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Responses of rabbit visual cortical neurons to intracortical electrical stimulation

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Abstract

Responses of rabbit visual cortical neurons to single and repetitive intracortical electrical stimulation were investigated. The stimulating electrode was located 0.7–1.2 mm away from the recording electrode. Response thresholds to single stimulation were as a rule 150–180 µA, whereas to series of stimuli they were 30–60 µA. The latent period to the first spike averaged 5–15 msec but the probability of the initial discharge was very low, namely 3–6%. With an increase in current intensity the duration of the initial inhibitory pause was increased in half of the neurons responding to it, whereas in the rest it was unchanged. After presentation of series of stimuli spontaneous activity was enhanced for a short time (4–6 sec). In about half of the cells the same kinds of discharge dynamics were observed in response to repetitive stimulation (frequency 0.25 Hz) as in responses to light, but more neurons with sensitization of discharge and fewer "habituating" neurons took part in responses to electrical stimulation. It is postulated that stimulation of a given point of the visual cortex evokes excitation of a local neuron hypercolumn and inhibition of neighboring cell columns.

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Additional information

M. V. Lomonosov Moscow State University. Translated from Neirofiziologiya, Vol. 15, No. 4, pp. 412–419, July–August, 1983.

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Polyanskii, V.B., Latanov, A.V. & Ruderman, G.L. Responses of rabbit visual cortical neurons to intracortical electrical stimulation. Neurophysiology 15, 307–313 (1983). https://doi.org/10.1007/BF01059872

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Keywords

  • Electrical Stimulation
  • Latent Period
  • Visual Cortex
  • Cortical Neuron
  • Neighboring Cell