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Pharmacokinetics of phenylethylacetylurea (pheneturide), an old antiepileptic drug

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Abstract

The pharmacokinetics of pheneturide (a decarboxylation product of phenobarbital), used to prevent psychomotor seizures for many years, was studied in normal human volunteers. To measure the drug in plasma and urine, a highly sensitive and reproducible thin-layer chromatography-reflectance spectrophotometric assay was developed. The results show that pheneturide follows first-order kinetics in the dose range studied. Its half-life after single doses is 54 hr (range 31–90), and its total body clearance (100% nonrenal) is 2.6 liters/hr (range 1.73–3.59). After repetitive administration, half-life is 40 hr (but clearance remains unchanged because of a lower volume of distribution). Because of the long half-life, repetitive administration results in a continuous steady-state level and makes this drug (kinetically) ideal for long-term use.

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References

  1. 1.

    M. J. Orloff, P. E. Feldmann, C. H. Shaiova, and C. C. Pfeiffer. Anticonvulsant and toxic effects of alpha-phenyl-butyryl urea. Neurology1:377–385 (1951).

  2. 2.

    J. A. Wright. Trinuride in the treatment of major epilepsy.Epilepsia 6:67–74 (1965).

  3. 3.

    C. J. Vas and M. J. Parsonage. Treatment of intractable temporal lobe epilepsy with pheneturide.Acta Neurol. Scand.43:580–586 (1967).

  4. 4.

    R. Schweingruber and E. Ketz. The contribution of the acetylureas to the treatment of epilepsy.Schweiz. Med. Wochenschr. 90:423–426 (1960).

  5. 5.

    E. Ketz, C. Bernoulli, and Ph. Gold-Aubert. Erfahrungen mit Pheneturid bei therapierefraktären Epilepsien.Schweiz. Rundschau. Med. (Praxis) 61:1146–1152 (1972).

  6. 6.

    R. L. Galeazzi, N. Wad, and M. Egli. Pheneturide: A highly effective antiepileptic drug characterized by simple and predictable kinetics.Clin. Res. 25:270 (1977).

  7. 7.

    L. R. Treiber. Standardization of the direct spectrophotometric quantitative analysis of chromatograms. IV. A comparative study on the most common mathematical treatments of thin-layer densitometric problems.J. Chromatogr. 100:123–135 (1974).

  8. 8.

    H. G. Boxenbaum, S. Riegelman, and R. M. Elashoff. Statistical estimations in pharmacokinetics.J. Phamacokin. Biopharm. 2:123–148 (1974).

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Author information

Correspondence to Renato L. Galeazzi.

Additional information

Part of this study has been reported in abstract (Clin. Res. 25:270, 1977).

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Galeazzi, R.L., Egli, M. & Wad, N. Pharmacokinetics of phenylethylacetylurea (pheneturide), an old antiepileptic drug. Journal of Pharmacokinetics and Biopharmaceutics 7, 453–462 (1979). https://doi.org/10.1007/BF01062387

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Key words

  • pheneturide
  • antiepileptics
  • pharmacokinetics
  • TLC-UV densitometry