Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Habituation of postsynaptic unit responses of the cat motor cortex to stimuli of different modalities

  • 17 Accesses

Abstract

Habituation (extinction) of postsynaptic unit responses of the cat motor cortex to repetitive electrodermal, photic, acoustic, and combined bimodal stimulation was investigated by intracellular recording. Habituation was shown by a decrease in the number of spikes per grouped discharge and a decrease in the amplitude and duration of the EPSPs, and sometimes IPSPs, on repetition of the stimulus. The way in which the course of habituation depends on the modality and duration of stimulation (at a constant frequency of 1/sec) is examined. Habituation of postsynaptic responses to sensory stimuli is observed with neurons of different functional groups, namely identified neurons of pyramidal tract and unidentified neurons, some of which were evidently pyramidal neurons and interneurons. The hypothesis is put forward that the habituation of PSPs of the cortical neurons is based on processes taking place mainly at the subcortical level.

This is a preview of subscription content, log in to check access.

Literature cited

  1. 1.

    A. S. Batuev, “Associative evoked responses of the frontal cortex”, Neirofiziologiya,2, 373 (1970).

  2. 2.

    N. N. Vasilevskii, Neuronal Mechanisms of the Cerebral Cortex [in Russian], Meditsina, Leningrad (1968).

  3. 3.

    O. S. Vinogradova, “Investigation of habituation of single neurons in various brain structures and, in particular, in the hippocampus”, Proceedings of the 5th Symposium of the 18th International Congress on Psychology [in Russian], Nauka, Moscow (1966), pp. 55–58.

  4. 4.

    O. S. Vinogradova and J. F. Lindsley, “Extinction of responses to sensory stimuli in the single neuron of the visual cortex of the unanesthetized rabbit”, Zh. Vyssh. Nervn. Deyat.,13, 207 (1963).

  5. 5.

    L. L. Voronin and L. I. Tanengol'ts, “Postsynaptic responses of neurons of the cat motor cortex to stimuli of different modalities”, Zh. Vyssh. Nervn. Deyat.,19, 71 (1969).

  6. 6.

    D. N. Lenkov, Supraspinal Synaptic Effects on Lumbar Motoneurons in Kittens, Author's Abstract of Dissertation, Leningrad (1969).

  7. 7.

    A. A. Pigorov, “Investigation of the habituation response of neurons of the cat motor cortex”, Neirofiziologiya, No. 3, 245 (1971).

  8. 8.

    E. N. Sokolov, “Neuronal mechanisms of habituation as the simplest form of the conditioned reflex”, Zh. Vyssh. Nervn. Deyat.,15, 249 (1969).

  9. 9.

    G. Horn, “Neuronal mechanism of the response to novelty”, in: Neuronal Mechanisms of the Orienting Reflex [in Russian], Moscow University Press (1970), pp. 25–46.

  10. 10.

    J. C. Eccles, Inhibitory Pathways of the Central Nervous System [Russian translation], Mir, Moscow (1971).

  11. 11.

    S. A. Anderson, “Intracellular postsynaptic potentials in the somatosensory cortex of the cat”, Nature,205, 297 (1965).

  12. 12.

    T. Araki and T. Otani, “Response of single motoneurones to direct stimulation in toad's spinal cord”, J. Neurophysiol.,18, 472 (1955).

  13. 13.

    J. Bruner and D. Kennedy, “Habituation: occurrence at a neuromuscular junction”, Science,169, 92 (1970).

  14. 14.

    G. Horn, “Neuronal mechanisms of habituation”, Nature,215, 707 (1967).

  15. 15.

    E. R. Kandel, “Nerve cells and behavior”, Sci. Amer.,223, 57 (1970).

  16. 16.

    E. R. Kandel, “Cellular analysis of habituation and dishabituation of a defensive withdrawal reflex in Aplysia”, Proceedings of the 25th International Congress of Physiological Science, Vol. 8, Munich (1971), pp. 203–204.

  17. 17.

    O. Oscarsson, I. Rosen, and I. Sulg, “Organization of neurons in the cat cerebral cortex that are influenced from group I muscle afferents”, J. Physiol. (London),183, 189 (1966).

  18. 18.

    M. Otsuka, M. Endo, and Y. Nonomura, “Presynaptic nature of neuromuscular depression”, Jap. J. Physiol.,12, 573 (1962).

  19. 19.

    S. Sharpless and H. H. Jasper, “Habituation of the arousal reaction”, Brain,79, 655 (1956).

  20. 20.

    C. S. Sherrington, “Reciprocal innervation of antagonistic muscles. 13th note. On the antagonism between reflex inhibition and reflex excitation”, Proc. Roy. Soc. B.,80, 565 (1908).

  21. 21.

    W. A. Spencer, R. F. Thompson, and D. R. Neilson, Jr., “Response decrement of the flexion reflex in the acute spinal cat and transient restoration by strong stimuli”, J. Neurophysiol.,29, 240 (1966).

  22. 22.

    C. Stefanis and H. H. Jasper, “Intracellular microelectrode studies of antidromic responses in cortical pyramidal tract neurones”, J. Neurophysiol.27, 828 (1964).

  23. 23.

    K. Tasaki, J. Tsukahara, S. Ito, M. J. Wayner, and W. J. Ju, “A simple, direct and rapid method for filling microelectrodes”, Physiol. Behav.,3, 1009 (1968).

  24. 24.

    L. Tauc, “Synaptic mechanisms in long-term changes in neuronal activity”, Proceedings of the 25th International Congress of Physiological Science, Vol. 8, Munich (1971), pp. 201–202.

  25. 25.

    R. F. Thompson and W. A. Spencer, “Habituation; a model phenomenon for the study of neuronal substrates of behavior”, Physiol. Rev.,73, 16 (1966).

  26. 26.

    B. G. Wickelgran, “Habituation of spinal motoneurones”, J. Neurophysiol.,30, 1404 (1967).

  27. 27.

    B. G. Wickelgran, “Habituation of spinal interneurones”, J. Neurophysiol.,30, 1424 (1967).

Download references

Additional information

A. A. Zhdanov Leningrad State University. Translated from Neirofiziologiya, Vol. 4, No. 5, pp. 545–553, September–October, 1972.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Pirogov, A.A., Lenkov, D.N. Habituation of postsynaptic unit responses of the cat motor cortex to stimuli of different modalities. Neurophysiology 4, 421–427 (1972). https://doi.org/10.1007/BF01063015

Download citation

Keywords

  • Motor Cortex
  • Cortical Neuron
  • Pyramidal Neuron
  • Pyramidal Tract
  • Sensory Stimulus