Psychiatric Quarterly

, Volume 58, Issue 3, pp 213–217 | Cite as

Increase in white blood cell count and serum sodium level following the addition of lithium to carbamazephine treatment among three chronically psychotic male patients with disturbed affective states

  • W. V. R. Vieweg
  • G. R. Yank
  • W. T. Rowe
  • L. S. Hovermale
  • A. H. Clayton
Case Reports


Three male chronically psychotic patients (mean age 33.0±S.D. 7.2 years), two with schizoaffective disorder and one with organic affective disorder, received carbamazepine (CBZ) because of affective symptoms (and, in one case, partial complex seizures) refractory to management with antipsychotic drugs. Coincident with CBZ administration (and clinical improvement), hyponatremia developed thought to be due to the antidiuretic effect of this drug. Lithium was added to counteract the antidiuretic effect of CBZ. Further clinical improvement ensured, serum sodium levels became normal, and there was an increase in the white blood cell count in each patient. The clinical implications of our findings are discussed.


Public Health Lithium Male Patient Carbamazepine Clinical Implication 
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Copyright information

© Human Sciences Press 1986

Authors and Affiliations

  • W. V. R. Vieweg
    • 1
  • G. R. Yank
    • 1
  • W. T. Rowe
    • 1
  • L. S. Hovermale
    • 1
  • A. H. Clayton
    • 1
  1. 1.Clinical Evaluation Service, Western State Hospital, Department of Mental Health and Mental Retardation, Commonwealth of Virginia, and the Departments of Behavioral Medicine and Psychiatry and Internal MedicineUniversity of Virginia School of MedicineCharlottesville

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