The development of fatigue during the transmission of excitation through the frog neuromuscular synapse was studied. The blocking of neuromuscular transmission during fatigue was shown to be based on a reduction in the quantum composition of the mediator. Liberation of the mediator is disturbed not by a decrease in the reserves of acetylcholine in motor nerve endings, but by a decrease in the probability of liberation of each quantum.
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Nikol'skii, E.E., Poletaev, G.I. Investigation of the mechanism of neuromuscular transmission blocking during low-frequency nerve stimulation. Neurophysiology 9, 58–63 (1977). https://doi.org/10.1007/BF01063546
- Nerve Stimulation
- Nerve Ending
- Motor Nerve
- Neuromuscular Transmission