Scores on a vocabulary test given to members of 1818 nuclear families of different ethnic backgrounds were subjected to admixture analysis, segregation analysis utilizing both the mixed model and the transmission probability model and linkage analysis with 16 polymorphic markers. The data fitted a commingled distribution better than a unimodal distribution. Tests of the hypothesis that a major gene was segregating were not rejected by mixed model segregation analysis or by transmission probability analysis when provision was made for contribution from factors other than a major gene. There was no detectable heterogeneity by ethnic group nor by mating type. These analyses provide consistent support that there is a major gene for a component of verbal ability measured by a vocabulary test, and the segregation pattern is consistent with the expected Mendelian ratios. When vocabulary scores were adjusted for covariates including years of education, academic achievement, and reading habits, evidence for a major locus was lacking. The results of the linkage analysis were inconclusive. Current segregation models are affected by various factors leading to false inferences regarding monogenic mechanisms; however, in many respects, the mixed model and the transmission probability model are complementary with respect to power and robustness. The results of the analysis are discussed in this context.
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Ashton, G. C., Polovina, J. J., and Vandenberg, S. G. (1979). Segregation analysis of family data for 15 tests of cognitive ability.Behav. Genet. 9:329–347.
Bock, R. D., Vandenberg, S. G., Bramble, W., and Pearson, W. (1970). A behavioral correlate of blood group discordance in dizygotic twins.Behav. Genet. 1:89–98.
Elston, R. C. (1979). Major locus analysis for quantitative traits.Am. J. Hum. Genet. 31:655–661.
Elston, R. C. (1982). Modern methods of segregation analysis. Invited paper at the Sixth Australian Statistical Conference, University of Melbourne, August.
Go, R. C. P., Elston, R. C., and Kaplan, E. B. (1978). Efficiency and robustness of pedigree segregation analysis.Am. J. Hum. Genet. 30:28–37.
Karlin, S., Williams, P. T., and Carmelli, D. (1981). Structured exploratory data analysis (SEDA) for determining mode of inheritance of quantitative traits. I. Simulation studies on the effect of background distribution.Am. J. Hum. Genet. 33:262–281.
Lalouel, J. M., and Morton, N. E. (1981). Complex segregation analysis with pointers.Hum. Hered. 31:312–321.
Lalouel, J. M., Rao, D. C., Morton, N. E., and Elston, R. C. (1983). A unified model for complex segregation analysis.Am. J. Hum. Genet. 35:816–826.
Lalouel, J. M., Yee, S. (1980). POINTER: A computer program for complex segregation analysis with pointers. Technical report, Population Genetics Laboratory, University of Hawaii, Honolulu.
MacLean, C. J., Morton, N. E., and Lew, R. (1975). Analysis of family resemblance. IV. Operational characteristics of segregation analysis.Am. J. Hum. Genet. 27:365–384.
MacLean, C. J., Morton, N. E., Elston, R. C., and Yee, S. (1976). Skewness in commingled distributions.Biometrics 32:695–699.
Morton, N. E., and MacLean, C. J. (1974). Analysis of family resemblance. III. Complex segregation of quantitative traits.Am. J. Hum. Genet. 26:489–503.
Morton, N. E., Gulbrandsen, C. L., Rhoads, G. G., Kagan, A., and Lew, R. (1978). Major loci for lipoprotein concentrations.Am. J. Hum. Genet. 30:583–589.
Ott, J. (1974). Estimation of the recombination fraction in human pedigrees: Efficient computation of the likelihood for human linkage studies.Am J. Hum. Genet. 26:588–597.
Rose, R. J., Procidano, M. E., Conneally, M., and Yu, P. (1979). Blood group discordance and verbal intelligence: Analyses in offspring of MZ twins.Behav. Genet. 9:478–479.
Thurstone, L. L., and Thurstone, T. G. (1947).SRA Primary Mental Abilities, Science Research Associates, Chicago.
Wilson, J. R., and Vandenberg, S. G. (1977). Sex differences in cognition: Evidence from the Hawaii Family Study. In McGill, T. E., Dewsburg, D. A., and Sachs, B. D. (eds.),Sex and Behavior, Plenum Press, New York, pp. 317–335.
We thank Dr. J. M. Lalouel for access to his modified POINTER program, Professor N. E. Morton for access to NUCLEAR and POINTER, and Professor R. C. Elston for his support. The results reported here are made possible by collaboration of a group of investigators (G. C. Ashton, R. C. Johnson, M. P. Mi, and M. N. Rashad at the University of Hawaii and J. C. DeFries, G. E. McClearn, S. G. Vandenberg, and J. R. Wilson at the University of Colorado), supported by NSF Grant GB34720 and National Institute of Child Health and Human Development Grant HD06669.
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Borecki, I.B., Ashton, G.C. Evidence for a major gene influencing performance on a vocabulary test. Behav Genet 14, 63–79 (1984). https://doi.org/10.1007/BF01066069
- verbal ability
- vocabulary test
- admixture analysis
- mixed model segregation analysis
- transmission probability model segregation analysis
- linkage analysis