The effect of the central analgesic fentanyl on evoked potentials and responses of single Purkinje cells in the cerebellar cortex to stimulation of the sensomotor cortex and of somatic nerves was investigated in unanesthetized cats. Injection of fentanyl in an analgesic dose (10–30 µg/kg, intravenously) had no appreciable effect on evoked potentials and led only to very slight changes in spontaneous activity and responses of Purkinje cells. As a rule fentanyl, in a dose of 30 µg/kg, depressed, but in a dose of 10 µg/kg, facilitated responses and spontaneous activity of Purkinje cells. This effect of fentanyl is negligible compared with the action of barbiturate anesthetics on responses of cerebellar cortical neurons. Consequently, fentanyl can be used for analgesia during electrophysiological investigations of the cerebellar cortex in unanesthetized cats.
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Arshavskii, Y.I., Berkinblit, M.B., Popova, L.B. et al. Possible use of an analgesic (fentanyl) during electrophysiological investigations of the cerebellar cortex. Neurophysiology 11, 438–444 (1979). https://doi.org/10.1007/BF01062840
- Purkinje Cell
- Cortical Neuron
- Spontaneous Activity