Comparison of the localization of monoamines and monoamine oxidase in the rabbit hippocampus shows that most pyramidal and all granular neurons contain no monoamines. Up to 1% of pyramidal and about 3% of polymorphic neurons are noradrenergic, and some of the latter are basket cells. Their terminals, containing both noradrenalin and monoamine oxidase, are in contact with the bodies and processes of the pyramidal and granular neurons. Single serotoninergic polymorphic neurons are found in sectors H1 and H2 of the cornu ammonis and in sector H5 of the fascia dentata of the hippocampus; they have few terminals. Noradrenergic afferents enter the cornu ammonis in the external bundle of the alveus and in the septal tract, which runs along the inner surface of the fimbria. Noradrenergic terminal plexuses surround the bodies of the pyramidal cells and are concentrated at the level of the apical dendrites of the pyramids and at the base of the granular neurons of the fascia dentata. Convergence of noradrenergic and serotoninergic terminals is found on some pyramidal, granular, and polymorphic neurons. The high concentration of serotonin in the hippocampus despite the minimal number of serotoninergic neurons can be explained by the large number of serotonin-containing stellate cells of nonneural nature. They are localized on groups of pyramidal neurons in sectors H1 and H2 and also on blood vessels. Individual variations are found in the number of serotonin-containing neurons in the hippocampus and in the number and distribution of serotonin-containing stellate cells.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
E. A. Gromova, Serotonin and Its Role in the Organism [in Russian], Meditsina, Moscow (1966).
L. O. Gromova, "Serotoninergic mechanisms of convulsions," Ukr. Biokhim. Zh.,44, 108 (1972).
V. A. Krauz and Yu. S. Borodkin, "Effect of exogenous and endogenous serotonin on the hippocampal-reticular complex," Farmakol. i Toksikol.,35, 12 (1972).
I. V. Tors'ka and L. F. Burchyns'ka, "Localization of acetylcholinesterase in neurons of the rabbit hippocampus," Fiziol. Zh. (Ukr.),15, 358 (1969).
P. Andersen, J. C. Eccles, and Y. Loyning, "Location of postsynaptic inhibitory synapses on hippocampal pyramid," J. Neurophysiol.,27, 592 (1963).
J. Axelrod, W. Albers, and C. D. Clemente, "Distribution of catechol-O-methyltransferase in the nervous system and other tissues," J. Neurochem.,5, 68 (1959).
P. C. Baker and W. B. Quay, "5-Hydroxytryptamine metabolism in early embryogenesis and the development of brain and retinal tissues," Brain Res.,12, 273 (1969).
A. Bertler and E. Rosengren, "Occurrence and distribution of catecholamines in brain," Acta Physiol. Scand.,47, 350 (1959).
A. Bertler, "Occurrence and localization of catecholamines in the human brain," Acta Physiol. Scand.,51, 97 (1961).
T. J. Biscoe and D. W. Straughan, "Micro-electrophoretic studies of neurons in the cat hippocampus," J. Physiol. (London),183, 341 (1966).
T. W. Blackstad, K. Fuxe, and T. Hokfelt, "Noradrenaline nerve terminals in the hippocampal region of the rat and the guinea-pig," Z. Zellforsch.,78, 463 (1967).
D. F. Bogdanski, H. Weissbach, and S. Udenfriend, "The distribution of serotonin, 5-hydroxytryptophan decarboxylase and monoamine oxidase in brain," J. Neurochem.,1, 272 (1957).
D. F. Bogdanski, H. Weissbach, and S. Udenfriend, "Pharmacological studies with the serotonin precursor 5-hydroxytrytophan," J. Pharmacol. Exp. Ther.,122, 182 (1958).
B. B. Brodie, S. Spector, and P. A. Shore, "Interaction of drugs with norepinephrine in the brain," Pharmacol. Rev.,11, 548 (1959).
A. Carlsson, J. Jonason, M. Lindqvist, and K. Fuxe, "Demonstration of extraneuronal 5-hydroxytryptamine accumulation in brain following membrane-pump blockade by chlorimipramine," Brain Res.,12, 456 (1969).
A. Dahlstrom and K. Fuxe, "Evidence for the existence of monoamine-containing neurons in the central nervous system. 1. Determination of monoamines in the cells bodies of brain stem neurons," Acta Physiol. Scand., 62, Suppl. 232 (1964).
A. Dahlstrom and K. Fuxe, "Evidence for the existence of monoamine neurons in the central nervous system. 2. Experimentally induced changes in the interneuronal amine levels of bulbospinal neuron system. 4. The distribution of monoamine terminals in the CNS," Acta Physiol. Scand.,64, Suppl. 247 (1965).
E. Eidelberg et al., "Evidence for serotonin as a possible inhibitory transmitter in some limbic structures," Exp. Brain Res.,4, 73 (1967).
O. Eranko and M. Harkonen, "Histochemical demonstration of fluorogenic amines in the cytoplasm of sympathetic ganglion cells of the rat," Acta Physiol. Scand.,58, 285 (1963).
B. Falck, "Observations on the possibilities of the cellular localization of monoamines by the fluorescence method," Acta Physiol. Scand.,56, Suppl. 197 (1962).
B. Falck and C. Owman, "A detailed methodological description of the fluorescent method for the cellular demonstration of biogenic monoamines," Acta Univ. Lundensis, Sect. 2 (1965).
K. Fuxe, T. Hokfelt, G. Jonsson, and U. Ungerstedt, "Fluorescence microscopy in neuroanatomy," in: W. J. H. Nauta and S. O. E. Ebbeson (Editors). Contemporary Research Methods in Neuroanatomy, Berlin, Heidelberg, and New York (1970), pp. 275–314.
J. Glowinski and L. L. Iversen, "Regional studies of catecholamines in the rat brain. 1. The disposition of3H norepinephrine,3H dopamine and3H DOPA in various regions of the brain," J. Neurochem.,13, 655 (1966).
L. L. Iversen and J. Glowinski, "Regional studies of catecholamines in the rat brain. 2. Rate of turnover of catecholamines in various brain regions," J. Neurochem.,13, 671 (1966).
N. Jasumitsu and S. Jasuhiro, "Electron-microscopic autoradiography on the localization of serotonin in the frog median eminence," Z. Zellforsch.,119, 326 (1971).
K. Kataoka, "Subcellular distribution of 5-hydroxytryptamine in the rabbit brain," Jap. J. Physiol.,12, 623 (1962).
H. J. Lammers and H. Gastaut, "Relations cyto-architectoniques et enzyme-architectoniques dans l'hippocampe," in: Physiologie de l'Hippocampe, Paris (1962), pp. 13–21.
M. K. Paasonen et al., "5-Hydroxytryptamine (serotonin, enteramine) content structures of the limbic system," J. Neurochem.,1, 326 (1957).
M. Roberts and D. Straughan, "Excitation and depression of cortical neurones by 5-hydroxytryptamine," J. Physiol. (London),193, 269 (1967).
A. A. Bogomolets' Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 5, No. 1, pp. 40–46, January–February, 1973.
About this article
Cite this article
Torskaya, I.V., Burchinskaya, L.F. & Korotchenko, V.V. Localization of biogenic amines and monoamine oxidase in the rabbit hippocampus. Neurophysiology 5, 30–36 (1973). https://doi.org/10.1007/BF01065209
- Blood Vessel
- Individual Variation
- Pyramidal Neuron