Journal of Neuro-Oncology

, Volume 23, Issue 3, pp 175–183

The RG2 rat glioma model

  • Alf Tore Aas
  • Arne Brun
  • Catharina Blennow
  • Susanne Strömblad
  • Leif G. Salford
Laboratory Investigation

DOI: 10.1007/BF01059948

Cite this article as:
Aas, A.T., Brun, A., Blennow, C. et al. J Neuro-Oncol (1995) 23: 175. doi:10.1007/BF01059948

Summary

The ethylnitrosourea-induced cell line RG2 grows very well in infinite cell culturein vitro, and provides a simple, reproducible glioma model when inoculated into the brains of syngeneic Fischer 344 rats. We have used this tumor model in a series of therapy studies. We here report our experiences of the untreated (= tumor bearing control) animals, e.g. in terms of the techniques employed and also the growth, histology and effects upon the blood-brain barrier of the tumors. Weight loss as a measure of systemic effects during tumor development is also described. The RG2 model has considerable potential as a suitable tool for experimental neuro-oncology.

Key words

blood-brain barrier brain neoplasm experimental rat 

Copyright information

© Kluwer Academic Publishers 1995

Authors and Affiliations

  • Alf Tore Aas
    • 1
  • Arne Brun
    • 2
  • Catharina Blennow
    • 1
  • Susanne Strömblad
    • 1
  • Leif G. Salford
    • 1
  1. 1.Division of Experimental Neurooncology, Department of NeurosurgeryUniversity HospitalLundSweden
  2. 2.Division of Neuropathology, Department of PathologyUniversity HospitalLundSweden

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