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Investigation of the mechanism of neuromuscular transmission blocking during low-frequency nerve stimulation

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The development of fatigue during the transmission of excitation through the frog neuromuscular synapse was studied. The blocking of neuromuscular transmission during fatigue was shown to be based on a reduction in the quantum composition of the mediator. Liberation of the mediator is disturbed not by a decrease in the reserves of acetylcholine in motor nerve endings, but by a decrease in the probability of liberation of each quantum.

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Additional information

S. V. Kurashov State Medical Institute, Kazan'. Translated from Neirofiziologiya, Vol. 9, No. 1, pp. 78–85, January–February, 1977.

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Nikol'skii, E.E., Poletaev, G.I. Investigation of the mechanism of neuromuscular transmission blocking during low-frequency nerve stimulation. Neurophysiology 9, 58–63 (1977). https://doi.org/10.1007/BF01063546

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  • Acetylcholine
  • Nerve Stimulation
  • Nerve Ending
  • Motor Nerve
  • Neuromuscular Transmission