J. Exp. Anal. Behav. 6:213–218.Google Scholar
  6. Blough, D. S. (1958). New test for tranquilizers.Science 127:586–587.Google Scholar
  7. Brener, J., and Goesling, W. J. (1970). Avoidance conditioning of activity and immobility in rats.J. Comp. Physiol. Psychol. 70:276–280.Google Scholar
  8. Catania, A. C. (1973). The concept of the operant in the analysis of behavior.Behaviorism 1:103–116.Google Scholar
  9. Catania, A. C. (1984).Learning (2nd ed.); Prentice-Hall, Englewood Cliffs; NJ.Google Scholar
  10. Conners, K. (1990). Diagnosis of attention deficit hyperactivity disorder (ADHD). In Conners, K., and Kinsbourne, M. (eds.),ADHD: Attention Deficit Hyperactivity Disorder, MMV Medizin Verlag Muenchen, München, pp. 17–36.Google Scholar
  11. Douglas, V. I. (1983). Attentional and cognitive problems. In Rutter, M. (ed.),Developmental Neuropsychiatry, Guilford Press, New York, pp. 280–329.Google Scholar
  12. Douglas, V. I., and Parry, P. A. (1983). Effects of reward on delayed reaction time task performance of hyperactive children.J. Abnorm. Child Psychiat. 11:313–326.Google Scholar
  13. Gentsch, C., Lichsteiner, M., and Feer, H. (1991). Genetic and environmental influences on reactive and spontaneous locomotor activities in rats.Experimentia 47:998–1008.Google Scholar
  14. Gittelman Klein, R., and Abikoff, H. (1989). The role of psychostimulants and psychosocial treatments in hyperkinesis. In Sagvolden, T., and Archer, T. (eds.),Attention Deficit Disorder: Clinical and Basic Research, Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 167–180.Google Scholar
  15. Gittelman Klein, R., and Mannuzza, S. (1989). The long-term outcome of the attention deficit disorder/hyperkinetic syndrome. In Sagvolden, T., and Archer, T. (eds.),Attention Deficit Disorder: Clinical and Basic Research, Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 71–91.Google Scholar
  16. Hendley, E. D., and Ohlsson, W. G. (1991). Two new inbred rat strains derived from SHR: WKHA, hyperactive, and WKHT, hypertensive rats.Am. J. Physiol. 261:H563-H569.Google Scholar
  17. Hendley, E. D., Atwater, D. G., Myers, M. M., and Whitehorn, D. (1983). Dissociation of genetic hyperactivity and hypertension in SHR.Hypertension 5:211–217.Google Scholar
  18. Hendley, E. D., Wessel, D. J., and Van Houten, J. (1986). Inbreeding of Wistar-Kyoto rat strain with hyperactivity but without hypertension.Behav. Neural Biol. 45:1–16.Google Scholar
  19. Knardahl, S., and Karlsen, K. (1984). Passive-avoidance behavior of spontaneously hypertensive rats.Behav. Neural Biol. 42:9–22.Google Scholar
  20. Knardahl, S., and Sagvolden, T. (1979). Open-field behavior of spontaneously hypertensive rats.Behav. Neural Biol. 27:187–200.Google Scholar
  21. Knardahl, S., and Sagvolden, T. (1982). Two-way active avoidance behavior of spontaneously hypertensive rats: Effect of intensity of discontinuous shock.Behav. Neural Biol. 35:105–120.Google Scholar
  22. McCarty, R., and Kopin, I. J. (1979). Patterns of behavioral development in spontaneously hypertensive rats and Wistar-Kyoto normotensive controls.Dev. Psychobiol. 12:239–243.Google Scholar
  23. Moser, M.-B., Moser, E. I., Wultz, B., and Sagvolden, T. (1988). Component analyses differentiate between exploratory behavior of spontaneously hypertensive rats and Wistar Kyoto rats in a two-compartment free-exploration open field.Scand. J. Psychol. 29:200–206.Google Scholar
  24. Murray, J. B. (1987). Psychophysiological effects of methylphenidate (ritalin).Psychol. Rep. 61:315–336.Google Scholar
  25. Myers, M. M., Musty, R. E., and Hendley, E. D. (1982). Attenuation of hyperactivity in the spontaneously hypertensive rat by amphetamine.Behav. Neural Biol. 34:42–54.Google Scholar
  26. Norusis, M. J. (1985).SPSS-X Advanced Statistics Guide, SPSS Inc., Chicago.Google Scholar
