Relation between morphine pharmacokinetics and analgesia
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The relationship between the multicompartmental behavior of morphine and the kinetics of the analgesic effect has been investigated using a digital computer compartment analysis program. The results obtained indicate that the concentrations of morphine in the brain are not related to the analgesic effect in a “direct” manner but rather in an “indirect” way. A compartment model describing the kinetics of such an “indirect” pharmacological effect was found to yield a good correlation between the Pharmacokinetics of morphine and the kinetics of the analgesic effect.
Key wordsmorphine pharmacokinetics morphine analgesic activity relationships between morphine pharmacokinetics and analgesic effect multicompartmental behavior of morphine
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