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Nonadrenergic inhibitory postsynaptic potentials of gastric smooth muscle cells

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Abstract

Single intramural stimulation of the atropinized muscle strip of the guinea pig stomach by square pulses was accompanied by the formation of inhibitory postsynaptic potentials (IPSPs) in the muscle cells and by relaxation of the strip. The mean latent period of the IPSPs was 150±15 msec, and the time for its amplitude to rise and fall was 150±15 and 375±92 msec respectively. The latent period of the onset of relaxation of the muscle strip was 1850±230 msec. The amplitude and rate of rise of these IPSPs increased with an increase in the strength of stimulation. This shows that the same gastric muscle cell is under the inhibitory influence not of one, but of several nerve fibers. The effectiveness of synaptic transmission was largely dependent on the character of the preceeding stimulation. For instance, in response to repeated stimulation with short intervals facilitation was observed, but after repetitive stimulation had ended posttetanic depression followed.

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Literature cited

  1. 1.

    K. K. Boev, M. F. Shuba, and V. M. Taranenko, "Electrophysiological properties of the smooth muscles of the cat stomach," in: Mechanics of Neurohumoral Regulation of Autonomic Functions [in Russian], Nauka, Leningrad (1970).

  2. 2.

    D. S. Vorontsov and M. F. Shuba, Physical Electrotonus of Nerves and Muscles [in Russian], Naukova Dumka, Kiev (1966).

  3. 3.

    I. A. Vladimirova and M. F. Shuba, "Inhibitory synaptic potentials of smooth-muscle cells of the taenia coli of the guinea pig," Neirofiziologiya,2, 541 (1970).

  4. 4.

    R. S. Orlov, The Physiology of Smooth Muscle [in Russian], Meditsina, Moscow (1967).

  5. 5.

    M. F. Shuba, "Physical electrotonus of smooth muscle," Biofizika,6, 521 (1961).

  6. 6.

    T. Bennett, "Nerve-mediated excitation and inhibition of the smooth muscle cells of the avian gizzard," J. Physiol. (London),204, 669 (1969).

  7. 7.

    M. R. Bennett, G. Burnstock, and M. E. Holmann, "Transmission from perivascular inhibitory nerves to the smooth muscle cells of the guinea-pig taenia coli," J. Physiol. (London),182, 527 (1966).

  8. 8.

    M. R. Bennett, G. Burnstock, and M. E. Holmann, "Transmission from intramural inhibitory nerves to the smooth muscle cells of the guinea-pig taenia coli," J. Physiol. (London),182, 541 (1966).

  9. 9.

    E. Bulbring and T. Tomita, "Properties of the inhibitory potential of smooth muscle as observed in response to field stimulation of the guinea-pig taenia coli," J. Physiol. (London),189, 299 (1967).

  10. 10.

    E. Bulbring and M. D. Gershon, "5-Hydroxytryptamine participation in the vagal inhibitory innervation of the stomach," J. Physiol. (London),192, 823 (1967).

  11. 11.

    G. Burnstock, G. Campbell, M. Bennett, and M. Holmann, "Inhibition of the smooth muscle of the taenia coli," Nature,200, 581 (1963).

  12. 12.

    G. Burnstock, G. Campbell, and M. Rand, "The inhibitory innervation of the guinea-pig caecum," J. Physiol. (London),182, 504 (1966).

  13. 13.

    G. Campbell, "The inhibitory nerve fibers in the vagal supply to the guinea-pig stomach," J. Physiol. (London),185, 600 (1966).

  14. 14.

    M. D. Gershon, "Inhibition of gastrointestinal movement by sympathetic nerve stimulation. The site of action," J. Physiol. (London),189, 317 (1967).

  15. 15.

    J. S. Gillespie, "Spontaneous mechanical and electrical activity of stretched and unstretched intestinal smooth muscle cells and their response to sympathetic nerve stimulation," J. Physiol. (London),162, 54 (1962).

  16. 16.

    B. A. McSwiney and J. M. Robson, "The response of smooth muscle to stimulation of the vagus nerve," J. Physiol. (London),68, 124 (1929).

  17. 17.

    J. Martinson, "The effect of graded stimulation of efferent vagal nerve fiber on gastric mobility," Acta Physiol. Scand.,62, 256 (1964).

  18. 18.

    J. Martinson, "Vagal relaxation of the stomach. Experimental reinvestigation of the concept of the transmission mechanism," Acta Physiol. Scand.,64, 453 (1965).

  19. 19.

    J. Martinson, "Studies of the efferent vagal control of the stomach," Acta Physiol. Scand.,65, Suppl. 255, 1 (1965).

  20. 20.

    J. Martinson and A. Murez, "Excitatory and inhibitory effects of vagus stimulation on gastric mobility in the cat," Acta Physiol. Scand.,57, 309 (1963).

  21. 21.

    T. Osa and H. Kuriyama, "The membrane properties and decremental conduction in the fundus of the guinea-pig stomach," Jap. J. Physiol.20, 626 (1970).

  22. 22.

    W. D. M. Paton and J. R. Vane, "An analysis of the responses of the isolated stomach to electrical stimulation and drugs,’ J. Physiol. (London),165, 10 (1963).

  23. 23.

    Y. Sacomoto and H. Kuriyama, "The relationship between the electrical and mechanical activity of the guinea-pig stomach," Jap. J. Physiol.,20, 640 (1970).

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Additional information

A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vol. 4, No. 2, pp. 216–222, March–April, 1972.

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Atanasova, E.S., Vladimirova, I.A. & Shuba, M.F. Nonadrenergic inhibitory postsynaptic potentials of gastric smooth muscle cells. Neurophysiology 4, 165–169 (1972). https://doi.org/10.1007/BF01063423

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Keywords

  • Muscle Cell
  • Smooth Muscle Cell
  • Nerve Fiber
  • Latent Period
  • Short Interval