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Estimation of the blood-plasma concentration ratio of diazepam in the rat

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    Y. Igari, Y. Sugiyama, Y. Sawada, T. Iga, and M. Hanano. Prediction of diazepam disposition in the rat and man by a physiologically based pharmacokinetic model.J. Pharmacokin. Biopharm. 11:577–593 (1983).

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    U. Klotz, K.-H. Antonin, and P. R. Bieck. Pharmacokinetics and plasma binding of diazepam in man, dog, rabbit, guinea pig and rat.J. Pharmacol. Exp. Ther. 199:67–73 (1976).

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    U. Klotz, G. R. Avant, A. Hoyumpa, S. Schenker, and G. R. Wilkinson. The effects of age and liver disease on the disposition and elimination of diazepam in adult man.J. Clin. Invest. 55:347–359 (1975).

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    I. A. Zingales. Diazepam metabolism during chronic medication, unbound fraction in plasma, erythrocytes and urine.J. Chromatogr. 75:55–78 (1973).

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Klotz, U. Estimation of the blood-plasma concentration ratio of diazepam in the rat. Journal of Pharmacokinetics and Biopharmaceutics 13, 347–348 (1985). https://doi.org/10.1007/BF01065659

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  • Diazepam
  • Plasma Protein Binding
  • Unbind Fraction
  • Plasma Binding
  • Chronic Medication