Behavior Genetics

, Volume 5, Issue 3, pp 217–231 | Cite as

Open-field behavior in mice: A diallel analysis of selected lines

  • R. A. Halcomb
  • J. P. Hegmann
  • J. C. DeFries


The open-field behavior of 719 mice resulting from a diallel cross among the six lines of the DeFries selection experiment was assessed. Results of several analyses employing different models and procedures were highly consistent and indicated that genes responsible for differences in open-field activity and defecation among these lines have predominantly additive effects. Estimates of heritability obtained from these analyses were considerably higher than previous estimates based on familial resemblance or the realized response to selection; thus estimation of heritability from diallel analyses is clearly unwarranted when selected lines are employed and the character of interest has been either directly or indirectly subjected to artificial selection.

Key Words

open-field behavior mice diallel analysis selected lines 


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  1. Archer, J. (1973). Tests for emotionality in rats and mice: A review.Anim. Behav. 21:205–235.Google Scholar
  2. Broadhurst, P. L. (1960). Experiments in psychogenetics: Applications of biometrical genetics to the inheritance of behaviour. In Eysenck, H. J. (ed.)Experiments in Personality, Vol. 1:Psychogenetics and Psychopharmacology, Routledge and Kegan Paul, London.Google Scholar
  3. DeFries, J. C. 1969). Pleiotropic effects of albinism on open field behaviour in mice.Nature 221:65–66.Google Scholar
  4. DeFries, J. C., and Hegmann, J. P. (1970). Genetic analysis of open-field behavior. In Lindzey, G., and Thiessen, D. D. (eds.),Contributions to Behavior-Genetic Analysis: The Mouse as a Prototype, Appleton-Century-Crofts, New York.Google Scholar
  5. DeFries, J. C., Hegmann, J. P., and Weir, M. W. (1966). Open-field behavior in mice: Evidence for a major gene effect mediated by the visual system.Science 154:1577–1579.Google Scholar
  6. DeFries, J. C., Wilson, J. R., and McLearn, G. E. (1970). Open-field behavior in mice: Selection response and situational generality.Behav. Genet. 1:195–211.Google Scholar
  7. Eysenck, H. J., and Broadhurst, P. L. (1964). Experiments with animals: Introduction. In Eysenck, H. J. (ed.),Experiments in Motivation, Macmillan, New York.Google Scholar
  8. Falconer, D. S. (1960).Introduction to Quantitative Genetics, Ronald Press, New York.Google Scholar
  9. Falconer, D. S. (1963). Quantitative inheritance. In Burdette, W. J. (ed.),Methodology in Mammalian Genetics, Holden-Day, San Francisco.Google Scholar
  10. Fulker, D. W. (1966). Mating speed in maleDrosophila melanogaster: A psychogenetic analysis.Science 153:203–205.Google Scholar
  11. Griffing, B. (1956). Concept of general and specific combining ability in relation to diallel crossing systems.Aust. J. Biol. Sci. 9:463–493.Google Scholar
  12. Hall, C. S. (1934). Emotional behavior in the rat. I. Defecation and urination as measures of individual differences in emotionality.J. Comp. Physiol. Psychol. 18:385–403.Google Scholar
  13. Harvey, W. R. (1960).Least Squares Analysis of Data with Unequal Subclass Numbers, No. ARS-20-8, U.S.D.A. Washington, D.C.Google Scholar
  14. Hegmann, J. P., Kieso, R. A., and Hartman, H. B. (1974). Gene differences influencing visual system function and behavior.Behav. Genet. 4:165–170.Google Scholar
  15. Henderson, N. D. (1967). Prior treatment effects on open field behaviour of mice—A genetic analysis.Anim. Behav. 15:364–376.Google Scholar
  16. McClearn, G. E., and DeFries, J. C. (1973).Introduction to Behavioral Genetics, Freeman, San Francisco.Google Scholar

Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • R. A. Halcomb
    • 1
  • J. P. Hegmann
    • 2
  • J. C. DeFries
    • 1
  1. 1.Institute for Behavioral GeneticsUniversity of ColoradoBoulder
  2. 2.Department of ZoologyUniversity of IowaIowa City

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