Psychiatric Quarterly

, Volume 64, Issue 4, pp 345–358

Genetic and biologic risk factors for suicide in depressive disorders

  • Alec Roy


Over the last few years data have accumulated suggesting that there may be genetic and biologic risk factors for suicide. This paper reviews studies from clinical populations, twins, the Amish, as well as data from the Iowa-500 and Danish-American adoption studies which suggest that there may be a genetic factor predisposing to suicide. The paper also reviews neurochemical data from cerebrospinal fluid, urine and postmortem studies which suggest that diminished central serotonin and dopamine may be implicated in suicidal behavior.


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  1. 1.
    Roy, A. Suicide in Comprehensive Textbook of Psychiatry, 5th ed. Edited by Kaplan, H., Sadock, B. Baltimore, Williams and Wilkins, 1989.Google Scholar
  2. 2.
    Pitts, F., and Winokur, G. Affective disorder. Part II (Diagnostic correlates and incidence of suicide). Journal of Nervous and Mental Disorders,139 176–181, 1984.Google Scholar
  3. 3.
    Roy, A. Family history of suicide. Archives of General Psychiatry, 40, 971–974, 1983.Google Scholar
  4. 4.
    Linkowski, P., de Maertelaer, V., Mendlewicz, J. Suicidal behavior in major depressive illness. Acta Psychiatrica Scandinavica 72, 233–238, 1985.Google Scholar
  5. 5.
    Roy, A. Risk factors for suicide in psychiatric patients. Archives of General Psychiatry, 39, 1089–1095, 1982.Google Scholar
  6. 6.
    Roy, A. Family history of suicide in affective disorder patients. Journal of Clinical Psychiatry, 46, 317–319, 1985.Google Scholar
  7. 7.
    Roy, A. Genetics of suicide. In J. Mann, & M. Stanley (eds.), Psychobiology of Suicidal Behavior, pp 97–105. New York: New York Academy of Science Annals, 1986.Google Scholar
  8. 8.
    Roy, A. Family history of suicide in manic-depressive patients. Journal of Affective Disorders, 8, 187–189, 1985.Google Scholar
  9. 9.
    Tsuang, M. Risk of suicide in the relatives of schizophrenics, manics, depressives, and controls. Journal of Clinical Psychiatry, 44, 396–400, 1983.Google Scholar
  10. 10.
    Roy, A. Segal, N., Centerwall, B. Robinette, D. Suicide in twins. Archives of General Psychiatry, 48, 29–32, 1991.Google Scholar
  11. 11.
    Haberlandt, W. Aportacion a la genetica del suicide. Folia Clinica Int, 17, 319–322, 1967.Google Scholar
  12. 12.
    Haberlandt, W. Der suizid als genetisches problem (zwilling and familien analyse). Anthropologischer Anzeiger, 29, 65–89, 1965.Google Scholar
  13. 13.
    Juel-Nielsen, N. Videbech, T. A twin study of suicide. Acta Geneticae Medicae et Gemellologiae (Roma), 19, 307–310, 1970.Google Scholar
  14. 14.
    Zaw, K. A suicidal family. British Journal of Psychiatry, 189, 68–69, 1981.Google Scholar
  15. 15.
    Egeland, J. Sussex, J. Suicide and family loading for affective disorders. Journal of the American Medical Association, 254, 915–918, 1985.Google Scholar
  16. 16.
    Schulsinger, F., Kety, S., Rosenthal, D. Wender, P. (1979). A family study of suicide. In M. Schou, & E. Stromgren (eds.), Origins, Prevention and Treatment of Affective Disorders, pp. 277–287. New York: Academic Press.Google Scholar
  17. 17.
    Wender, P., Kety, Rosenthal, D., Schulsinger, F., Ortmann, J. Lunde, I. Psychiatric disorders in the biological and adaptive families of adopted individuals with affective disorders. Archives of General Psychiatry, 43, 923–929, 1986.Google Scholar
  18. 18.
    Kety, S. Genetic factors in suicide. In A. Roy (ed.), Suicide, pp. 41–45. Baltimore, MD: Williams & Wilkins, 1986.Google Scholar
  19. 19.
    Asberg, M., Traskman, L. Thoren, P., 5-HIAA in the cerebrospinal fluid: A biochemical suicide predictor? Archives of General Psychiatry, 33, 1193–1197, 1976.Google Scholar
  20. 20.
    van Praag, H. Depression, suicide and the metabolism of serotonin in the brain. Journal of Affective Disorders, 4, 275–290, 1982.Google Scholar
  21. 21.
    Roy, A. Linnoila, M. Suicidal behavior, impulsiveness and serotonin. Acta Psychiatrica Scandinavica, 78, 529–535, 1988.Google Scholar
  22. 22.
    Traskman, L., Asberg, M., Bertilsson, L., Sjostrand, L. Monoamine metabolites in CSF and suicidal behavior. Archives of General Psychiatry, 38, 631–636, 1981.Google Scholar
  23. 23.
    Banki, C., Arato, M., Papp, Z., Kurez, M. Biochemical markers in suicidal patients: investigations with cerebrospinal fluid amine metabolites and neuroendocrine tests. Journal of Affective Disorders, 6, 341–350, 1984.Google Scholar
  24. 24.
    Stanley, M., Mann, J. & Cohen, S. Serotonin and serotonergic receptors in suicide. In Psychobiology of Suicidal Behavior. (pp. 122–127). New York: Annals of New York, 1986. Academy of Sciences.Google Scholar
  25. 25.
    Agren, H. Symptom patterns in unipolar and bipolar depression correlating with monoamine metabolites in the cerebrospinal fluid, II: suicide. Psychiatry Research, 3, 225–236, 1980.Google Scholar
  26. 26.
    Montgomery, S., Montgomery, D. Pharmacological prevention of suicidal behavior. Journal of Affective Disorders, 4, 291–298, 1982.Google Scholar
  27. 27.
    Roy, A. Agren, H., Pickar, D., Linnoila, M., Doran, A., Cutler, N., Paul, S. Reduced CSF concentration of homovanillic acid and homovanillic acid to 5-hydroxyindoleacetic acid ratios in depressed patients: relationship to suicidal behavior and dexamethasone nonsuppression. American Journal of Psychiatry, 143, 1539–1545, 1986.Google Scholar
  28. 28.
    Roy, A., DeJong J. Linnoila, M. Cerebrospinal fluid monoamine metabolites and suicidal behavior in depressed patients. Archives of General Psychiatry, 46, 609–612, 1989.Google Scholar
  29. 29.
    Roy, A. Marked reductions in indexes of dopamine metabolism among patients with depression who attempt suicide: Archives of General Psychiatry. 49, 447–450, 1992.Google Scholar

Copyright information

© Human Sciences Press, Inc 1993

Authors and Affiliations

  • Alec Roy
    • 1
  1. 1.Englewood

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