  27. Okamoto, K., and Aoki, K. (1963). Development of a strain of spontaneously hypertensive rats.Jap. Circ. J. 27:282–293.Google Scholar
  28. Parry, P. A., and Douglas, V. I. (1983). Effects of reinforcement on concept identification in hyperactive children.J. Abnorm. Child Psychol. 11:327–340.Google Scholar
  29. Premack, D. (1962). Reversibility of the reinforcement relation.Science 136:255–257.Google Scholar
  30. Rapoport, J. L. (1983). The use of drugs: Trends in research. In Rutter, M. (ed.),Developmental Neuropsychiatry, Churchill Livingstone, New York, pp. 385–403.Google Scholar
  31. Robbins, T. W., Jones, G. H., and Sahakian, B. J. (1989). Central stimulants, transmitters and attentional disorder: A perspective from animal studies. In Sagvolden, T., and Archer, T. (eds.),Attention Deficit Disorder: Clinical and Basic Research, Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 199–222.Google Scholar
  32. Rutter, M., Macdonald, H., Le Couteur, A., Harrington, R., Bolton, P., and Bailey, A. (1990). Genetic factors in child psychiatric disorders. II. Empirical findings.J. Child Psychol. Psychiat. 31:39–83.Google Scholar
  33. Sagvolden, T., and Archer, T. (1989). Future perspectives on ADD research—An irresistible challenge. In Sagvolden, T., and Archer, T. (eds.),Attention Deficit Disorder: Clinical and Basic Research, Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 369–389.Google Scholar
  34. Sagvolden, T., Wultz, B., Moser, E. I., Moser, M. B., and Mørkrid, L. (1989). Results from a comparative neuropsychological research program indicate altered reinforcement mechanisms in children with ADD. In Sagvolden, T., and Archer, T. (eds.),Attention Deficit Disorder: Clinical and Basic Research, Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 261–286.Google Scholar
  35. Sagvolden, T., Hendley, E. D., and Knardahl, S. (1991a). Behavior of hypertensive and hyperactive rat strains: Hyperactivity is not unitarily determined.Physiol. Behav. 52, in press.Google Scholar
  36. Sagvolden, T., Metzger, M. A., Schiørbeck, H. K., Rugland, A.-L., Spinnangr, I., and Sagvolden, G. (1991b). Spontaneously hypertensive rats (SHR) as an animal model of childhood hyperactivity (ADHD): Changed reactivity to reinforcers and to psychomotor stimulants.Behav. Neural Biol., in press.Google Scholar
  37. Sergeant, J., and van der Meere, J. J. (1989). The diagnostic significance of attentional processing: Its significance for ADDH classification—A future DSM. In Sagvolden, T., and Archer, T. (eds.),Attention Deficit Disorder: Clinical and Basic Research, Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 151–166.Google Scholar
  38. Shaywitz, B. A., Yager, R. D., and Klopper, J. H. (1976). Selective brain dopamine depletion in developing rats: An experimental model of minimal brain dysfunction.Science 191:305–308.Google Scholar
  39. Silbergeld, E. K., and Goldberg, A. M. (1974). Lead-induced behavioral dysfunction: An animal model of hyperactivity.Exp. Neurol. 42:146–157.Google Scholar
  40. Skinner B. F. (1938).The Behavior of Organisms, Appleton-Century-Crofts, New York.Google Scholar
  41. Stevenson, J. G., and Clayton, F. L. (1970). A response duration schedule: Effects of training, extinction, and deprivation.J. Exp. Anal. Behav. 13:359–367.Google Scholar
  42. Stevenson-Hinde, J., and Roper, R. (1975). Individual differences in reinforcing effects of song.Anim. Behav. 23:729–734.Google Scholar
  43. Wultz, B., Sagvolden, T., Moser, M. B., and Moser, E. I. (1990). Methylphenidate effects on the exploratory behavior of SHR and WKY rats in a two-compartment free-exploration open field.Behav. Neural Biol. 53:88–102.Google Scholar

Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • Boaz Wultz
    • 1
  • Terje Sagvolden
    • 1
  1. 1.Department of NeurophysiologyUniversity of OsloOsloNorway

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