Behavior Genetics

, Volume 16, Issue 6, pp 605–610 | Cite as

Phenylthiocarbamide (PTC) preference among laboratory mice: Understanding of a previously “unreplicated” report

  • Glayde Whitney
  • David B. Harder
Letter to the Editor

Abstract

In two-bottle preference tests aversion to phenylthiocarbamide (PTC) develops over a period of days. Thus, as previously reported, following experience with appropriate concentrations of PTC, mice of the BALB inbred strain display an aversion in contrast to C57BL inbred mice. It is suggested that differential learning in a conditioned taste-aversion paradigm might be responsible for the phenotypic strain contrast. The difference in PTC aversion phenotype among mice could be due to differences in any mechanism contributing to differential flavor toxicosis conditioning instead of, or in addition to, strain differences in sensitivity to the sensory attributes of PTC.

Key Words

phenylthiocarbamide PTC taste genetics conditioned aversion mouse 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aravich, P. F., and Sclafani, A. (1980). Dietary preference behavior in rats fed bitter tasting quinine and sucrose octa acetate adulterated diets.Physiol. Behav. 25:157–160.PubMedGoogle Scholar
  2. Barker, L. B., Best, M. R., and Domjan, M. (eds.) (1977).Learning Mechanisms in Food Selection, Baylor University Press, Waco, Tex.Google Scholar
  3. Blakeslee, A. F. (1932). Genetics of sensory thresholds: Taste for phenylthiocarbamide.Proc. Natl. Acad. Sci. 18:120–130.Google Scholar
  4. Fischer, R., and Griffin, F. (1964). Pharmacogenetic aspects of gustation.Drug Res. (Arzneimittel-Forschung) 14:673–686.Google Scholar
  5. Fuller, J. L. (1974). Single-locus control of saccharin preference in mice.J. Hered. 65:33–36.PubMedGoogle Scholar
  6. Harder, D. B., and Whitney, G. (1982). Taste psychophysics of sucrose octaacetate in mice.Behav. Genet. 12:586.Google Scholar
  7. Harder, D. B., Whitney, G., Frye, P., Smith, J. C., and Rashotte, M. E. (1984). Strain differences among mice in taste psychophysics of sucrose octaacetate.Chem. Senses 9:311–323.Google Scholar
  8. Horowitz, G. P., and Whitney, G. (1975). Alcohol-induced conditioned aversion: Genotypic specificity in mice (Mus musculus).J. Comp. Physiol. Psychol.,89:340–346.PubMedGoogle Scholar
  9. Klein, T. W. (1969),Phenolthiourea (PTC) Taste Sensitivity in Mice, Unpublished master's thesis, University of Colorado, Boulder.Google Scholar
  10. Klein, T. W., and DeFries, J. C. (1970). Similar polymorphism of taste sensitivity to PTC in mice and men.Nature 225:555–557.PubMedGoogle Scholar
  11. Lush, I. E. (1981) The genetics of tasting in mice. I. Sucrose octaacetate.Genet. Res. (Cambr.) 38:93–95.Google Scholar
  12. Richter, C. P. (1939). Salt taste threshold of normal and adrenolectomized rats.Endocrinology 24:367–371.Google Scholar
  13. Richter, C. P., and Clisby, K. H. (1941). PTC taste thresholds of rats and human beings.Am. J. Physiol. 134:157–164.Google Scholar
  14. Salmon, T. N., and Blakeslee, A. F. (1935). Genetics of sensory thresholds: Variations within single individuals in taste sensitivity for PTC.Proc. Natl. Acad. Sci.,21:78–83.Google Scholar
  15. Warren, R. P., and Lewis, R. C. (1970). Taste polymorphism in mice involving a bitter sugar derivative.Nature 227:77–78.PubMedGoogle Scholar
  16. Wysocki, C. J., Whitney, G., and Tucker, D. (1977). Specific anosmia in the laboratory mouse.Behav. Genet. 7:171–188.PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Glayde Whitney
    • 1
  • David B. Harder
    • 1
  1. 1.Department of PsychologyFlorida State UniversityTallahassee

Personalised recommendations