Starlings (Sturnus vulgaris) were dosed with corn oil, demeton-S-methyl (S-[2-(ethyl thio)ethyl]O,O dimethyl phosphorothioate) or triazophos (O,O-diethyl-O-(1-phenyl-1H-1,2,4-triazol-3-yl)phosphorothioate). Brain and serum esterase activities were measured up to 24 h after dosing. A dose response relationship was observed in serum cholinesterase and carboxylesterase activities following dosing with both pesticides. An increase in serum carboxylesterase activity was observed following exposure to a low dose of demeton-S-methyl, whereas inhibition was observed at higher doses. These results highlighted the need for the development of a method for monitoring exposure which takes into account both release and inhibition of the enzyme.
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Thompson, H.M., Walker, C.H. & Hardy, A.R. Changes in activity of avian serum esterases following exposure to organophosphorus insecticides. Arch. Environ. Contam. Toxicol. 20, 514–518 (1991). https://doi.org/10.1007/BF01065841
- Dose Response
- Response Relationship