Phenylthiocarbamide (PTC) preference among laboratory mice: Understanding of a previously “unreplicated” report
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In two-bottle preference tests aversion to phenylthiocarbamide (PTC) develops over a period of days. Thus, as previously reported, following experience with appropriate concentrations of PTC, mice of the BALB inbred strain display an aversion in contrast to C57BL inbred mice. It is suggested that differential learning in a conditioned taste-aversion paradigm might be responsible for the phenotypic strain contrast. The difference in PTC aversion phenotype among mice could be due to differences in any mechanism contributing to differential flavor toxicosis conditioning instead of, or in addition to, strain differences in sensitivity to the sensory attributes of PTC.
Key Wordsphenylthiocarbamide PTC taste genetics conditioned aversion mouse
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- Barker, L. B., Best, M. R., and Domjan, M. (eds.) (1977).Learning Mechanisms in Food Selection, Baylor University Press, Waco, Tex.Google Scholar
- Blakeslee, A. F. (1932). Genetics of sensory thresholds: Taste for phenylthiocarbamide.Proc. Natl. Acad. Sci. 18:120–130.Google Scholar
- Fischer, R., and Griffin, F. (1964). Pharmacogenetic aspects of gustation.Drug Res. (Arzneimittel-Forschung) 14:673–686.Google Scholar
- Harder, D. B., and Whitney, G. (1982). Taste psychophysics of sucrose octaacetate in mice.Behav. Genet. 12:586.Google Scholar
- Harder, D. B., Whitney, G., Frye, P., Smith, J. C., and Rashotte, M. E. (1984). Strain differences among mice in taste psychophysics of sucrose octaacetate.Chem. Senses 9:311–323.Google Scholar
- Klein, T. W. (1969),Phenolthiourea (PTC) Taste Sensitivity in Mice, Unpublished master's thesis, University of Colorado, Boulder.Google Scholar
- Lush, I. E. (1981) The genetics of tasting in mice. I. Sucrose octaacetate.Genet. Res. (Cambr.) 38:93–95.Google Scholar
- Richter, C. P. (1939). Salt taste threshold of normal and adrenolectomized rats.Endocrinology 24:367–371.Google Scholar
- Richter, C. P., and Clisby, K. H. (1941). PTC taste thresholds of rats and human beings.Am. J. Physiol. 134:157–164.Google Scholar
- Salmon, T. N., and Blakeslee, A. F. (1935). Genetics of sensory thresholds: Variations within single individuals in taste sensitivity for PTC.Proc. Natl. Acad. Sci.,21:78–83.Google Scholar