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Gene differences influencing visual system function and behavior

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Behavioral differences between albino (cc) and pigmented (C) mice are mimicked by animals homozygous for a recessive allele (p) 13 map units from thec locus. Electroretinograms forcc andpp animals are similar, showing greatly enhanced a- and b-waves compared to normals (C). The behavioral and retinal physiology similarities of albino (cc) and dilute pigmented (pp) mice probably result from increased sensitivity to illumination. Recently reported decreased ipsilateral retinogeniculate projections characteristic ofcc animals may result from genotype — visual environment interactions rather than from pleiotropic effects of thec locus.

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Supported in part by N. 1. H. Grants NS09536 and NS70099 to J. P. H.

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Hegmann, J.P., Kieso, R.A. & Hartman, H.B. Gene differences influencing visual system function and behavior. Behav Genet 4, 165–170 (1974). https://doi.org/10.1007/BF01065757

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Key Words

  • visual system
  • genetics
  • behavior open field
  • mice
  • single gene