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Relation between morphine pharmacokinetics and analgesia

  • Bengt E. Dahlström
  • Lennart K. Paalzow
  • Giorgio Segre
  • Allan J. Ågren
Article

Abstract

The relationship between the multicompartmental behavior of morphine and the kinetics of the analgesic effect has been investigated using a digital computer compartment analysis program. The results obtained indicate that the concentrations of morphine in the brain are not related to the analgesic effect in a “direct” manner but rather in an “indirect” way. A compartment model describing the kinetics of such an “indirect” pharmacological effect was found to yield a good correlation between the Pharmacokinetics of morphine and the kinetics of the analgesic effect.

Key words

morphine pharmacokinetics morphine analgesic activity relationships between morphine pharmacokinetics and analgesic effect multicompartmental behavior of morphine 

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Copyright information

© Plenum Publishing Corporation 1978

Authors and Affiliations

  • Bengt E. Dahlström
    • 1
  • Lennart K. Paalzow
    • 1
    • 2
  • Giorgio Segre
    • 3
  • Allan J. Ågren
    • 4
  1. 1.Department of Pharmacology, Faculty of PharmacyUniversity of Uppsala, Biomedical CenterUppsalaSweden
  2. 2.CentrallaboratorietSolna 3Sweden
  3. 3.Department of PharmacologyUniversity of SienaSienaItaly
  4. 4.Department of Inorganic and Physical Pharmaceutical ChemistryUniversity of Uppsala, Biomedical CenterUppsalaSweden

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